The ability of the blood leukocytes to produce interferon was first described by Gresser . Human leukocytes were used in these experiments, and after infection with Sendai or measles virus they produced an inhibitor which was shown to be identical with interferon. When the liquid part of a suspension of infected leukocytes from two healthy donors and 18 patients with different diseases, including three patients with congenital agammaglobulinemia, was tested, different concentrations of interferon were found. The quantity of interferon produced was directly proportional to the concentration of leukocytes in the suspension.
KeywordsHuman Leukocyte Newcastle Disease Virus Vesicular Stomatitis Virus Peritoneal Exudate Interferon Production
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