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Syntheses and Conformational Studies of Polyacidic Amino Acids Containing Optical Active Side Chains

  • Tadao Hayakawa
  • Hiroyuki Yamamoto

Abstract

The syntheses and physicochemical properties of poly ( β-alkyl aspartate) and poly( γ-alkyl glutamate) have been widely investigated (1–11). Optical rotatory dispersion (ORD) and circular dichroism (CD) have led to the conclusion that many L-polypeptides have a right-handed helical sense. Poly( γ-alkyl L-glutamate) assumes a right-handed helical conformation in a solvent such as chloroform, while it assumes a disordered conformation in a solvent such as dichloroacetic acid (DCA) or trifluoroacetic acid (TFA). Polymers of β-methyl and β-benzyl L-aspartates represent exceptions to the general rule and exist as left-handed helices in chloroform and in methylene dichloride solutions. The introduction of a nitro, methyl, chloro, or cyano group into the para position of the aromatic ring in the side chain of poly( β-benzyl L-aspartate) causes a reversal of the left-handed helix of the poly- α-amino acid in chloroform (12, 13). In addition, poly( β-benzyl L-aspartate) is known to undergo a polymorphic transition from the α-helix to the ω-helix when a solid film is heated in vacuo (14).

Keywords

Circular Dichroism Random Coil Random Coil Structure Coil Transition Optical Rotatory Dispersion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1972

Authors and Affiliations

  • Tadao Hayakawa
    • 1
  • Hiroyuki Yamamoto
    • 1
  1. 1.Institute of High Polymer Research, Faculty of Textile Science and TechnologyShinshu UniversityUedaJapan

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