Lithium pp 83-106 | Cite as

Pharmacology—Neurophysiology of Lithium

  • Joyce G. Small
  • Iver F. Small


Trace amounts of the cation, lithium, are normally present in the human body. As such, lithium is a very different kind of agent than most other psychoactive substances that are used therapeutically. The matter of how this simple inorganic ion can exert profound effects upon the CNS and somehow dampen the cycles of mental disturbance in patients with manic-depressive disease presents a fascinating area for neurophysiological research. Although considerable work on this subject has already been accomplished, much more remains to be performed.


Contingent Negative Variation Lithium Level Squid Giant Axon Orbital Frontal Cortex Serum Lithium Level 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Joyce G. Small
    • 1
  • Iver F. Small
    • 1
  1. 1.LaRue D. Carter Memorial Hospital, Department of PsychiatryIndiana University Medical CenterIndianapolisUSA

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