The Role of Thyroid and Adrenocortical Hormones in the Biochemical Maturation of the Rat Brain

  • S. Kovács


In the last two decades ample evidence has accumulated to show that hypothyroidism and hyperthyroidism in infancy have serious effects on mammalian neurogenesis (Hamburgh 1969).


Thyroid Hormone Corticosteroid Treatment Average Cell Size Label Thymidine Relative Specific Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Balázs, R., Kovács, S., Cocks, W. A. and Eayrs, J. T. (1967): Effects of neonatal thyroid deficiency on the developing brain. In: 1st International Meeting of the International Society of Neurochemistry, Strasbourg. Abstracts of Communications. p. 12.Google Scholar
  2. Balázs, R., Kovács, S., Teichgräber, P., Cocks, W. A. and Eayrs, J. T. (1968): Biochemical effects of thyroid deficiency on the developing brain. J. Neurochem. 15, 1335–1349.PubMedCrossRefGoogle Scholar
  3. Balázs, R., Cocks, W. A., Eayrs, J. T. and Kovács, S. (1971a): Biochemical effects of thyroid hormones on the developing brain. In: Hormones in Development. Ed. by M. Hamburg and E. J. W. Barrington. Appleton-Century-Crofts, New York. pp. 357–379.Google Scholar
  4. Balázs, R., Kovács, S., Cocks, W. A., Johnson, A. L. and Eayrs, J. T. (1971b): Effect of thyroid hormone on the biochemical maturation of rat brain: postnatal cell formation. Brain Res.25, 555–570.PubMedCrossRefGoogle Scholar
  5. De Guglielmone, A. E. R. and Gómez, C. J. (1966): Influence of neonatal hypothyroidism on amino acids. J. Neurochem.13, 1017–1025.CrossRefGoogle Scholar
  6. Eayrs, J. T. (1954): The vascularity of the cerebral cortex in normal and cretinous rats. J. Anat. (Lond.)88, 164–173.Google Scholar
  7. Eayrs, J. T. (1955): The cerebral cortex of normal and hypothyroid rats. Acta anat. (Basel)25, 160–183.CrossRefGoogle Scholar
  8. Eayrs, J. T. (1961): Age as a factor determining the severity and reversibility of the effects of thyroid deprivation in the rat. J. Endocr.22, 409–419.PubMedCrossRefGoogle Scholar
  9. Eayrs, J. T. (1964): Effect of neonatal hyperthyroidism on maturation and learning in the rat. Anim. Behav.12, 195–199.CrossRefGoogle Scholar
  10. Eayrs, J. T. (1968): Developmental relationship between brain and thyroid. In: Endocrinology and Human Behaviour. Ed. by R. P. Michael. Oxford Univ. Press, London. pp. 239–255.Google Scholar
  11. Eayrs, J. T. and Lishman, W. A. (1955): The maturation of behaviour in hypothyroidism and starvation. Brit. J. Anim. Behav.3, 17–24.CrossRefGoogle Scholar
  12. Eayrs, J. T. and Levine, S. (1963): Influence of thyroidectomy and subsequent replacement therapy upon conditioned avoidance learning in the rat. J. Endocr.25, 505–513.CrossRefGoogle Scholar
  13. Enesco, M. and Leblond, C. P. (1962): Increase in cell number as a factor on the growth of the organs of the young male rat. J. Embryol. exp. Morph.10, 530–562.Google Scholar
  14. Garcia Argiz, C. A., Pasquini, J. M., Kaplun, B. and Gómez, C. J. (1967): Hormonal regulation of brain development. II. Effect of neonatal thyroidectomy on succinate dehydrogenase and other enzymes in developing cerebral cortex and cerebellum of the rat. Brain Res.6, 635–646.PubMedCrossRefGoogle Scholar
  15. Geel, S. E. and Timiras, P. S. (1967): The influence of neonatal hypothyroidism and of thyroxine on the RNA and DNA concentrations of rat cerebral cortex. Brain Res.4, 135–142.PubMedCrossRefGoogle Scholar
  16. Geel, S. E., Valcana, Th. and Timiras, P. S. (1967): Effect of neonatal hypothyroidism and of thyroxine on L-(14C)leucine incorporation in protein in vivo and the relationship to ionic levels in the developing brain. Brain Res.4, 143–150.PubMedCrossRefGoogle Scholar
  17. Hamburgh, M. (1969): The role of thyroid and growth hormones in neurogenesis. In: Current Topics in Developmental Biology. Vol. 4. Ed. by A. A. Moscona and A. Monroy. Academic Press, New York and London. pp. 109–148.Google Scholar
  18. Howard, E. (1965): Effects of corticosterone and food restriction on growth, and on DNA, RNA and cholesterol of the brain and liver in infant mice. J. Neurochem.12, 181–191.PubMedCrossRefGoogle Scholar
  19. Howard, E. (1968): Reductions in size and total DNA of cerebrum and cerebellum in adult mice after corticosterone treatment in infancy. Exp. Neurol.22, 191–208.PubMedCrossRefGoogle Scholar
  20. Kovács, S. (1971): Pajzsmirigy hormon szerepe a hypophysis elülsólebeny postnata-lis fejlődésében (The role of thyroid hormone in the postnatal development of the anterior pituitary). In: Annual Meeting of the Hungarian Physiological Society, Tihany. p. 57.Google Scholar
  21. Kovács, S., Cocks, W. A. and Balázs, R. (1969a): Incorporation of 2-14C thymidine into deoxyribonucleic acid of rat brain during postnatal development; Effect of thyroid hormone. Biochem. J.114, 60.Google Scholar
  22. Kovács, S., Cocks, W. A. and Balázs, R. (1969b): Effect of thyroid hormone administration on the incorporation of 1-14C leucine into protein of rat pituitary and hypothalamus during development. J. Endocr.45, IX–X.PubMedGoogle Scholar
  23. Pasquini, J. M., Kaplun, B., Garcia Argiz, C. A. and Gómez, C. J. (1967): Hormonal regulation of brain development. I. The effect of neonatal thyroidectomy upon nucleic acids, protein and two enzymes in developing cerebral cortex and cerebellum of the rat. Brain Res.6, 621–634.PubMedCrossRefGoogle Scholar
  24. Sawano, S., Arimura, A., Schally, A. V., Redding, T. W. and Sohapiro, S. (1969): Neonatal corticoid administration: effects upon adult pituitary growth hormone and hypothalamic growth hormone-releasing hormone activity. Acta endocr. (Kbh.)61, 57–67.Google Scholar
  25. Schapiro, S. (1968): Some physiological, biochemical and behavioural consequences of neonatal hormone administration: Cortisol and thyroxine. Gen. comp. Endocr.10, 214–228.PubMedCrossRefGoogle Scholar
  26. Vértes, Zs., Lissák, K. and KovÁcs, S. (1971): Üjszülöttkori oestradiol kezelés hatása a hypophysis elülsólebeny és az agy fejlődésére (Effect of neonatal oestradiol treatment on the development of anterior pituitary and brain). In: Annual Meeting of the Hungarian Physiological Society, Tihany. p. 58.Google Scholar
  27. Winick, M. and Noble, A. (1966): Cellular response in rats during malnutrition at various ages. J. Nutr.89, 300–306.PubMedGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • S. Kovács
    • 1
  1. 1.Institute of PhysiologyUniversity Medical SchoolPécsHungary

Personalised recommendations