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Pharmacokinetics and Pharmacodynamics of Acetazolamide in Relation to its Use in the Treatment of Glaucoma

  • Per J. Wistrand

Abstract

Many speakers have alluded to the problem of describing the kinetics of the events at the drug receptor in relation to the time course of the physiological response. I would like to give an example of a drug action where it might be possible to unify the pharmacokinetic and the pharmacodynamic events.

Keywords

Enzyme Inhibition Carbonic Anhydrase Aqueous Humour Pharmacodynamic Event Carbonic Anhydrase Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Lehman, B., Linnér, E., and Wistrand, P. J., 1969, The pharmacokinetics of acetazolamide in relation to its use in the treatment of glaucoma and to its effects as an inhibitor of carbonic anhydrases, in: Advances in the Biosciences Vol. 5, pp. 197–217 (G. Raspé, ed.), Pergamon Press, Oxford.Google Scholar
  2. Maren, T. H., 1967, Carbonic anhydrase: chemistry, physiology and inhibition, Physiol. Rev. 47: 595–781.PubMedGoogle Scholar
  3. Bárány, E., 1947, The rate of equilibration of intraocular pressure: On the boundary between transient and stationary intraocular pressure changes, Acta Ophthal. 25: 175–193.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Per J. Wistrand
    • 1
  1. 1.Department of Medical PharmacologyUniversity of UppsalaUppsalaSweden

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