Pharmacogenetics: Single Gene Effects

  • Bert N. La Du


Dr. Vesell and I have been asked to review some principles of pharmacogenetics that relate to the pharmacokinetic theme of this conference. We have divided the topic: Dr. Vesell will discuss multiple gene effects and their implications, and I will mention some single gene effects which can modify drug metabolism and drug response in man. We both are studying the way genetic factors account for rather remarkable person-to-person differences in drug responses and pharmacodynamics, and we hope that pharmacokinetic models will be designed that will take into account these genetically determined individual differences.


Adverse Drug Reaction Acid Phosphatase Heterozygous Carrier Slow Acetylators Choline Ester 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Bert N. La Du
    • 1
  1. 1.The Stella and Charles Guttman Laboratories for Human Pharmacology and Pharmacogenetics Department of PharmacologyNew York University Medical SchoolNew YorkUSA

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