Abstract
Water plays many roles during the course of an enzymatic reaction. Its importance in maintaining the structural integrity of proteins has been emphasized repeatedly; water is also directly involved in many reactions as either a reactant or product. Additionally, there are more subtle effects of water influencing the ionization of charged groups, directing tertiary structure through interaction with hydrophobic and hydrophilic side-chains, binding at definite sites, and displacement during the course of reaction (1, 2).
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References
Steitz, T. A., Henderson, R., and Blow, D. M., J. Mol. Biol. 46, 337 (1969).
Blake, C. C. F., Mair, G. A., North, A. C. T., Phillips, D. C., and Sarma, V. R., Proc. Roy. Soc. Ser. B 167, 365 (1967).
Ibanez, J. D., Kimball, A. P., and Oro, J., Science 173, 444 (1971).
Fox, S. W. and Harada, K., Science 128, 1214 (1958).
Rohlfing, D. L. and Fox, S. W., Arch. Biochem. Biophys. 118, 122 (1967).
Fox, S. N., Nature 201, 336 (1964).
Pimentel, G. C., Atwood, K. C., Gaffron, H., Hartline, H. K., Jukes, T. H., Pollard, E. C., and Sagan, C., in “Biology and the Exploration of Mars,” p. 243. National Academy of Sciences, Washington, 1966.
Skujins, J. J. and McLaren, A. D., Science 158, 1569 (1967).
Dastoli, F. R., Musto, N. A., and Price, S., Arch. Biochem. Biophys. 115, 44 (1966).
Dastoli, F. R. and Price, S., Arch. Biochem. Biophys. 118, 163 (1967).
Dastoli, F. R. and Price, S., Arch. Biochem. Biophys. 122, 289 (1967).
Siegel, S. M. and Roberts, K., Space Life Sciences 1, 131 (1968).
Rees, E. D. and Singer, S. J., Arch. Biochem. Biophys. 63, 144 (1956).
Heinrich, M. R. and Mack, R., Federation Proc. 27, 786 (1968).
Rammler, D. H., Ann. N. Y. Acad. Sci. 141, 291 (1967).
Bugna, E. and Heinrich, M. R., to be published.
Mares-Guia, M. and Shaw, E., J. Biol. Chem. 240, 1579 (1965).
Seydoux, F., Yon, J., and Nemethy, G., Biochim. Biophys. Acta 171, 145 (1969).
Inada, Y., Kamata, M., Matsushima, A., and Shibata, K., Biochim. Biophys. Acta 81, 323 (1964).
Herskovits, T. T. and Villanueva, G. B., Arch. Biochem. Biophys. 131, 321 (1969).
Mares-Guia, M. and Figueiredo, A. F. S., Biochemistry 9, 3223 (1970).
Mack, R. and Heinrich, M. R., Federation Proc. 30, 1077 (1971).
Tanford, C., Adv. Prot. Chem. 23, 121 (1968).
Timasheff, S. N. and Inoue, H., Biochemistry 7, 2501 (1968).
Hamaguchi, K., J. Biochem. (Tokyo) 56, 441 (1964).
Herskovits, T. T., J. Biol. Chem. 240, 628 (1965).
Timasheff, S. N., Accounts Chem. Res. 3, 62 (1970).
Inagami, T. and Sturtevant, J. M., Biochim. Biophys. Acta 38, 64 (1960).
Deal, P. H., Cryobiology 7, 107 (1970).
Hochstein, L. I. and Dalton, B. P., J. Bacteriol. 95, 37 (1968).
Lanyi, J. K. and Stevenson, M. J., J. Biol. Chem. 245, 4074 (1970).
Fahnestock, S. and Rich, A., Science 173, 340 (1971).
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Heinrich, M.R. (1972). Solvent Effects on Enzymes: Implications for Extraterrestrial Life. In: Rohlfing, D.L., Oparin, A.I. (eds) Molecular Evolution. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2019-7_26
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DOI: https://doi.org/10.1007/978-1-4684-2019-7_26
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