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Lithium pp 33-49 | Cite as

Pharmacology—Lithium Absorption, Distribution, Renal Handling, and Effect on Body Electrolytes

  • Leslie Baer

Abstract

Lithium is rapidly absorbed by the gastrointestinal tract. Blood levels peak after single oral doses of lithium between 2 to 4 hours (Amdisen, 1969; Platman et al., 1968; Trautner et al., 1955). Accordingly, in clinical practice blood lithium levels are measured at least 8 hours after the last dose to avoid sampling during these peaks. This very rapid absorption has led to the introduction of slow-release forms of lithium to achieve more constant blood levels (Amdisen, 1969; Coppen and Bailey, 1970). It is possible that by avoiding extreme flings of blood lithium levels and by permitting more precise monitoring of serum lithium concentration, the incidence of lithium-induced side effects will eventually be reduced.

Keywords

Plasma Renin Activity Lithium Treatment Nephrogenic Diabetes Insipidus Renal Handling Serum Lithium Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Leslie Baer
    • 1
  1. 1.Departments of Medicine and PsychiatryColumbia University College of Physicians and Surgeons and the New York State Psychiatric InstituteNew YorkUSA

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