Myeloperoxidase, the Peroxidase of a Primitive Cell; Its Reaction with Fe and H2O2

  • Julius Schultz
  • S. Rosenthal


Evidence that mitochondria appeared sometime during the evolution of the cell as a result of a symbiotic bacteria which eventually became an integral part of the cellular structure has been reviewed by Sagan (1). If one stops to think about the system of terminal oxidation in the premitochondrial age, one might look to the peroxidases. Peroxidases require hydrogen peroxide, with which they combine to oxidize a large variety of substrates which serve as donors. It is the diversity and widespread chemical structures which can be peroxidized which makes them excellent candidates for the role of terminal oxidases. The fact that flavins, DPNH, and oxygen, which were early cellular constituents, react with the formation of hydrogen peroxide serves well for this concept.


Ammonium Sulfate Ferric Sulfate Native Enzyme Prosthetic Group Peptide Fraction 
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Copyright information

© Plenum Press 1972

Authors and Affiliations

  • Julius Schultz
    • 1
    • 2
  • S. Rosenthal
    • 1
  1. 1.Papanicolaou Cancer Research InstituteMiamiUSA
  2. 2.Papanicolaou Cancer Research InstituteMiamiUSA

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