Skip to main content

Synthesis of Glutamic Acid via Cyanoethylation of N-Acylaminoacetonitriles in Liquid Ammonia

  • Chapter
Molecular Evolution

Abstract

Several reports on the prebiotic formation of amino acids have been previously published. Glutamic acid was synthesized from a mixture of simple gases by electric discharge (1, 2) and by heat (3). Glutamic acid was also formed from hydrogen cyanide and ammonia (4), from formaldehyde, ammonium chloride, and ammonium nitrate under irradiation of ultraviolet rays (5), by pyrolysis of formamide (6), and by pyrolysis of a reaction product of formaldehyde and ammonia (7).

Contribution no. 200 of the Institute for Molecular and Cellular Evolution, University of Miami.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Miller, S. L., J. Am. Chem. Soc. 77, 2351 (1955).

    Article  CAS  Google Scholar 

  2. Grossenbacher, K. H., and Knight, C. A., in “The Origins of Prebiological Systems,” (S. N. Fox, ed.), p. 173. Academic Press, New York, 1965.

    Google Scholar 

  3. Harada, K., and Fox, S. W., Nature 201, 335 (1964).

    Article  PubMed  CAS  Google Scholar 

  4. Oro, J., and Kamat, S. S., Nature 190, 442 (1961).

    Article  PubMed  CAS  Google Scholar 

  5. Lowe, C. U., Rees, M. W., and Markham, R., Nature 199, 219 (1963).

    Article  PubMed  CAS  Google Scholar 

  6. Pavlovskaya, T. E., and Pasynskii, A. G., in “The Origin of Life on Earth,” I.U.B. Symposium Series I, p. 151. Pergamon Press, New York, 1959.

    Google Scholar 

  7. Harada, K., Nature 214, 479 (1967).

    Article  CAS  Google Scholar 

  8. Fox, S. W., and Windsor, C. R., Science 27, 984 (1971).

    Google Scholar 

  9. Morrison, D. C., J. Am. Chem. Soc. 77, 6072 (1955).

    Article  CAS  Google Scholar 

  10. Moe, O. A., et al., U.S.P. 2, 551, 566 (1951).

    Google Scholar 

  11. Akabori, S., Kagaku 25, 54 (1955).

    CAS  Google Scholar 

  12. Akabori, S., “The Origin of Life on the Earth,” I. U. B. Symposium Series I, p. 189. Pergamon Press, New York, 1959.

    Google Scholar 

  13. Furuyama, T., Sakiyama, F., and Narita, K., Bull Chem. Soc. Japan 36, 903 (1963).

    Article  CAS  Google Scholar 

  14. Sanger, F., Biochem. J. 39, 507 (1945).

    CAS  Google Scholar 

  15. Rao, K., and Sober, H. A., J. Amer. Chem. Soc. 76, 1328 (1954).

    Article  CAS  Google Scholar 

  16. Perrone, J. C., Nature 167, 513 (1951).

    Article  PubMed  CAS  Google Scholar 

  17. Court, A., Biochem. J. 58, 70 (1954).

    Google Scholar 

  18. Harada, K., and Matsumoto, K., J. Org. Chem. 32, 1794 (1967).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1972 Plenum Press

About this chapter

Cite this chapter

Harada, K., Okawara, T. (1972). Synthesis of Glutamic Acid via Cyanoethylation of N-Acylaminoacetonitriles in Liquid Ammonia. In: Rohlfing, D.L., Oparin, A.I. (eds) Molecular Evolution. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2019-7_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2019-7_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2021-0

  • Online ISBN: 978-1-4684-2019-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics