Pharmacokinetics and Pharmacodynamics of Acetazolamide in Relation to its Use in the Treatment of Glaucoma

  • Per J. Wistrand


Many speakers have alluded to the problem of describing the kinetics of the events at the drug receptor in relation to the time course of the physiological response. I would like to give an example of a drug action where it might be possible to unify the pharmacokinetic and the pharmacodynamic events.


Enzyme Inhibition Carbonic Anhydrase Aqueous Humour Pharmacodynamic Event Carbonic Anhydrase Inhibitor 
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  1. Lehman, B., Linnér, E., and Wistrand, P. J., 1969, The pharmacokinetics of acetazolamide in relation to its use in the treatment of glaucoma and to its effects as an inhibitor of carbonic anhydrases, in: Advances in the Biosciences Vol. 5, pp. 197–217 (G. Raspé, ed.), Pergamon Press, Oxford.Google Scholar
  2. Maren, T. H., 1967, Carbonic anhydrase: chemistry, physiology and inhibition, Physiol. Rev. 47: 595–781.PubMedGoogle Scholar
  3. Bárány, E., 1947, The rate of equilibration of intraocular pressure: On the boundary between transient and stationary intraocular pressure changes, Acta Ophthal. 25: 175–193.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Per J. Wistrand
    • 1
  1. 1.Department of Medical PharmacologyUniversity of UppsalaUppsalaSweden

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