Lithium pp 201-236 | Cite as

The Affective Disorders: Clinical and Epidemiological Aspects

  • Gerald L. Klerman
  • James E. Barrett


In the history of science, new technologies have had profound impact on theory and research methods. This is especially true in medicine where new treatments often have far-ranging effects on theoretical concepts as well as important consequences for the diagnosis and treatment of patients. Within psychiatry such changes are currently occurring in the treatment of the affective disorders. Demonstration of the therapeutic efficacy of psychotropic drugs, and in particular of lithium, has focused greater attention on the diagnosis, the symptomatology, and the clinical course of manic and depressive patients. New concepts and theories are emerging and older theories are being revised (Klerman, 1971).


Affective Disorder Manic Episode Depressive Illness Epidemiological Aspect Incidence Figure 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Gerald L. Klerman
    • 1
  • James E. Barrett
    • 1
  1. 1.Harvard Medical SchoolErich Lindemann Mental Health CenterBostonUSA

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