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Lithium pp 167-188 | Cite as

Pharmacology—The Biology of Lithium

  • John M. Davis
  • David S. Janowsky
  • Khaled El-Yousef

Abstract

Since lithium produces a dramatic antimanic response and a response which seems to some degree specific to a relatively narrow range of mental disorders as opposed to more nonspecific type tranquilizing agents (Cade, 1949), this degree of specificity may provide a tool for understanding the cause of mania.

Keywords

Sodium Intake Lithium Treatment Lithium Chloride Lithium Salt Sodium Retention 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Amdisen, A., and Schou, M., 1967, Biochemistry of depression. Lancet 1:507.Google Scholar
  2. Aronoff, M., Evens, R., and Durell, J., 1971, Effect of lithium salts on electrolyte metabolism, J. Psychiat. Res. 8:139.PubMedGoogle Scholar
  3. Baer, L., Durell, J., Bunney, W. E., Jr., Levy, B. S., and Cardon, P., 1969a, Sodium22 retention and 17-hydroxycorticosteroid excretion in affective disorders, J. Psychiat. Res. 6:289.PubMedGoogle Scholar
  4. Baer, L., Platman, S. R., and Fieve, R. R., 1969b, Aldosterone-dependent component of lithium metabolism and the effect of lithium on fluid and electrolyte balance. Read before the NIMH Workshop on Recent Advances in the Psychobiology of Depressive Illnesses, Williamsburg, Va. (April 1969).Google Scholar
  5. Baer, L., Durrell, J., Bunney, W. E., Jr., 1970a, Sodium balance and distribution in lithium carbonate therapy. Arch. Gen. Psychiat. 22:40.PubMedGoogle Scholar
  6. Baer, L., Platman, S. R., and Fieve, R. R., 1970b, The role of electrolytes in affective disorders. Sodium, potassium, and lithium ions. Arch. Gen. Psychiat. 22:108.PubMedGoogle Scholar
  7. Baer, L., Platman, S. R., Kasser, S., and Fieve, R. R., 1971, Mechanism of renal lithium handling and their relationship of mineralocorticoids, J. Psychiat. 8:91.Google Scholar
  8. Baker, M. A., and Winokur, G., 1966, Cerebrospinal fluid lithium in manic illness, Brit. J. Psychiat. 112:163.PubMedGoogle Scholar
  9. Baldessarini, R., and Stephens, J., 1970, Lithium carbonate for affective disorders, Arch. Gen. Psychiat. 22:72.PubMedGoogle Scholar
  10. Black, D. H., and Milne, M. D., 1952, Experimental potassium depletion in man, Clin. Sci. 11:397.PubMedGoogle Scholar
  11. Bleiweiss, H., 1970, Salt supplements with lithium. Lancet 1:416.PubMedGoogle Scholar
  12. Bunney, W. E., Jr., and Davis, J. M., 1965, Norepinephrine in depressive reactions. A review. Arch. Gen. Psychiat. 13:483.Google Scholar
  13. Bunney, W. E., Jr., Goodwin, F., Davis, J. M., and Fawcett, J., 1968, A behavioral-biochemical study of lithium treatment, Am. J. Psychiat. 125:499.PubMedGoogle Scholar
  14. Cade, J. F. J., 1949, Lithium salts in the treatment of psychotic excitement, Med. J. Australia 2:349.PubMedGoogle Scholar
  15. Cade, J. F. J., 1970, Lithium, Sci. Proc. Am. Psychiat. Assoc. 123:155.Google Scholar
  16. Caldwell, H., Westlake, W. J., Connor, S., and Flanagan, T., 1971, A pharmacokinetic analysis of lithium carbonate absorption from several formulations in man, J. Clin. Pharmacol. 11:349.Google Scholar
  17. Carroll, B. J., and Sharp, P. T., 1971, Rubidium and lithium: opposite effects on amine- mediated excitement, Science 172:1355.PubMedGoogle Scholar
  18. Colburn, R., Goodwin, F., Bunney, W. E., Jr., and Davis, J. M., 1967, Effect of lithium on the uptake of noradrenaline by synaptosomes. Nature 215:1395.PubMedGoogle Scholar
  19. Coppen, A., and Shaw, D. M., 1967, The distribution of electrolytes and water in patients after taking lithium carbonate, Lancet 2:805.PubMedGoogle Scholar
  20. Coppen, A., Malleson, A., and Shaw, D. M., 1965, Effects of lithium carbonate on electrolyte distribution in man. Lancet 1:682.PubMedGoogle Scholar
  21. Coppen, A., Shaw, D. M., Malleson, A., and Costain, R., 1966, Mineral metabolism in mania, Brit. Med. J. 1:11.Google Scholar
  22. Corrodi, H., Fuxe, L., Hokfelt, T., and Schou, M., 1967, The effect of lithium on cerebral monoamine neurons, Psychopharmacologia 11:345.PubMedGoogle Scholar
  23. Corrodi, H., Fuxe, K., and Schou, M., 1969, The effect of prolonged lithium administration on cerebral monoamine neurons in the rat, Life Sci. 8:643.PubMedGoogle Scholar
  24. Cox, C., Harrison-Read, P. E., Steinberg, H., and Tomkiewicz, M., 1971, Lithium attenuates drug-induced hyperactivity in rats. Nature 232:336.PubMedGoogle Scholar
  25. Crammer, J. L., 1962, Electrolytes and mental state, in: Aspects of Psychiatric Research (D. Richter, ed.), Oxford University Press, New York.Google Scholar
  26. Crammer, J. L., 1970, Renal effects of lithium and calcium and the control of mania. Collegium Internationale Neuropsychopharmacologicum 7:93.Google Scholar
  27. Davenport, V. D., 1950, Distribution of parenterally administered lithium in plasma, brain, and muscle of rats, Am. J. Physiol 163:633.PubMedGoogle Scholar
  28. DeFeudis, F. V., and Delgado, J., 1970, Effect of lithium on amino acid in mouse brain in vivo, Nature 225:749.PubMedGoogle Scholar
  29. Delgado, J. M., 1969, Effects of lithium injections into the amygdala and hippocampus of awake monkeys, Exptl. Neurol. 25:255.Google Scholar
  30. Demers, R., and Heninger, G., 1970, Prelibial edema and sodium retention during lithium carbonate treatment, J. Am. Med. Assoc. 214:1845.Google Scholar
  31. Demers, R., and Heninger, G., 1971, Sodium intake and lithium treatment in mania. Am. J. Psychiat. 128:132.Google Scholar
  32. D’Encarnacao, P. S., and Anderson, K., 1970, Effect of lithium pretreatment on amphetamine and DMI tetrabenazine-produced psychomotor behavior. Diseases Nervous System 31:494.Google Scholar
  33. DeVanzo, J. P., 1968, Pharmacological and biological comparison of lithium and reference antidepressants. Pharmacologist 10:168.Google Scholar
  34. Dostal, T., and Zvolsky, P., 1971, Antiaggressive treatment of lithium in oligophrenic adolescents. Am. Coll. Neuropsychopharmacol. Abst. 1:121.Google Scholar
  35. Doüsa, T., and Hechter, O., 1970, Lithium and brain adenyl cyclase. Lancet 1:834.PubMedGoogle Scholar
  36. Epstein, R., Grant, L., Herjanic, M., and Winokur, G., 1965, Urinary excretion of lithium in mania, J. Am. Med. Assoc. 192:409.Google Scholar
  37. Fann, W. E., Davis, J. M., Janowsky, D. S., Cavanaugh, J. H., Kaufmann, J. S., Griffith, J. D., and Oates, J. A., 1972, The effects of lithium on adrenergic function in man, Clin. Pharm. Therap. 13:71.PubMedGoogle Scholar
  38. Foulks, J., Mudge, G., and Gilman, A., 1952, Renal excretion of cation in the dog during infusion of isotonic solutions of lithium chloride. Am. J. Physiol. 168:642.PubMedGoogle Scholar
  39. Fyro, B., Petterson, V., and Sedvall, G., 1970, Serum lithium levels and side effects during administration of lithium carbonate and two slow release lithium preparations to human: volunteers, Pharmacol Clin. 2:236.Google Scholar
  40. Geisler, A., Schou, M., and Thomsen, K., 1971, Renal lithium elimination in manic-depressive patients—Initial excretion and clearance, Pharmacopsychiatry 10:149.Google Scholar
  41. Gottesfeld, Z., Epstein, B. S., and Samuel, D., 1971, Effects of lithium in concentrations of glutamate and GABA levels in amygdala and hypothalamus. Nature New Biol. 234: 124.PubMedGoogle Scholar
  42. Greenspan, K., 1968, Clinical pharmacology and pending biochemical questions of lithium therapy. Diseases Nervous System 29:178.Google Scholar
  43. Greenspan, K., Goodwin, F., and Bunney, W. E., Jr., 1968a, Lithium ion retention and distribution: patterns during acute mania and normothymia. Arch. Gen. Psychiat. 19:664.PubMedGoogle Scholar
  44. Greenspan, K., Green, R., and Durrell, J., 1968b, Retention and distribution patterns of lithium: A pharmacological tool in studying the pathophysiology of manic-depressive psychosis. Am. J. Psychiat. 125:512.PubMedGoogle Scholar
  45. Greenspan, K., Schildkraut, J., Gordon, E., Levy, B., and Durrell, J., 1969, Catecholamine metabolism in affective disorders. Arch. Gen. Psychiat. 21:710.PubMedGoogle Scholar
  46. Greenspan, K., Aronoff, M. S., and Bogdanski, D. F., 1970, Effect of lithium carbonate on turnover and metabolism of norepinephrine in the rat brain. Pharmacology 3:129.Google Scholar
  47. Harris, C. A., and Jenner, F. A., 1969a, The inhibition of the action of vasopressin by lithium ions, J. Physiol. 200:59.Google Scholar
  48. Harris, C. A., and Jenner, F. A., 1969b, The ionic specificity of lithium as an inhibitor of the action of vasopressin, J. Physiol. 203:73.Google Scholar
  49. Ho, A. K. S., Gershon, S., and Pinckney, L., 1970, The effects of acute and prolonged lithium treatment on the distribution of electrolytes, potassium, and sodium. Arch. Int. Pharmacodyn. 186:54.PubMedGoogle Scholar
  50. Hullin, R. P., McDonald, R., and Dransfield, G. A., 1968a, Metabolic balance studies on the effects of lithium salts in manic-depressive psychosis, in: Proc. IV World Congr. Psychiat. (J. J. Lopezlbor, ed.), pp. 1900–1903, Excerpta Medica Foundation, I. C. S. 150, Amsterdam.Google Scholar
  51. Hullin, R. P., Swinscoe, J., McDonald, R., and Dransfield, G. A., 1968b, Metabolic balance studies on the effect of lithium salts in manic-depressive psychosis, Brit. J. Psychiat. 114: 1561.PubMedGoogle Scholar
  52. Katz, R. L, Chase, T. N., and Kopin, I. J., 1968, Evoked release of norepinephrine and serotonin from brain slices: inhibition by lithium. Science 162:466.PubMedGoogle Scholar
  53. King, L. J., and Carl, J., 1967, Lithium ion effects on brain in vivo, Federation Proc. 26:3104.Google Scholar
  54. King, L. J., Carl, J., and Venson, V., 1969, Effects of lithium on brain energy reserves and cations in vivo, J. Pharmacol. Exptl. Therap. 168:163.Google Scholar
  55. Kiseleva, I. P., and Lapin, I. P., 1969, Antagonistic effect of lithium carbonate on 5-hydroxy-tryptophan-induced head twitches in mice, Pharmacol. Res. Commun. 1:108.Google Scholar
  56. Kiseleva, I. P., Lapin, L P., Oxenkrugal, G. F., and Samsonova, M. L., 1971, Serotonin- ergic component of lithium activity. Collegium Internationale Neuropsychophormo- cologicum Abst. 2:239.Google Scholar
  57. Kopin, L, 1969, How does lithium work? New Engl. J. Med. 280:560.PubMedGoogle Scholar
  58. Krall, A. R., 1967, Potassium and sodium-like effects of lithium on brain mitochondrial phosphorylation. Life Sci. 6:1339.PubMedGoogle Scholar
  59. Krulik, R., 1971, Effect of lithium on aldosterone production by rat adrenals, Arzneimittel-Forsch. 6:889.Google Scholar
  60. Krulik, R., and Zvolsky, P., 1970, The influences of lithium ions on adrenocortical function of rats, Arzneimittel-Forsch. 20:1577.Google Scholar
  61. Kuriyama, K., and Speken, R., 1970, Effect of lithium on content and uptake of norepinephrine and 5-hydroxytryptamine in mouse brain synaptosomes and mitochondria. Life Sci. 9:1213.Google Scholar
  62. Lapin, L, 1969, Lithium and cerebral metabolism. New Engl. J. Med. 281:218.PubMedGoogle Scholar
  63. Lynn, E., 1970, Mania and the use of lithium. Sci. Sum. Am. Psychiat. Assoc. 123:252.Google Scholar
  64. Maggs, R., 1968, Electrolyte changes in lithium therapy (mania), in: Proc. IV World Cong. Psychiat. (J. J. Lopez-Ibor, ed.), pp. 2211–2214, Excerpta Medica Foundation, I C. S. 150, Amsterdam.Google Scholar
  65. Mangoni, A., Andreoli, V., Cabibbe, F., and Mandelli, V., 1970, Body fluid distribution in manic and depressed patients treated with lithium carbonate. Acta Psychiat. Scand. 46:244.PubMedGoogle Scholar
  66. Matussek, N., and Linsmayer, 1968, The effect of lithium and amphetamine of desmethylimipramine-Ro-4–1284-induced motor hyperactivity. Life Sci. 7:371.PubMedGoogle Scholar
  67. Morrison, J. M., Pritchard, H., Braude, M., and D’Aguannot, W., 1971, Plasma and brain lithium levels after lithium carbonate and lithium chloride administration by different routes in rats, Proc. Soc. Exptl. Biol. Med. 137:889.Google Scholar
  68. Murphy, D. L., and Bunney, W. E., Jr., 1971, Total body potassium changes during lithium administration, J. Nervous Mental Disease 152:381.Google Scholar
  69. Murphy, D. L., Colburn, R., Davis, J. M., and Bunney, W. E., Jr., 1969a, Lithium stimulation of monoamine uptake in human platelets. Life Sci. 8:1189.Google Scholar
  70. Murphy, D. L., Goodwin, F. K., and Bunney, W. E., Jr., 1969b, Aldosterone and sodium response to lithium administration in man. Lancet 2:458.PubMedGoogle Scholar
  71. Neilsen, J., 1964, Magnesium-lithium studies 1. Serum and erythrocyte magnesium in patients with manic states during lithium treatment, Acta Psychiat. Scand. 40:190.Google Scholar
  72. Perez-Cruet, J., Tagliamonte, A., Tagliamonte, P., and Gessa, G., 1971, Stimulation of serotonin synthesis by lithium, J. Pharmacol. Exptl. Therap. 178:325.Google Scholar
  73. Perkinson, E., 1969, Pharmacological and biochemical comparison of lithium and reference antidepressants, Proc. Soc. Experimental Biol. Med. 131:685.Google Scholar
  74. Persson, G., 1971, Effects of a sustained-release lithium preparation. Acta Psychiat. Scand. Suppl. 221:33.Google Scholar
  75. Platman, S. R., and Fieve, R., 1968a, Biochemical aspects of lithium in affective disorders. Arch. Gen. Psychiat. 9:659.Google Scholar
  76. Platman, S. R., and Fieve, R., 1968b, Lithium carbonate and plasma Cortisol response in the affective disorders. Arch. Gen. Psychiat. 18:594.Google Scholar
  77. Platman, S. R., and Fieve, R., 1969, Lithium retention and excretion. Arch. Gen. Psychiat. 20:285.PubMedGoogle Scholar
  78. Platman, S. R., Rohrlich, J., and Fieve, R., 1968, absorption and excretion of lithium in manic-depressive disease, Diseases Nervous System 29:733.Google Scholar
  79. Platman, S. R., Fieve, R., and Pierson, R. N., 1970, Effect of mood and lithium carbonate on total body potassium. Arch. Gen. Psychiat. 22:297.PubMedGoogle Scholar
  80. Prien, R. F., Caifey, Z. M., and Klett, J., 1971, The relationship between serum lithium levels and clinical response in acute manics treated With lithium carbonate. Cooperative Studies in Psychiatry, Report No. 91, VA-NIMH Collaborative Study Group, Perry Point, Maryland.Google Scholar
  81. Radomski, J. L., Fuyat, H. N., and Nelson, A. A., 1950, The toxic effects, excretion and distribution of lithium chloride, J. Pharmacol. Exptl. Therap. 100:429.Google Scholar
  82. Sachar, E., 1970, Effect of lithium carbonate therapy on adrenocortical activity. Arch. Gen. Psychiat. 22:304.PubMedGoogle Scholar
  83. Saran, B. M., 1970, Biochemical and clinical effects of lithium carbonate in manic-depressive psychoses. Collegium Internationale Neuropsychopharmacologicum Abst. 7:383.Google Scholar
  84. Schanberg, S. M., Schildkraut, J.J., and Kopin, L. J., 1967, The effects of psychoactive drugs on norepinephrine metabolism in the brain, Biochem. Pharmacol. 16:393.PubMedGoogle Scholar
  85. Schildkraut, J. J., 1965, The catecholamine hypothesis of affective disorders: A review of supporting evidence, Am. J. Psychiat. 122:509.PubMedGoogle Scholar
  86. Schildkraut, J. J., Schanberg, S. M., and Kopin, I. J., 1966, The effects of lithium ion on H-norepinephrine metabolism in brain. Life Sci. 5:1479.PubMedGoogle Scholar
  87. Schildkraut, J. J., Davis, J., and Klerman, G., 1968, Biochemistry of depressions, in: Psychopharmacology, A Review of Progress (D. Efron, J. Cole, J. Levine, and J. R. Wittenborn, eds.), pp. 625–648, Public Health Service Publ. 1836, U.S. Government Printing Office, Washington, D. C.Google Scholar
  88. Schildkraut, J. J., Logue, M. A., and Dodge, G. A., 1969a, The effects of lithium salts on the turnover and metabolism of norepinephrine in rat brain, Psychopharmacologia 14:135.PubMedGoogle Scholar
  89. Schildkraut, J. J., Schanberg, S., Breese, S., and Kopin, I., 1969b, Effect of psychoactive drugs on the metabolism of intracisternally administered serotonin in rat brain, Biochem. Pharm. 18:1971.PubMedGoogle Scholar
  90. Schou, M., 1957, Biology and pharmacology of the lithium ion, Pharmacol. Rev. 1:17.Google Scholar
  91. Schou, M., 1958a, Lithium studies. 1. Toxicity, Acta Pharmacol. Toxicol. 15:70.Google Scholar
  92. Schou, M., 1958b, Lithium studies. 2. Renal elimination. Acta Pharmacol. Toxicol. 15:85.Google Scholar
  93. Schou, M., 1958c, Lithium studies. 3. Distribution between serum and tissues. Acta Pharmacol. Toxicol. 15:115.Google Scholar
  94. Schou, M., 1966, The metabolism and biochemistry of lithium, in: International Symposium on Antidepressant Drugs (S. Garattini and M. N. G. Dukes, eds), pp. 80–83. Excerpta Medica Foundation, Amsterdam.Google Scholar
  95. Schou, M., 1969a, Lithium: elimination rate, dosage, control, poisoning, goiter mode of action. Acta Psychiat. Scand. Suppl. 207:49.Google Scholar
  96. Schou, M., 1969b, Lithium: relation between clinical effects of the drug and its absorption, distribution and excretion, in: The Present Status of Psychotropic Drugs (A. Cerletti and F. S. Bove, eds.), pp. 120–122, Excerpta Medica Foundation, Amsterdam.Google Scholar
  97. Sedvall, G., 1969, Discussion, Acta Psychiat. Scand. Suppl. 207:57.Google Scholar
  98. Sedvall, B., Petterson, V., and Fyro, B., 1970, Individual differences in serum levels of lithium in human subjects receiving fixed doses of lithium carbonate. Relation of renal lithium clearance and body weight, Pharmacol. Clin. 2:231.Google Scholar
  99. Serry, M., 1969a, Lithium retention and response. Lancet 1:1267.PubMedGoogle Scholar
  100. Serry, M., 1969b, The lithium excretion test, Australian-New Zealand J. Psychiat. 3:390.Google Scholar
  101. Shaw, D. M., 1966, Mineral metabolism, mania, and melancholia, Brit. Med. J. 2:262.PubMedGoogle Scholar
  102. Shaw, D. M., and Coppen, A., 1966, Potassium and water distribution in depression, Brit. J. Psychiat. 112:269.PubMedGoogle Scholar
  103. Sheard, M.H., 1970a, Behavioral effects of p-chlorophenylalanine in rats: inhibition by lithium, Commun. Behav. Biol. 5:71.Google Scholar
  104. Sheard, M.H., 1970b, Effect of lithium in foot shock aggression in rats. Nature 228:284.PubMedGoogle Scholar
  105. Sheard, M.H., 1971, Effect of lithium on human aggression, Nature 230:113.PubMedGoogle Scholar
  106. Sheard, M. H., and Aghajanian, G. K., 1970, Activated metabolism of brain serotonin, Life Sci 9:285.PubMedGoogle Scholar
  107. Sletten, J. W., and Gershon, S., 1966, The effects of chlorpromazine on water and electrolyte balance, J. Nervous Mental Disease 142:25.Google Scholar
  108. Sletten, J. W., Pichardo, J., Korol, B., and Gershon, S., 1966, The effect of chlorpromazine on lithium excretion in psychiatric subjects. Current Therap. Res. 8:441.Google Scholar
  109. Solomon, S., 1967, Action of alkali metals on papillary cortical sodium gradient of dog kidney, Proc. Soc. Exptl. Biol Med. 125:1183.Google Scholar
  110. Stancer, N. C., and Kivi, R., 1971, Lithium carbonate and edema. Lancet 2:985.PubMedGoogle Scholar
  111. Stern, D. M., Fieve, P. R., Neff, N. H., and Costa, E., 1969, The effects of lithium chloride administration on brain and heart norepinephrine turnover rates, Psychopharmacologia 14:315.PubMedGoogle Scholar
  112. Stokes, J. W., Mendels, J., and Secunda, S. K., 1970, Predicting clinical response to lithium, Sci. Proc. Am. Psychiat. Assoc. 123:157.Google Scholar
  113. Stokes, J. W., Mendels, J., Secunda, S. K., and Dyson, W. L., 1972, Lithium excretion and therapeutic response, J. Nervous Mental Disease 154:43.Google Scholar
  114. Tagliamonte, A., Tagliamonte, P., Perez-Cruet, J., and Gessa, G., 1971, Increase of brain tryptophan caused by drugs which stimulate serotonin synthesis. Nature New Biol. 229: 125.PubMedGoogle Scholar
  115. Talso, P. J., and Clarke, R. W., 1951, Excretion and distribution of lithium in the dog. Am. J. Physiol. 166:202.PubMedGoogle Scholar
  116. Thomsen, K., 1969, Renal lithium elimination in man and active treatment of lithium poisoning. Acta Psychiat. Scand. Suppl. 207:83.Google Scholar
  117. Thomsen, K., and Schou, M., 1968, Renal lithium excretion in man. Am. J. Physiol. 215: 823.PubMedGoogle Scholar
  118. Thomsen, K., Schou, M., Steiness, L, and Hansen, H.E., 1969, Lithium as an indicator of proximal sodium reabsorption. Pfluegers Arch. Ges. Physiol. 308:180.Google Scholar
  119. Trautner, E. M., Morris, R., Noack, C. H., and Gershon, S., 1955, The excretion and retention of ingested lithium and its effect on the ionic balance of man, Med. J. Australia 2:280.Google Scholar
  120. Tupin, J. P., Schlagenhauf, G. K., and Creson, D. L., 1968, Lithium effects on electrolyte excretion. Am. J. Psychiat. 125:536.PubMedGoogle Scholar
  121. U’Prichard, D. C., and Steinberg, H., 1972, Selective effects of lithium on two forms of spontaneous activity, Brit. J. Pharmacol. 44:349.Google Scholar
  122. Van der Velde, C., and Gordon, M., 1969, Manic-depressive illness, diabetes mellitus, and lithium carbonate. Arch. Gen. Psychiat. 21:478.PubMedGoogle Scholar
  123. Weischer, M. L., 1969, About the antiaggressive effect of lithium, Psychopharmacologia 15:245.PubMedGoogle Scholar
  124. Weischer, M. L., and Opitz, K., 1970, Abschwachung analgetischer Effekte durch Lithium, Arzneimittel-Forsch. 20:1046.Google Scholar
  125. Zvolsky, P. and Grof, P., 1968, Clinical factors determining the serum lithium concentration, Activitas Nervosa Sup. 10:292.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • John M. Davis
    • 1
  • David S. Janowsky
    • 1
  • Khaled El-Yousef
    • 1
  1. 1.Tennessee Neuropsychiatric InstituteCentral State HospitalNashvilleUSA

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