Molecular Basis for the Action of Macrocyclic Carriers on Passive Ionic Translocation Across Lipid Bilayer Membranes

  • G. Eisenman
  • G. Szabo
  • S. G. A. McLaughlin
  • S. M. Ciani


Substantial energies in living cells are stored in ionic gradients across membranes. One of the central problems of biological energy transduction is that of understanding how these gradients arise and conversely, how the energy stored in such gradients is utilized to drive chemical reactions. These are two aspects of the reversible coupling of the energy of transmembrane ionic concentration gradients with the energy of chemical reactions—an electrochemical problem which may be thought of as involving, on the one hand, a mechanism for selective ion permeation and, on the other, a means of coupling that mechanism to the appropriate chemical reaction.


Membrane Conductance Alkali Metal Cation Conductance Ratio Phosphatidyl Ethanolamine Permeability Ratio 
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Copyright information

© Plenum Publishing Company Limited 1972

Authors and Affiliations

  • G. Eisenman
    • 1
  • G. Szabo
    • 1
  • S. G. A. McLaughlin
    • 1
  • S. M. Ciani
    • 1
  1. 1.Department of PhysiologyUCLA School of MedicineLos AngelesUSA

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