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ATP Synthesis in Oxidative Phosphorylation: A Direct-Union Stereochemical Reaction Mechanism

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Membrane Structure and Mechanisms of Biological Energy Transduction
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Abstract

A fundamental understanding of oxidative phosphorylation will involve chemical reaction mechanisms. Since chemical reaction mechanisms describe in detail the making and/or breaking of chemical bonds, before a meaningful reaction mechanism can be formulated for a given reaction, the actual bonds involved must be known. This applies to all chemical reactions, including the chemical reactions in oxidative phosphorylation.

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References

  1. For a recent review of oxidative phosphorylation see: H. A. Lardy and S. M. Ferguson, Ann. Rev. Biochem., 38 (1969) 991.

    Article  Google Scholar 

  2. R. D. Hill and P. D. Boyer, J. Biol. Chem., 242 (1967) 4320.

    PubMed  CAS  Google Scholar 

  3. D. H. Jones and P. D. Boyer, J. Biol. Chem., 244 (1969) 5767.

    PubMed  CAS  Google Scholar 

  4. P. D. Boyer, in: Biological Oxidations, T. P. Singer (ed.), Interscience, New York, 1968, p. 193.

    Google Scholar 

  5. P. D. Boyer, in: Current Topics in Bioenergetics, D. R. Sanadi (ed.), Vol. 2, Academic Press, New York, 1967, p. 99.

    Google Scholar 

  6. P. C. Chan, A. L. Lehninger and T. Enns, J. Biol. Chem., 235 (1960) 1790.

    PubMed  CAS  Google Scholar 

  7. R. A. Mitchell, R. D. Hill and P. D. Boyer, J. Biol. Chem., 242 (1967) 1793.

    PubMed  CAS  Google Scholar 

  8. R. Kluger, F. Covitz, E. Dennis, L. D. Williams and F. H. Westheimer, J. Amer. Chem. Soc., 91 (1969) 6066.

    Article  CAS  Google Scholar 

  9. F. H. Westheimer, Accounts Chem. Res., 1 (1968) 70.

    Article  Google Scholar 

  10. E. L. Muetterties, Accounts Chem. Res., 3 (1970) 266.

    Article  Google Scholar 

  11. E. L. Muetterties, W. Mahler and R. Schmutzler, Inorg. Chem., 2 (1963) 613.

    Article  CAS  Google Scholar 

  12. For the original presentation of this reaction mechanism, see: E. F. Korman and J. McLick, Proc. Nat. Acad. Sci. (U.S.), 67 (1970) 1130.

    Article  Google Scholar 

  13. For a treatment of the very important concept of tight substrate binding during enzyme catalysis, especially of reaction intermediates and transition states, see: R. Wolfenden, Accounts Chem. Res.,5 (1972) 10.

    Google Scholar 

  14. For a useful pictorial introduction to general reaction stereochemistry at tetrahedral substrates see: L. H. Sommer, Stereochemistry, Mechanism and Silicon, Chap. 11, McGraw-Hill, New York, 1965.

    Google Scholar 

  15. We predict that an analog of ATP in which the terminal P-O-P oxygen bridge atom is replaced by a methylene bridge (P-CHZ P) inert to enzymatic hydrolysis could, nevertheless, incorporate 180 from H218O into the terminal phosphorus center.

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  16. For an introduction to the important concept of proton involvement in biological oxidation-reduction mechanisms see: G. A. Hamilton in Progress in Bioorganic Chemistry,E. T. Kaiser and F. J. Kezdy, (eds.), Vol. 1, Interscience, New York, 1970, p. 83.

    Google Scholar 

  17. R. A. Harris, J. T. Pennington, J. Asai, and D. E. Green, Proc. Nat. Acad. Sci. (U.S.), 59 (1968) 830.

    Article  CAS  Google Scholar 

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© 1972 Plenum Publishing Company Limited

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Korman, E.F., McLick, J. (1972). ATP Synthesis in Oxidative Phosphorylation: A Direct-Union Stereochemical Reaction Mechanism. In: Avery, J. (eds) Membrane Structure and Mechanisms of Biological Energy Transduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2016-6_14

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  • DOI: https://doi.org/10.1007/978-1-4684-2016-6_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2018-0

  • Online ISBN: 978-1-4684-2016-6

  • eBook Packages: Springer Book Archive

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