Abstract
Since lithium produces a dramatic antimanic response and a response which seems to some degree specific to a relatively narrow range of mental disorders as opposed to more nonspecific type tranquilizing agents (Cade, 1949), this degree of specificity may provide a tool for understanding the cause of mania.
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References
Amdisen, A., and Schou, M., 1967, Biochemistry of depression. Lancet 1:507.
Aronoff, M., Evens, R., and Durell, J., 1971, Effect of lithium salts on electrolyte metabolism, J. Psychiat. Res. 8:139.
Baer, L., Durell, J., Bunney, W. E., Jr., Levy, B. S., and Cardon, P., 1969a, Sodium22 retention and 17-hydroxycorticosteroid excretion in affective disorders, J. Psychiat. Res. 6:289.
Baer, L., Platman, S. R., and Fieve, R. R., 1969b, Aldosterone-dependent component of lithium metabolism and the effect of lithium on fluid and electrolyte balance. Read before the NIMH Workshop on Recent Advances in the Psychobiology of Depressive Illnesses, Williamsburg, Va. (April 1969).
Baer, L., Durrell, J., Bunney, W. E., Jr., 1970a, Sodium balance and distribution in lithium carbonate therapy. Arch. Gen. Psychiat. 22:40.
Baer, L., Platman, S. R., and Fieve, R. R., 1970b, The role of electrolytes in affective disorders. Sodium, potassium, and lithium ions. Arch. Gen. Psychiat. 22:108.
Baer, L., Platman, S. R., Kasser, S., and Fieve, R. R., 1971, Mechanism of renal lithium handling and their relationship of mineralocorticoids, J. Psychiat. 8:91.
Baker, M. A., and Winokur, G., 1966, Cerebrospinal fluid lithium in manic illness, Brit. J. Psychiat. 112:163.
Baldessarini, R., and Stephens, J., 1970, Lithium carbonate for affective disorders, Arch. Gen. Psychiat. 22:72.
Black, D. H., and Milne, M. D., 1952, Experimental potassium depletion in man, Clin. Sci. 11:397.
Bleiweiss, H., 1970, Salt supplements with lithium. Lancet 1:416.
Bunney, W. E., Jr., and Davis, J. M., 1965, Norepinephrine in depressive reactions. A review. Arch. Gen. Psychiat. 13:483.
Bunney, W. E., Jr., Goodwin, F., Davis, J. M., and Fawcett, J., 1968, A behavioral-biochemical study of lithium treatment, Am. J. Psychiat. 125:499.
Cade, J. F. J., 1949, Lithium salts in the treatment of psychotic excitement, Med. J. Australia 2:349.
Cade, J. F. J., 1970, Lithium, Sci. Proc. Am. Psychiat. Assoc. 123:155.
Caldwell, H., Westlake, W. J., Connor, S., and Flanagan, T., 1971, A pharmacokinetic analysis of lithium carbonate absorption from several formulations in man, J. Clin. Pharmacol. 11:349.
Carroll, B. J., and Sharp, P. T., 1971, Rubidium and lithium: opposite effects on amine- mediated excitement, Science 172:1355.
Colburn, R., Goodwin, F., Bunney, W. E., Jr., and Davis, J. M., 1967, Effect of lithium on the uptake of noradrenaline by synaptosomes. Nature 215:1395.
Coppen, A., and Shaw, D. M., 1967, The distribution of electrolytes and water in patients after taking lithium carbonate, Lancet 2:805.
Coppen, A., Malleson, A., and Shaw, D. M., 1965, Effects of lithium carbonate on electrolyte distribution in man. Lancet 1:682.
Coppen, A., Shaw, D. M., Malleson, A., and Costain, R., 1966, Mineral metabolism in mania, Brit. Med. J. 1:11.
Corrodi, H., Fuxe, L., Hokfelt, T., and Schou, M., 1967, The effect of lithium on cerebral monoamine neurons, Psychopharmacologia 11:345.
Corrodi, H., Fuxe, K., and Schou, M., 1969, The effect of prolonged lithium administration on cerebral monoamine neurons in the rat, Life Sci. 8:643.
Cox, C., Harrison-Read, P. E., Steinberg, H., and Tomkiewicz, M., 1971, Lithium attenuates drug-induced hyperactivity in rats. Nature 232:336.
Crammer, J. L., 1962, Electrolytes and mental state, in: Aspects of Psychiatric Research (D. Richter, ed.), Oxford University Press, New York.
Crammer, J. L., 1970, Renal effects of lithium and calcium and the control of mania. Collegium Internationale Neuropsychopharmacologicum 7:93.
Davenport, V. D., 1950, Distribution of parenterally administered lithium in plasma, brain, and muscle of rats, Am. J. Physiol 163:633.
DeFeudis, F. V., and Delgado, J., 1970, Effect of lithium on amino acid in mouse brain in vivo, Nature 225:749.
Delgado, J. M., 1969, Effects of lithium injections into the amygdala and hippocampus of awake monkeys, Exptl. Neurol. 25:255.
Demers, R., and Heninger, G., 1970, Prelibial edema and sodium retention during lithium carbonate treatment, J. Am. Med. Assoc. 214:1845.
Demers, R., and Heninger, G., 1971, Sodium intake and lithium treatment in mania. Am. J. Psychiat. 128:132.
D’Encarnacao, P. S., and Anderson, K., 1970, Effect of lithium pretreatment on amphetamine and DMI tetrabenazine-produced psychomotor behavior. Diseases Nervous System 31:494.
DeVanzo, J. P., 1968, Pharmacological and biological comparison of lithium and reference antidepressants. Pharmacologist 10:168.
Dostal, T., and Zvolsky, P., 1971, Antiaggressive treatment of lithium in oligophrenic adolescents. Am. Coll. Neuropsychopharmacol. Abst. 1:121.
Doüsa, T., and Hechter, O., 1970, Lithium and brain adenyl cyclase. Lancet 1:834.
Epstein, R., Grant, L., Herjanic, M., and Winokur, G., 1965, Urinary excretion of lithium in mania, J. Am. Med. Assoc. 192:409.
Fann, W. E., Davis, J. M., Janowsky, D. S., Cavanaugh, J. H., Kaufmann, J. S., Griffith, J. D., and Oates, J. A., 1972, The effects of lithium on adrenergic function in man, Clin. Pharm. Therap. 13:71.
Foulks, J., Mudge, G., and Gilman, A., 1952, Renal excretion of cation in the dog during infusion of isotonic solutions of lithium chloride. Am. J. Physiol. 168:642.
Fyro, B., Petterson, V., and Sedvall, G., 1970, Serum lithium levels and side effects during administration of lithium carbonate and two slow release lithium preparations to human: volunteers, Pharmacol Clin. 2:236.
Geisler, A., Schou, M., and Thomsen, K., 1971, Renal lithium elimination in manic-depressive patients—Initial excretion and clearance, Pharmacopsychiatry 10:149.
Gottesfeld, Z., Epstein, B. S., and Samuel, D., 1971, Effects of lithium in concentrations of glutamate and GABA levels in amygdala and hypothalamus. Nature New Biol. 234: 124.
Greenspan, K., 1968, Clinical pharmacology and pending biochemical questions of lithium therapy. Diseases Nervous System 29:178.
Greenspan, K., Goodwin, F., and Bunney, W. E., Jr., 1968a, Lithium ion retention and distribution: patterns during acute mania and normothymia. Arch. Gen. Psychiat. 19:664.
Greenspan, K., Green, R., and Durrell, J., 1968b, Retention and distribution patterns of lithium: A pharmacological tool in studying the pathophysiology of manic-depressive psychosis. Am. J. Psychiat. 125:512.
Greenspan, K., Schildkraut, J., Gordon, E., Levy, B., and Durrell, J., 1969, Catecholamine metabolism in affective disorders. Arch. Gen. Psychiat. 21:710.
Greenspan, K., Aronoff, M. S., and Bogdanski, D. F., 1970, Effect of lithium carbonate on turnover and metabolism of norepinephrine in the rat brain. Pharmacology 3:129.
Harris, C. A., and Jenner, F. A., 1969a, The inhibition of the action of vasopressin by lithium ions, J. Physiol. 200:59.
Harris, C. A., and Jenner, F. A., 1969b, The ionic specificity of lithium as an inhibitor of the action of vasopressin, J. Physiol. 203:73.
Ho, A. K. S., Gershon, S., and Pinckney, L., 1970, The effects of acute and prolonged lithium treatment on the distribution of electrolytes, potassium, and sodium. Arch. Int. Pharmacodyn. 186:54.
Hullin, R. P., McDonald, R., and Dransfield, G. A., 1968a, Metabolic balance studies on the effects of lithium salts in manic-depressive psychosis, in: Proc. IV World Congr. Psychiat. (J. J. Lopezlbor, ed.), pp. 1900–1903, Excerpta Medica Foundation, I. C. S. 150, Amsterdam.
Hullin, R. P., Swinscoe, J., McDonald, R., and Dransfield, G. A., 1968b, Metabolic balance studies on the effect of lithium salts in manic-depressive psychosis, Brit. J. Psychiat. 114: 1561.
Katz, R. L, Chase, T. N., and Kopin, I. J., 1968, Evoked release of norepinephrine and serotonin from brain slices: inhibition by lithium. Science 162:466.
King, L. J., and Carl, J., 1967, Lithium ion effects on brain in vivo, Federation Proc. 26:3104.
King, L. J., Carl, J., and Venson, V., 1969, Effects of lithium on brain energy reserves and cations in vivo, J. Pharmacol. Exptl. Therap. 168:163.
Kiseleva, I. P., and Lapin, I. P., 1969, Antagonistic effect of lithium carbonate on 5-hydroxy-tryptophan-induced head twitches in mice, Pharmacol. Res. Commun. 1:108.
Kiseleva, I. P., Lapin, L P., Oxenkrugal, G. F., and Samsonova, M. L., 1971, Serotonin- ergic component of lithium activity. Collegium Internationale Neuropsychophormo- cologicum Abst. 2:239.
Kopin, L, 1969, How does lithium work? New Engl. J. Med. 280:560.
Krall, A. R., 1967, Potassium and sodium-like effects of lithium on brain mitochondrial phosphorylation. Life Sci. 6:1339.
Krulik, R., 1971, Effect of lithium on aldosterone production by rat adrenals, Arzneimittel-Forsch. 6:889.
Krulik, R., and Zvolsky, P., 1970, The influences of lithium ions on adrenocortical function of rats, Arzneimittel-Forsch. 20:1577.
Kuriyama, K., and Speken, R., 1970, Effect of lithium on content and uptake of norepinephrine and 5-hydroxytryptamine in mouse brain synaptosomes and mitochondria. Life Sci. 9:1213.
Lapin, L, 1969, Lithium and cerebral metabolism. New Engl. J. Med. 281:218.
Lynn, E., 1970, Mania and the use of lithium. Sci. Sum. Am. Psychiat. Assoc. 123:252.
Maggs, R., 1968, Electrolyte changes in lithium therapy (mania), in: Proc. IV World Cong. Psychiat. (J. J. Lopez-Ibor, ed.), pp. 2211–2214, Excerpta Medica Foundation, I C. S. 150, Amsterdam.
Mangoni, A., Andreoli, V., Cabibbe, F., and Mandelli, V., 1970, Body fluid distribution in manic and depressed patients treated with lithium carbonate. Acta Psychiat. Scand. 46:244.
Matussek, N., and Linsmayer, 1968, The effect of lithium and amphetamine of desmethylimipramine-Ro-4–1284-induced motor hyperactivity. Life Sci. 7:371.
Morrison, J. M., Pritchard, H., Braude, M., and D’Aguannot, W., 1971, Plasma and brain lithium levels after lithium carbonate and lithium chloride administration by different routes in rats, Proc. Soc. Exptl. Biol. Med. 137:889.
Murphy, D. L., and Bunney, W. E., Jr., 1971, Total body potassium changes during lithium administration, J. Nervous Mental Disease 152:381.
Murphy, D. L., Colburn, R., Davis, J. M., and Bunney, W. E., Jr., 1969a, Lithium stimulation of monoamine uptake in human platelets. Life Sci. 8:1189.
Murphy, D. L., Goodwin, F. K., and Bunney, W. E., Jr., 1969b, Aldosterone and sodium response to lithium administration in man. Lancet 2:458.
Neilsen, J., 1964, Magnesium-lithium studies 1. Serum and erythrocyte magnesium in patients with manic states during lithium treatment, Acta Psychiat. Scand. 40:190.
Perez-Cruet, J., Tagliamonte, A., Tagliamonte, P., and Gessa, G., 1971, Stimulation of serotonin synthesis by lithium, J. Pharmacol. Exptl. Therap. 178:325.
Perkinson, E., 1969, Pharmacological and biochemical comparison of lithium and reference antidepressants, Proc. Soc. Experimental Biol. Med. 131:685.
Persson, G., 1971, Effects of a sustained-release lithium preparation. Acta Psychiat. Scand. Suppl. 221:33.
Platman, S. R., and Fieve, R., 1968a, Biochemical aspects of lithium in affective disorders. Arch. Gen. Psychiat. 9:659.
Platman, S. R., and Fieve, R., 1968b, Lithium carbonate and plasma Cortisol response in the affective disorders. Arch. Gen. Psychiat. 18:594.
Platman, S. R., and Fieve, R., 1969, Lithium retention and excretion. Arch. Gen. Psychiat. 20:285.
Platman, S. R., Rohrlich, J., and Fieve, R., 1968, absorption and excretion of lithium in manic-depressive disease, Diseases Nervous System 29:733.
Platman, S. R., Fieve, R., and Pierson, R. N., 1970, Effect of mood and lithium carbonate on total body potassium. Arch. Gen. Psychiat. 22:297.
Prien, R. F., Caifey, Z. M., and Klett, J., 1971, The relationship between serum lithium levels and clinical response in acute manics treated With lithium carbonate. Cooperative Studies in Psychiatry, Report No. 91, VA-NIMH Collaborative Study Group, Perry Point, Maryland.
Radomski, J. L., Fuyat, H. N., and Nelson, A. A., 1950, The toxic effects, excretion and distribution of lithium chloride, J. Pharmacol. Exptl. Therap. 100:429.
Sachar, E., 1970, Effect of lithium carbonate therapy on adrenocortical activity. Arch. Gen. Psychiat. 22:304.
Saran, B. M., 1970, Biochemical and clinical effects of lithium carbonate in manic-depressive psychoses. Collegium Internationale Neuropsychopharmacologicum Abst. 7:383.
Schanberg, S. M., Schildkraut, J.J., and Kopin, L. J., 1967, The effects of psychoactive drugs on norepinephrine metabolism in the brain, Biochem. Pharmacol. 16:393.
Schildkraut, J. J., 1965, The catecholamine hypothesis of affective disorders: A review of supporting evidence, Am. J. Psychiat. 122:509.
Schildkraut, J. J., Schanberg, S. M., and Kopin, I. J., 1966, The effects of lithium ion on H-norepinephrine metabolism in brain. Life Sci. 5:1479.
Schildkraut, J. J., Davis, J., and Klerman, G., 1968, Biochemistry of depressions, in: Psychopharmacology, A Review of Progress (D. Efron, J. Cole, J. Levine, and J. R. Wittenborn, eds.), pp. 625–648, Public Health Service Publ. 1836, U.S. Government Printing Office, Washington, D. C.
Schildkraut, J. J., Logue, M. A., and Dodge, G. A., 1969a, The effects of lithium salts on the turnover and metabolism of norepinephrine in rat brain, Psychopharmacologia 14:135.
Schildkraut, J. J., Schanberg, S., Breese, S., and Kopin, I., 1969b, Effect of psychoactive drugs on the metabolism of intracisternally administered serotonin in rat brain, Biochem. Pharm. 18:1971.
Schou, M., 1957, Biology and pharmacology of the lithium ion, Pharmacol. Rev. 1:17.
Schou, M., 1958a, Lithium studies. 1. Toxicity, Acta Pharmacol. Toxicol. 15:70.
Schou, M., 1958b, Lithium studies. 2. Renal elimination. Acta Pharmacol. Toxicol. 15:85.
Schou, M., 1958c, Lithium studies. 3. Distribution between serum and tissues. Acta Pharmacol. Toxicol. 15:115.
Schou, M., 1966, The metabolism and biochemistry of lithium, in: International Symposium on Antidepressant Drugs (S. Garattini and M. N. G. Dukes, eds), pp. 80–83. Excerpta Medica Foundation, Amsterdam.
Schou, M., 1969a, Lithium: elimination rate, dosage, control, poisoning, goiter mode of action. Acta Psychiat. Scand. Suppl. 207:49.
Schou, M., 1969b, Lithium: relation between clinical effects of the drug and its absorption, distribution and excretion, in: The Present Status of Psychotropic Drugs (A. Cerletti and F. S. Bove, eds.), pp. 120–122, Excerpta Medica Foundation, Amsterdam.
Sedvall, G., 1969, Discussion, Acta Psychiat. Scand. Suppl. 207:57.
Sedvall, B., Petterson, V., and Fyro, B., 1970, Individual differences in serum levels of lithium in human subjects receiving fixed doses of lithium carbonate. Relation of renal lithium clearance and body weight, Pharmacol. Clin. 2:231.
Serry, M., 1969a, Lithium retention and response. Lancet 1:1267.
Serry, M., 1969b, The lithium excretion test, Australian-New Zealand J. Psychiat. 3:390.
Shaw, D. M., 1966, Mineral metabolism, mania, and melancholia, Brit. Med. J. 2:262.
Shaw, D. M., and Coppen, A., 1966, Potassium and water distribution in depression, Brit. J. Psychiat. 112:269.
Sheard, M.H., 1970a, Behavioral effects of p-chlorophenylalanine in rats: inhibition by lithium, Commun. Behav. Biol. 5:71.
Sheard, M.H., 1970b, Effect of lithium in foot shock aggression in rats. Nature 228:284.
Sheard, M.H., 1971, Effect of lithium on human aggression, Nature 230:113.
Sheard, M. H., and Aghajanian, G. K., 1970, Activated metabolism of brain serotonin, Life Sci 9:285.
Sletten, J. W., and Gershon, S., 1966, The effects of chlorpromazine on water and electrolyte balance, J. Nervous Mental Disease 142:25.
Sletten, J. W., Pichardo, J., Korol, B., and Gershon, S., 1966, The effect of chlorpromazine on lithium excretion in psychiatric subjects. Current Therap. Res. 8:441.
Solomon, S., 1967, Action of alkali metals on papillary cortical sodium gradient of dog kidney, Proc. Soc. Exptl. Biol Med. 125:1183.
Stancer, N. C., and Kivi, R., 1971, Lithium carbonate and edema. Lancet 2:985.
Stern, D. M., Fieve, P. R., Neff, N. H., and Costa, E., 1969, The effects of lithium chloride administration on brain and heart norepinephrine turnover rates, Psychopharmacologia 14:315.
Stokes, J. W., Mendels, J., and Secunda, S. K., 1970, Predicting clinical response to lithium, Sci. Proc. Am. Psychiat. Assoc. 123:157.
Stokes, J. W., Mendels, J., Secunda, S. K., and Dyson, W. L., 1972, Lithium excretion and therapeutic response, J. Nervous Mental Disease 154:43.
Tagliamonte, A., Tagliamonte, P., Perez-Cruet, J., and Gessa, G., 1971, Increase of brain tryptophan caused by drugs which stimulate serotonin synthesis. Nature New Biol. 229: 125.
Talso, P. J., and Clarke, R. W., 1951, Excretion and distribution of lithium in the dog. Am. J. Physiol. 166:202.
Thomsen, K., 1969, Renal lithium elimination in man and active treatment of lithium poisoning. Acta Psychiat. Scand. Suppl. 207:83.
Thomsen, K., and Schou, M., 1968, Renal lithium excretion in man. Am. J. Physiol. 215: 823.
Thomsen, K., Schou, M., Steiness, L, and Hansen, H.E., 1969, Lithium as an indicator of proximal sodium reabsorption. Pfluegers Arch. Ges. Physiol. 308:180.
Trautner, E. M., Morris, R., Noack, C. H., and Gershon, S., 1955, The excretion and retention of ingested lithium and its effect on the ionic balance of man, Med. J. Australia 2:280.
Tupin, J. P., Schlagenhauf, G. K., and Creson, D. L., 1968, Lithium effects on electrolyte excretion. Am. J. Psychiat. 125:536.
U’Prichard, D. C., and Steinberg, H., 1972, Selective effects of lithium on two forms of spontaneous activity, Brit. J. Pharmacol. 44:349.
Van der Velde, C., and Gordon, M., 1969, Manic-depressive illness, diabetes mellitus, and lithium carbonate. Arch. Gen. Psychiat. 21:478.
Weischer, M. L., 1969, About the antiaggressive effect of lithium, Psychopharmacologia 15:245.
Weischer, M. L., and Opitz, K., 1970, Abschwachung analgetischer Effekte durch Lithium, Arzneimittel-Forsch. 20:1046.
Zvolsky, P. and Grof, P., 1968, Clinical factors determining the serum lithium concentration, Activitas Nervosa Sup. 10:292.
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Davis, J.M., Janowsky, D.S., El-Yousef, K. (1973). Pharmacology—The Biology of Lithium. In: Gershon, S., Shopsin, B. (eds) Lithium. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2022-7_10
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