The Role of the Posterior Pituitary and Its Peptides on the Maintenance of Conditioned Avoidance Behaviour

  • D. de Wied


The pituitary-adrenal axis is the system “par excellence” of homeostasis and responsible for the relative freedom which higher organisms exhibit in a constantly changing environment. Every stressful situation therefore initiates a chain of events which results in the release of ACTH and the subsequent secretion of adrenocortical hormones.


Diabetes Insipidus Avoidance Response Related Peptide Posterior Lobe Extinction Session 
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  1. Agranoff, B. W., Davis, R. E. and Brink, J. J. (1965): Memory fixation in the Goldfish. Proc. nat. Acad. Sci. (Wash.)54, 788.CrossRefGoogle Scholar
  2. Arimura, A., Yanaguchi, T., Yoshimura, K., Imazeki, T. and Itoh, S. (1965): Role of the neurohypophysis in the release of adrenocorticotrophic hormone in the rat. Jap. J. Physiol. 15, 278–295.CrossRefGoogle Scholar
  3. Bohus, B. and Wied, D. de (1966): Inhibitory and facilitatory effect of two related peptides on extinction of avoidance behavior. Science153, 318–320.PubMedCrossRefGoogle Scholar
  4. Davis, R. E. and Agranoff, B. W. (1966): Stages of memory formation in goldfish: evidence for an environmental trigger. Proc. nat. Acad. Sci. (Wash.)55, 555.CrossRefGoogle Scholar
  5. Flexner, J. B. and Flexner, L. B. (1967): Restoration of expression of memory lost after treatment with puromycin. Proc. nat. Acad. Sci. (Wash.) 57, 1651.CrossRefGoogle Scholar
  6. Flexner, L. B. and Flexner, J. B. (1968): Intracerebral saline: effect on memory of trained mice treated with puromycin. Science159, 330.PubMedCrossRefGoogle Scholar
  7. Ginsburg, M. (1968): Production, release, transportation and elimination of the neurohypophyseal hormones. In: Handbook of Experimental Pharmacology. Vol. 23. Ed. by B. Berde. Springer, New York. pp. 286–352.Google Scholar
  8. Glassman, E. (1969): The biochemistry of learning: an evaluation of the role of RNA and protein. Ann. Rev. Biochem. 38, 606.CrossRefGoogle Scholar
  9. Greven, H. M. and Wied, D. de (1967): The active sequence in the ACTH molecule responsible for inhibition of the extinction of conditioned avoidance behavior in rats. Eur op. J. Pharmacol. 2, 14–16.CrossRefGoogle Scholar
  10. Matthies, H., Fähse, C. and Liets, W. (1971): Die Wirkung von RNS -Präcursoren auf die Erhaltung des Langzeitgedächtnisses. Psychopharmacologia (Berl.)20, 10–15.CrossRefGoogle Scholar
  11. McCann, S. M. (1957): ACTH-releasing activity of extract of the posterior lobe of the pituitary in vivo. Endocrinology60, 664.PubMedCrossRefGoogle Scholar
  12. McCatjgh, J. L. (1966): Time-dependent processes in memory storage. Science153, 1351.CrossRefGoogle Scholar
  13. Mirsky, I. A., Stein, M. and Paulish, G. (1954): The secretion of an antidiuretic substance into the circulation of rats exposed to noxious stimuli. Endocrinology54, 491.PubMedCrossRefGoogle Scholar
  14. Murphy, J. V. and Miller, R. E. (1956): Spaced and massed practice with a methodological consideration of avoidance conditioning. J. exp. Psychol. 52, 77–81.PubMedCrossRefGoogle Scholar
  15. Smelik, P. G., Gaarenstroom, J. H., Konojnendijk, W. and Wied, D. de (1962): Evaluation of the role of the posterior lobe of the hypophysis in the reflex secretion of corticotrophin. Acta physiol. pharmacol. neerl. 11, 20–33.PubMedGoogle Scholar
  16. Wied, D. de (1961): The significance of the antidiuretic hormone in the release mechanism of corticotrophin. Endocrinology68, 956–970.PubMedCrossRefGoogle Scholar
  17. Wred, D. de (1965): The influence of the posterior and intermediate lobe of the pituitary and pituitary peptides on the maintenance of a conditioned avoidance response in rats. Int. J. Neuropharmacol. 4, 157–167.CrossRefGoogle Scholar
  18. Wied, D. de (1966): Inhibitory effects of ACTH and related peptides on extinction of conditioned avoidance behavior in rats. Proc. Soc. exp. Biol. (N. Y.)122, 28–32.Google Scholar
  19. Wied, D. de (1969): Effects of peptide hormones on behavior. In: Frontiers in Neuro-endocrinology. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 97–140.Google Scholar
  20. Wied, D. de (1971): Long-term effect of vasopressin on the maintenance of a conditioned avoidance response in rats. Nature (Lond.) (In press).Google Scholar
  21. Wied, D. de and Mirsky, I. A. (1959): The action of hydrocortisone on the antidiuretic and adrenocorticotrophic responses to noxious stimuli. Endocrinology64, 955.CrossRefGoogle Scholar
  22. Wied, D. de and Bohus, B. (1966): Long-term and short-term effects on retention of a conditioned avoidance response in rats by treatment with long-acting Pitressin and α-MSH. Nature (Lond.)212, 1484–1486.CrossRefGoogle Scholar
  23. Wied, D. de, Bouman, P. R. and Smelik, P. G. (1958): The effect of a lipid extract from the posterior hypothalamus and of pitressin on the release of ACTH from the pituitary gland. Endocrinology62, 605.CrossRefGoogle Scholar
  24. Wied, D., Bohus, B., Ernst, A. M., Jong, W. de, Nieuwenhuizen, W., Pieper, E. E. M. and Yasumura, S. (1967): Several aspects of the influence of vasopressin on pituitary-adrenal activity. In: Proceedings of the Royal Society of Medicine, September 1967. Vol. 60. No. 9. 907.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • D. de Wied
    • 1
  1. 1.Rudolf Magnus Institute for Pharmacology Medical FacultyUniversity of UtrechtUtrechtthe Netherlands

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