Advertisement

Myeloperoxidase, the Peroxidase of a Primitive Cell; Its Reaction with Fe and H2O2

  • Julius Schultz
  • S. Rosenthal

Abstract

Evidence that mitochondria appeared sometime during the evolution of the cell as a result of a symbiotic bacteria which eventually became an integral part of the cellular structure has been reviewed by Sagan (1). If one stops to think about the system of terminal oxidation in the premitochondrial age, one might look to the peroxidases. Peroxidases require hydrogen peroxide, with which they combine to oxidize a large variety of substrates which serve as donors. It is the diversity and widespread chemical structures which can be peroxidized which makes them excellent candidates for the role of terminal oxidases. The fact that flavins, DPNH, and oxygen, which were early cellular constituents, react with the formation of hydrogen peroxide serves well for this concept.

Keywords

Ammonium Sulfate Ferric Sulfate Native Enzyme Prosthetic Group Peptide Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sagan, L., J. Theor. Bio., 14, 225 (1967).CrossRefGoogle Scholar
  2. 2.
    Saunders, B. C., “Peroxidase,” Butterworth, Washington, 1964.Google Scholar
  3. 3.
    Hager, L. P., in “Biochemistry of the Phagocytic Process,” (J. Schultz, ed.), North Holland Publ., Amsterdam, 1970.Google Scholar
  4. 4.
    Zgliczynski, J. M., Stelmaszynska, T., Ostrowski, W., Naskalski, J., and Sznajd, J., Eur. J. Bioch. 4, 540 (1968).CrossRefGoogle Scholar
  5. 5.
    Klebanoff, S. J., In “Biochemistry of the Phagocytic Process,” ( J. Schultz, ed.), North Holland Publ., Amsterdam, 1970.Google Scholar
  6. 6.
    Sbarra, A. J., Paul, B. B., Strauss, R. R., Jacobs, A. A., and Mitchell, G. W., Advances in Exper. Med. 8, Biol. 15, 2 09 (1960). Schultz, J., and Shmukler, H., Biochem. 3, 1234 (1964).Google Scholar
  7. 8.
    Schultz, J., and Rosenthal, S., J. Biol. Chem. 234, 2486 (1959).PubMedGoogle Scholar
  8. 9.
    Schultz, J., and Rosenthal, S., ABSTR. Amer. Chem. Soc. 137, 35 c (1960).Google Scholar
  9. 10.
    Baker, A., and Schultz, J., Federation Proc. 22, 587 (1963).Google Scholar
  10. 11.
    Baker, A., and Schultz, J., ABSTR. Amer. Chem. Soc. 145, 49 c (1963).Google Scholar
  11. 12.
    Drabkin, D. L., J. Biol. Chem. 140, 387 (1940).Google Scholar
  12. 13.
    Gomori, G., J. Lab. Clin. Med. 27, 955 (1942).Google Scholar
  13. 14.
    Schultz, J., Gordon, A., and Shay, H., J. Am. Chem. Soc. 79, 1632 (1957).CrossRefGoogle Scholar
  14. 15.
    Schultz, J., Shay, H., and Gruenstein, M., Cancer Res. 14, 157 (1954).PubMedGoogle Scholar
  15. 16.
    Rigg, T., Taylor, W., and Weiss, J., J. Chem. Phys. 22, 575 (1954).CrossRefGoogle Scholar
  16. 17.
    Agner, K., Acta. Chem. Scan. 17, 332 (1963).CrossRefGoogle Scholar
  17. 18.
    Paul, K. G., The Enzymes 8, 262 (1963).Google Scholar
  18. 19.
    Weiss, J., Experientia 9, 61 (1953).PubMedCrossRefGoogle Scholar
  19. 20.
    King, J., and Davidson, N., J. Am. Chem. Soc. 80, 1542 (1958).CrossRefGoogle Scholar
  20. 21.
    Taube, H., in “Oxygen” (Symposium, N. H. Heart Association), p. 29. Little, Brown & Co., Boston, 1965.Google Scholar
  21. 22.
    Beinert, H., The Enzymes 2, 339 (1963).Google Scholar
  22. 23.
    Hiromi, K., and Sturtevant, J., J. Biol. Chem. 240, 4662 (1965).PubMedGoogle Scholar
  23. 24.
    Yates, M. G., and Nason, A., J. Biol. Chem. 241, 4861 (1966).PubMedGoogle Scholar
  24. 25.
    Bonner, M. J., and Schultz, J., ABSTR., Federation Proc., March-April, 26 (1967).Google Scholar
  25. 26.
    Taborsky, G., and Grant, C. T., Biochemistry 5, 544 (1966).PubMedCrossRefGoogle Scholar
  26. 27.
    Schultz, J., Felberg, N., and John, S., Biochem. Biophys. Res. Comm. 28, 543 (1967).CrossRefGoogle Scholar
  27. 28.
    Schultz, J., and Felberg, N., Anal. Biochem. 23, 241 (1968).PubMedCrossRefGoogle Scholar
  28. 29.
    Felberg, N., and Schultz, J., Arch. Biochem. Biophys. 148, 407 (1972).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press 1972

Authors and Affiliations

  • Julius Schultz
    • 1
    • 2
  • S. Rosenthal
    • 1
  1. 1.Papanicolaou Cancer Research InstituteMiamiUSA
  2. 2.Papanicolaou Cancer Research InstituteMiamiUSA

Personalised recommendations