Influence of Corticosterone and ACTH on the Postnatal Development of Learning and Memory Functions

  • Cs. Nyakas


In recent years, on the analogy of the hormonal background of sexual differentiation, attempts have been made to analyse the postnatal influence of adrenocortical hormones on the maturation of the psychoneuroendocrine processes. The influence of adrenocortical hormones as well as ACTH on the central nervous system have widely been studied in adult animals (Cleghorn 1957, Lissák and Endrőczi 1960, de Wied 1966, 1969).


Exploratory Activity Plasma Corticosterone Postnatal Development Plasma Corticosterone Level Acta Physiol 
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  1. Ader, R. (1970): The effect of early experience on the adrenocortical response to different magnitudes of stimulation. Physiol. Behav.5, 837–839.PubMedCrossRefGoogle Scholar
  2. Cleghorn, R. A. (1957): Steroid hormones in relation to neuropsychiatric disorders. In: Hormones. Brain Function, and Behavior. Ed. by H. Hoagland. Academic Press, New York. pp. 3–19.Google Scholar
  3. Denenberg, V. H., Brumaghim, J. T., Haltmeyer, G. C. and Zarrow, M. X. (1967): Increased adrenocortical activity in the neonatal rat following handling. Endocrinology81, 1047–1052.PubMedCrossRefGoogle Scholar
  4. Dupont, A., Endrőczi, E. and Fortier, C. (1970): Relationships of pituitary-thyroid and pituitary-adrenocortical activities to conditioned behaviour in the rat. In: Influence of Hormones on the Nervous System. Ed. by D. H. Ford. Karger, Basel and New York.Google Scholar
  5. Eguchi, Y. and Wells, L. (1965): Response of the hypothalamic-hypophyseal adrenal axis to stress: observation in fetal and caesarean newborn rats. Proc. Soc. exp. Biol. (N. Y.)120, 675–678.Google Scholar
  6. Endrőczi, E. (1970): Pituitary-adrenocortical activity, exploration and avoidance behaviour in the rat. UCLA Workshop Conference, Los Angeles. Ed. by C. H. Sawyer and R. Gorski. Univ. Calif. Press. (In press.)Google Scholar
  7. Endrőczi, E. and Tóth, K. (1955): Analytical studies on the ontogenetical development of humoral adaptation. Acta physiol. Acad. Sci. hung.8, 33–42.Google Scholar
  8. Endrőczi, E. and Nyakas, C. (1972): Correlation of pituitary-adrenal function to exploratory activity and passive avoidance learning in the rat. Acta physiol. Acad. Sci. hung. (In press.)Google Scholar
  9. Givner, M. and Rochefort, J. (1965): An improved assay of corticosterone in rat serum and adrenal tissue. Steroids6, 486–489.CrossRefGoogle Scholar
  10. Haltmeyer, G. C., Denenberg, V. H., Thatcher, J. and Zarrow, M. X. (1966): Response of the adrenal cortex of the neonatal rat after subjection to stress. Nature (Lond.)212, 1371–1373.CrossRefGoogle Scholar
  11. Jailer, J. W. (1950): The maturation of the pituitary-adrenal axis in the newborn rat. Endocrinology46, 420–425.PubMedCrossRefGoogle Scholar
  12. Levine, S. (1968): Influence of infantile stimulation on the response to stress during preweaning development. Developmental Psychobiology1, 67–70.CrossRefGoogle Scholar
  13. Levine, S. (1970): The pituitary-adrenal system and the developing brain. In: Progress in Brain Research. Vol. 32. Ed. by D. de Wied and J. A. W. M. Weijnen. Elsevier, Amsterdam. pp. 79–85.Google Scholar
  14. Levine, S., Haltmeyer, G. C., Karas, G. G. and Denenberg, V. H., (1967): Physiological and behavioral effects of infantile stimulation). Physiol. Behav.2, 55–59.CrossRefGoogle Scholar
  15. Lissák, K. and Endrőczi, E. (1960): Die neuroendokrine Steuerung der Adaptationstätigkeit. Akadémiai Kiadó, Budapest.Google Scholar
  16. McEwen, B. S. and Weiss, J. M. (1970): The uptake and action of corticosterone: regional and subcellular studies on rat brain. In: Progress in Brain Research. Vol. 32. Ed. by D. de Wied and J. A. W. M. Weijnen. Elsevier, Amsterdam. pp. 200–212.Google Scholar
  17. McEwen, B. S., Weiss, J. M. and Schwartz, L. (1969): Uptake of corticosterone by rat brain and its concentration by certain limbic structures. Brain Res.16, 227–241.PubMedCrossRefGoogle Scholar
  18. Milkovic, K. and Milkovic, S. (1959): Reactiveness of the pituitary-adrenal system of the first postnatal period in some laboratory mammals. Endokrinologie37, 301–310.PubMedGoogle Scholar
  19. Nyakas, C. and Endrőczi, E. (1970): Olfaction guided approaching behaviour of infantile rats to the mother in maze box. Acta physiol. Acad. Sci. hung.38, 59–65.PubMedGoogle Scholar
  20. Nyakas, C. and Endrőczi, E. (1972): Passive avoidance learning and memory as a function of age and food deprivation in young rats. Acta physiol. Acad. Sci. hung. (In press.)Google Scholar
  21. Schapibo, S. (1968): Some physiological, biochemical, and behavioral consequences of neonatal hormone administration: Cortisol and thyroxine. Gen. comp. Endocr.10, 214–228.CrossRefGoogle Scholar
  22. Schapiro, S., Geller, E. and Eiduson, S. (1962): Neonatal adrenal cortical response to stress and vasopressin. Proc. Soc. exp. Biol. (N. Y.)109, 937–941.Google Scholar
  23. Wied, D. de (1966): Inhibitory effect of ACTH and related peptides on extinction of conditioned behavior in rats. Proc. Soc. exp. Biol. (N.Y.)122, 28–32.Google Scholar
  24. Wied, D. de (1969): Effect of peptide hormones on behavior. In: Frontiers in Neuroendocrinology. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 97–140.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • Cs. Nyakas
    • 1
  1. 1.Central Research DivisionPostgraduate Medical SchoolBudapestHungary

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