Longitudinal Study of Catecholamine Metabolism in Periodic Catatonia
Biochemical changes accompanying the clinical cycle in periodic catatonia have been studied in this laboratory since 1927. Gjessing first suggested that cyclic variation in thyroid function might be involved in the clinical symptomatology of the illness. Clinical observations of a stuporous patient revealed many signs of adrenal activation. The symptoms during the switch from interval to psychotic phase were similar to those seen after an epinephrine injection. Further extensive studies of phenolic amines and phenolic acids have confirmed the overactivity of the sympathetic nervous system present during the catatonic phase in these cases.
KeywordsUrinary Excretion Phenolic Acid Sympathetic Nervous System Active Phase Urinary Catecholamine
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