Target Organ Modification in Pharmacology: Reversible Osmotic Opening of the Blood-Brain Barrier by Opening of Tight Junctions

  • Stanley I. Rapoport


We often consider how to modify the physical-chemical properties of a drug—its distribution, excretion, and metabolism—so as to increase its effective action at the target organ. In this paper I shall discuss how a target organ itself—the brain and blood-brain barrier system—can be modified to facilitate entry of normally excluded drugs. I shall present physiological and morphological evidence that the blood-brain barrier can be opened osmotically in a reversible manner without producing gross neurological damage to the animal.


Tight Junction Evans Blue Lipid Solubility Carbamate Ethyl Lingual Artery 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Stanley I. Rapoport
    • 1
  1. 1.Laboratory of NeurophysiologyNational Institute of Mental HealthBethesdaUSA

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