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Correlated Changes in Gonadotropin Release and Electrical Activity of the Hypothalamus Induced by Electrical Stimulation of the Hippocampus in Immature and Mature Rats

  • M. Kawakami
  • E. Terasawa
  • F. Kimura
  • K. Kubo

Abstract

For the past forty years, attention has been focussed on the limbic structure implicated in gonadal function and sexual behaviour. Klüver and Bucy (1937), Schreiner and Kling (1953) and Green et al. (1957) demonstrated hypersexual behaviour in the monkey and cat with ablations of the pyriform cortex or amygdala, and MacLean (1957a, b) reported intensive grooming and penile erection following the after-discharges induced by electrical stimulation of the hippocampus in the rat, cat and monkey.

Keywords

Electrical Stimulation Precocious Puberty Limbic Structure Hypothalamic Lesion Oestrous Cycle 
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References

  1. Albe-FessARD, D., Statinsky, D. F. and Libouban, S. (1966): Atlas Stéréotaxique du Diencéphale du Bat Blanc. Centre National de la Recherche Scientifique, Paris.Google Scholar
  2. Altman, J. and Das, G. D. (1965): Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. comp. Neurol.124, 319–335.PubMedGoogle Scholar
  3. Andy, O. J. and Stephan, H. (1964): The Septum. Thomas, Springfield.Google Scholar
  4. Andy, O. J. and Koshino, K. (1967): Duration and frequency patterns of the after-discharge from septum and amygdala. Electroenceph. clin. Neurophysiol.22, 167–173.PubMedGoogle Scholar
  5. Andy, O. J., Webster, C. L., Mukawa, J. and Bonn, P. (1962): Electrophysiological comparisons of the dorsal and ventral hippocampus. In: Physiologie de l’Hippocampe. Ed. by Passouant. Centre National de la Recherche Scientifique, Paris. pp. 411–427.Google Scholar
  6. Barraclough, C. A., Yrarrazaval, S. and Hatton, R. (1964): A possible hypothalamic site of action of progesterone in the facilitation of ovulation in the rat. Endocrinology75, 838–845.PubMedGoogle Scholar
  7. Bar-Sela, M. E. and Critchlow, V. (1966): Delayed puberty following electrical stimulation of amygdala in female rats. Amer. J. Physiol.211, 1103–1107.PubMedGoogle Scholar
  8. Bogdanove, E. M. (1957): Selectivity of the effects of hypothalamic lesions on pituitary trophic hormone secretion in the rat. Endocrinology60, 689–697.PubMedGoogle Scholar
  9. Bunn, J. P. and Everett, J. W. (1957): Ovulation in persistent-estrous rats after electrical stimulation of the brain. Proc. Soc. exp. Biol. (N. Y.)96, 369–371.Google Scholar
  10. Campbell, H. J., Fetjer, G. and Harris, G. W. (1964): Effect of intrapituitary infusion of median eminence and other brain extract on anterior pituitary gonado-trophic secretion. J. Physiol. (Lond.)170, 474–486.Google Scholar
  11. Clemens, J. A., Shaar, C. J., Kleber, J. W. and Tandy, W. A. (1971): Areas of the brain stimulatory to LH and FSH secretion. Endocrinology88, 180–184.PubMedGoogle Scholar
  12. Cramer, O. M. and Barraclough, C. A. (1971): Effect of electrical stimulation of the preoptic area on plasma LH concentration in proestrous rats. Endocrinology88, 1175–1183.PubMedGoogle Scholar
  13. D’Angelo, S. A. (1959): Thyroid hormone administration and ovarian and adrenal activity in rats bearing hypothalamic lesions. Endocrinology64, 685–702.PubMedGoogle Scholar
  14. D’Angelo, S. A. and Kravatz, A. S. (1960): Gonadotrophic hormone function in persistent estrous rats with hypothalamic lesions. Proc. Soc. exp. Biol. (N. Y.)104, 130–133.Google Scholar
  15. Davidson, J. M. (1969): Localization of inhibitory feedback by estrogen: Feedback control of gonadotropin secretion. In: Frontiers in Neuroendocrinology. Ed. by W. F. Ganong and L. Martini. Oxford University Press, Oxford, pp. 348–388.Google Scholar
  16. Dey, F. L. (1941): Changes in ovaries and uteri in guinea-pigs with hypothalamic lesions. Amer. J. Anat.69, 61–87.Google Scholar
  17. Dey, F. L. (1943): Evidence of hypothalamic control of hypophysial gonadotrophic function in the female guinea-pig. Endocrinology33, 75–82.Google Scholar
  18. Donovan, B. T. and van der Werfften Bosch, J. J. (1950): Precocious puberty in the rats with hypothalamic lesions. Nature (Lond.)178, 745.Google Scholar
  19. Donovan, B. T. and van der Werff ten Bosch, J. J. (1959): The hypothalamus and sexual maturation in the rat. J. Physiol. (Lond.)147, 78–92.Google Scholar
  20. Donovan, B. T. and van der Werff ten Bosch, J. J. (1965): Physiology of Puberty. Williams and Wilkins, Baltimore.Google Scholar
  21. Dordom, F. and Timiras, P. S. (1952): Inhibitory action of stress on the release of luteinizing hormone by estrogen in the rat. J. Pharmacol. exp. Ther.106, 381–383.Google Scholar
  22. Elwers, M. and Critchlow, V. (1960): Precocious ovarian stimulation following hypothalamic and amygdaloid lesions in rats. Amer. J. Physiol.198, 381–385.PubMedGoogle Scholar
  23. Elwers, M. and Critchlow, V. (1961): Precocious ovarian stimulation following interruption of stria terminalis. Amer. J. Physiol.201, 281–284.PubMedGoogle Scholar
  24. Everett, J. W. (1961): The preoptic region of the brain and its relation to ovulation. In: Control of Ovulation. Ed. by Villee. Pergamon Press, New York. pp. 101–112.Google Scholar
  25. Everett, J. W. (1964): Preoptic stimulative lesions and ovulation in the rat: ‘Thresholds’ and LH-release time in late diestrus and proestrus. In: Major Problems in Neuroendocrinology. Ed. by E. Bajusz and G. Jasmin. Williams and Wilkins, Baltimore. pp. 346–366.Google Scholar
  26. Everett, J. W. and Radford, H. M. (1961): Irritative deposits from stainless steel electrodes in the preoptic rat brain causing release of pituitary gonadotrophin. Proc. Soc. exp. Biol. (N.Y.)108, 604–609.Google Scholar
  27. Everett, J. W. and Quinn, D. L. (1966): Differential hypothalamic mechanisms inciting ovulation and pseudopregnancy in the rat. Endocrinology78, 141–150.PubMedGoogle Scholar
  28. Everett, J. W., Radford, H. M. and Holsinger, J. (1964): Electrolytic irritative lesions in the hypothalamus and other forebrain areas: Effects on luteinizing hormone release and the ovarian cycle. In: Steroid, Biochemistry, Pharmacology and Therapeutics. Ed. by L. Martini. Academic Press, New York. pp. 251–258.Google Scholar
  29. Flerkö, B. (1953): Einfluss experimenteller Hypothalamus-Laesionen auf die Funktion des Sekretionsapparates im weiblichen Genitaltrakt. Acta morph. Acad. Sci. hung.3, 65–86.Google Scholar
  30. Flerkö, B. (1954): Zur hypothalamischen Steuerung der gonadotrophen Funktion der Hypophyse. Acta morph. Acad. Sci. hung.4, 475–492.Google Scholar
  31. Flerkö, B. (1956): Die Rolle hypothalamischer Strukturen bei der Hemmungswirkung des erhöhten Östrogenblutspiegels auf die Gonadotrophinsekretion. Acta physiol. Acad. Sci. hung.9, Suppl. 17–18.Google Scholar
  32. Flerkö, B. (1957): Einfluss experimenteller Hypothalamusläsion auf die durch Folli-kelhormon indirekt hervorgerufene Hemmung der Luteinisation. Endokrinologie34, 202–208.PubMedGoogle Scholar
  33. Flerkö, B. (1963): The central nervous system and the secretion and release of luteinizing hormone and follicle stimulating hormone. In: Advances in Neuroendocrinology. Ed. by S. Nalbandove. University of Illinois Press, Urbana. pp. 211–224.Google Scholar
  34. Flerkó, B. and Bárdos, V. (1959): Zwei verschiedene Effekte experimenteller Läsion des Hypothalamus auf die Gonaden. Acta neuroveg. (Wien)20, 248–262.Google Scholar
  35. Flerkó, B. and Bárdos, V. (1960): Pituitary hypertrophy after anterior hypothalamic lesion. Acta endocr. (Kbh.)35, 375–380.Google Scholar
  36. Flerkó, B. and Bárdos, V. (1961): Absence of compensatory ovarian hypertrophy in rats with anterior hypothalamic lesions. Acta endocr. (Kbh.)36, 180–184.Google Scholar
  37. Gellert, R. J. and Ganong, W. F. (1960): Precocious puberty in rats with hypothalamic lesions. Acta endocr. (Kbh.)33, 569–576.Google Scholar
  38. Gloor, P. (1955a): Electrophysiological studies on the connections of the amygdaloid nucleus in the cat. Part I. The neuronal organization of the amygdaloid projection system. Electroenceph. clin. Neurophysiol.7, 223–242.PubMedGoogle Scholar
  39. Gloor, P. (1955b): Electrophysiological studies on the connection of the amygdaloid nucleus in the cat. Part II. The electrophysiological properties of the amygdaloid projection system. Electroenceph. clin. Neurophysiol.7, 243–264.PubMedGoogle Scholar
  40. Goldman, B. D. and Mahesh, V. B. (1968): Fluctuations in pituitary FSH during the ovulatory cycle in the rat and a possible role of FSH in the induction of ovulation. Endocrinology83, 97–106.PubMedGoogle Scholar
  41. Gorski, R. A. and Barraclough, C. A. (1963): Effect of low dosages of androgen on the differentiation of hypothalamic regulatory control of ovulation in the rat. Endocrinology73, 210–216.PubMedGoogle Scholar
  42. Green, J. D. (1960): The Hippocampus. In: Neurophysiology, Vol. II. Handbook of Physiology. Ed. by J. Field, T. Magoun and M. Hall. American Physiological Society, Washington, D.C. pp. 1373–1390.Google Scholar
  43. Green, J. D., Clemente, C. D. and de Groot, J. (1957): Rhinencephalic lesions and behavior in cats: an analysis of the “Klüver-Bucy” syndrome with particular reference to normal and abnormal sexual behavior. J. comp. Neurol.108, 505–545.PubMedGoogle Scholar
  44. Greer, M. A. (1953): The effect of progesterone on persistent estrus produced by hypothalamic lesion in the rat. Endocrinology53, 380–390.PubMedGoogle Scholar
  45. Halász, B. and Pupp, L. (1965): Hormone secretion of the anterior pituitary gland after physical interruption of all nervous pathways to the hypophysiotrophic area. Endocrinology77, 553–562.PubMedGoogle Scholar
  46. Halász, B. and Gorski, R. A. (1967): Gonadotropinc hormone secretion in female rats after partial or total interruption of neural afferents to the medial basal hypothalamus. Endocrinology80, 608–622.PubMedGoogle Scholar
  47. Halász, B., Pupp, L., Uhlarik, S. and Tima, L. (1965): Further studies on the hormone secretion of the anterior pituitary transplanted into the hypophysiotrophic area of the rat hypothalamus. Endocrinology77, 343–355.PubMedGoogle Scholar
  48. Hillarp, N. A. (1949): Studies on the localization of hypothalamic center controlling the gonadotropic function of the hypophysis. Acta endocr. (Kbh.)2, 11–23.Google Scholar
  49. Hohlweg, W. and Junkmann, K. (1932): Die hormonal-nervöse Regulierung der Funktion des Hypophysenvorderlappens. Klin. Wschr.11, 321–323.Google Scholar
  50. Jacobson, S. (1963): Sequence of myelinization in the brain of the albino rat. J. comp. Neurol.121, 5–29.PubMedGoogle Scholar
  51. Kalra, S. P. and McCann, S. M. (1971): Changes in gonadotropin releasing factor content in the rat hypothalamus following electrochemical stimulation of the anterior hypothalamic area (AHA) and during estrous cycle. In: Program of the 53rd Meeting of the Endocrine Society. No. 58, San Francisco.Google Scholar
  52. Kalra, S. P., Ajika, K., Krulich, L., Fawcett, C. P., Quijada, M. and McCann, S. M. (1971): Effects of hypothalamic and preoptic electrochemical stimulation on gonadotropin and prolactin release in proestrus rats. Endocrinology88, 1150–1158.PubMedGoogle Scholar
  53. Kawakami, M. and Terasawa, E. (1967): Differential control of sex hormone and oxytocin upon evoked potentials in the hypothalamus and midbrain reticular formation. Jap. J. Physiol.17, 65–93.Google Scholar
  54. Kawakami, M. and Saito, H. (1967): Unit activity in the hypothalamus of the cat: Effect of genital stimuli, luteinizing hormone and oxytocin. Jap. J. Physiol.17, 466–486.Google Scholar
  55. Kawakami, M. and Terasawa, E. (1970): Effect of electrical stimulation of the brain on ovulation during estrous cycle in the rats. Endocr. jap.17, 7–13.PubMedGoogle Scholar
  56. Kawakami, M. and Kubo, K. (1971): Neuro-correlate of limbic-hypothalamo-pituitary gonadal axis in the rat: Change in limbic-hypothalamic unit activity induced by vaginal and electrical stimulation. N euro endocrinology7, 65–89.Google Scholar
  57. Kawakami, M., Seto, K. and Yoshida, K. (1966a): Influence of the limbic system on ovulation and on progesterone and estrogen formation in rabbit’s ovary. Jap. J. Physiol.16, 254–273.Google Scholar
  58. Kawakami, M., Terasawa, E., Tsuchihashi, S. and Yamanaka, K. (1966b): Differential control by sex hormones of brain activity in the rabbit and its physiological significance. In: Steroid Dynamics. Ed. by G. Pincus, E. Nakao and L A. Tait. Academic Press, New York and London, pp. 237–302.Google Scholar
  59. Kawakami, M., Seto, K., Terasawa, E. and Yoshida, K. (1967): Mechanisms in the limbic system controlling reproductive functions of the ovary with special reference to the positive feedback of progestin to the hippocampus. Progress in Brain Research. Vol. 27. 69–102.PubMedGoogle Scholar
  60. Kawakami, M., Kimura, F. and Ishida, S. (1968): Effect of the bilateral lesions of the fornix on the vaginal cycle in rats. Folia endocr. Jap.43, 154.Google Scholar
  61. Kawakami, M., Terasawa, E. and Ibuki, T. (1970a): Changes in multiple unit activity of the brain during the estrous cycle. N euroendocrinology6, 30–48.Google Scholar
  62. Kawakami, M., Terasawa, E., Ibuki, T. and Manaka, M. (1970b): Effects of sex hormones and ovulation-blocking steroids and drugs on electrical activity of the rat brain. In: Santa Ynez Inn Steroid Conference, Los Angeles 1970. (In press).Google Scholar
  63. Kawakami, M., Seto, K., Kimura, F. and Yanase, M. (1971a): Brain mechanisms involved with adaptation to the immobilization stress. In: Gunma Symposia on Endocrinology. Vol. 8. (In press).Google Scholar
  64. Kawakami, M., Seto, K., Kimura, F. and Yanase, M. (1971b): Difference in the buffer action between the limbic structures and the hypothalamus to the immobilization stress in rabbits. In: Progress in Brain Research. Ed. by D. H. Ford. Karger, Basel/New York. (In press.)Google Scholar
  65. Kawakami, M., Tebasawa, E., Seto, K. and Wakabayashi, K. (1971c): Effect of electrical stimulation of the medial preoptic area on hypothalamic multiple unit activity in relation to LH release. Endocr. jap. (In press.)Google Scholar
  66. Kimura, F. and Kawakami, M. (1968): Effect of the hippocampal stimulation on the vaginal cycle in rats. Folia endocr. jap.43, 1059.Google Scholar
  67. Klüver, H. and Bucy, P. C. (1937): Psychic blindness and other symptoms following bilateral temporal lobotomy on rhesus monkeys. Amer. J. Physiol.119, 352–353.Google Scholar
  68. Koikegami, H. (1964): Amygdala and other related limbic structures: experimental studies on the anatomy and function. Acta med. biol. (Niigato)12, 73–266.Google Scholar
  69. Koikegami, H., Yamada, T. and Usui, K. (1954): Stimulation of the amygdaloid nuclei and periamygdaloid cortex with special reference to its effects on uterine movements and ovulation. Folia psychiat. neurol. jap.8, 7–31.PubMedGoogle Scholar
  70. Koikegami, H., Fuse, S. and Kawakami, K. (1960): Bilateral destruction experiments of hippocampus or amygdaloid nuclear region. Neurol. Medico-Chirurg.2, 49–55.Google Scholar
  71. Köves, K. and Halász, B. (1970): Location of the neural structures triggering ovulation in the rat. Neuroendocrinology6, 180–193.PubMedGoogle Scholar
  72. Lawton, I. E. and Sawyer, C. H. (1970): Role of amygdala in regulating LH secretion in the adult female rat. Amer. J. Physiol.218, 622–626.PubMedGoogle Scholar
  73. Leonard, C. M. and Scott, J. W. (1971): Origin and distribution of the amygdalo-fugal pathways in the rat. An experimental neuroanatomical study. J. comp. Neurol.141, 313–330.PubMedGoogle Scholar
  74. Lissák, K. and Endrőczi, E. (1961): Neurohumoral factors in the control of animal behavior. In: Brain Mechanisms and Learning. Ed. by J. F. Delagresnaye. Black-well Scientific Publications, Oxford, pp. 293–398.Google Scholar
  75. Lissák, K. and Endrőczi, E. (1962): Some aspects of the effect of hippocampal stimulation on the endocrine system. In: Physiologie de l’Hippocampe. Ed. by Passouant. Centre National de la Recherche Scientifique, Paris, pp. 463–471.Google Scholar
  76. Machida, T. (1970): Luteinization of ovarian transplants in gonadectomized male and female rats under stressful conditions and its relation to sexual differentiation of the hypothalamus. Endocr. jap.17, 189–193.PubMedGoogle Scholar
  77. MacLean, P. D. (1957a): Chemical and electrical stimulation of hippocampus in unrestrained animals. Part I: Method and electroencephalographic findings. Arch. Neurol. Psychiat. (Chic.)78, 113–127.Google Scholar
  78. MacLean, P. D. (1957b): Chemical and electrical stimulation of hippocampus in unrestrained animals. Part II: Behavioral findings. Arch. Neurol. Psychiat. (Chic.)78, 128–142.Google Scholar
  79. McCann, S. M. (1962): Hypothalamic luteinizing hormone-releasing factor. Amer. J. Physiol.202, 395–400.Google Scholar
  80. McCann, S. M., Watanabe, S., Crighton, D. B., Beddow, D. and Dhariwal, A. P. S. (1968): The physiology and biochemistry of luteinizing hormone-releasing factor and follicle stimulating hormone-releasing factor. In: International Symposium on the Pharmacology of Hormonal Polypeptides. Ed. by N. Back, L. Martini and R. Paoletti. Plenum Press, New York.Google Scholar
  81. Neill, J. D. (1970): Effect of “Stress” on serum prolactin and luteinizing hormone levels during the estrus cycle of the rat. Endocrinology87, 1192–1197.PubMedGoogle Scholar
  82. Nlkitovitch-Winer, M. B. (1962): Induction of ovulation in rats by direct intra-pituitary infusion of median eminence extracts. Endocrinology64, 914–920.Google Scholar
  83. NISWENDER, G. D., Midgley, A. R. Jr., Monroe, S. C. and Reichert, L. E. Jr. (1968): Radioimmunoassay for rat luteinizing hormone with antiovine LH serum and ovine LH-131L Proc. Soc. exp. Biol. (N. Y.)128, 807–811.Google Scholar
  84. Ramaley, J. A. and Gorski, R. A. (1967): The effect of hypothalamic deafferentation upon puberty in the female rat. Acta endocr. (Kbh.)56, 661–674.Google Scholar
  85. Ramirez, V. D. and Sawyer, C. H. (1965): Advancement of puberty in the female rat by estrogen. Endocrinology76, 1158–1168.PubMedGoogle Scholar
  86. Redmond, W. C. (1968): Ovulatory response to brain stimulation or exogenous luteinizing hormone in progesterone-treated rat. Endocrinology83, 1013–1022.PubMedGoogle Scholar
  87. Riss, W. (1958): Effect of limbic damage in infancy on subsequent endocrine development and running activity in rats. Anat. Rec.130, 364.Google Scholar
  88. Riss, W., Btjrstein, S. D. and Johnson, R. W. (1963): Hippocampal or pyriform lobe damage in infancy and endocrine development of rats. Amer. J. Physiol.204, 861–866.PubMedGoogle Scholar
  89. Rodrigues, J. A. (1959): Influence de l’écorce cérébrale sur le cycle sexuel du rat blanc. C.R. Soc. Biol. (Paris)153, 1271–1273.Google Scholar
  90. Sawyer, C. H. (1970): Electrophysiological correlates of release of pituitary ovulating hormones. Fed. Proc.29, 1895–1899.PubMedGoogle Scholar
  91. Schiavi, R. C. (1964): Effect of anterior and posterior hypothalamic lesions on precocious sexual maturation. Amer. J. Physiol.206, 805–810.PubMedGoogle Scholar
  92. Schreiner, L. and Kling, A. (1953): Behavioral changes following rhinencephalic injury in cat. J. Neurophysiol.16, 643–659.PubMedGoogle Scholar
  93. Sherwood, N. and Timiras, P. S. (1968): Stereotaxic Atlas of the Developing Rat Brain. University of California Press, Berkeley, Calif.Google Scholar
  94. Stumpf, W. C. (1968): Estradiol-concentrating neurons: Topography in the hypothalamus by dry-mount autoradiography. Science162, 1001–1003.PubMedGoogle Scholar
  95. Szentágothai, J., Flerkó, B., Mess, B. and Halasz, B. (1968): Hypothalamic Control of the Anterior Pituitary. Akadémiai Kiadó, Budapest.Google Scholar
  96. Takasugi, N. (1956): Untersuchungen über die hypophysäre gonadotrope Aktivität der daueroestrischen und normalen Ratten unter Stress-Situationen. J. Fac. Sci. Univ. Tokyo. Sec. IV, 7, 605–623.Google Scholar
  97. Talwalker, P. K., Ratner, A. and Meites, J. (1963): In vivo inhibition of pituitary prolactin synthesis and release by hypothalamic extract. Amer. J. Physiol.205, 213–218.PubMedGoogle Scholar
  98. Tejasen, T. and Everett, J. W. (1967): Surgical analysis of the preoptic-tuberal pathway controlling ovulatory release of gonadotropins in the rat. Endocrinology81, 1387–1396.PubMedGoogle Scholar
  99. Terasawa, E. and Timiras, P. S. (1968): Electrical activity during the estrous cycle of the rat: cyclic changes in limbic structures. Endocrinology83, 207–216.PubMedGoogle Scholar
  100. Terasawa, E. and Sawyer, C. H. (1969a): Electrical and electrochemical stimulation of the hypothalamus-adenohypophyseal system with stainless steel electrode. Endocrinology84, 918–925.PubMedGoogle Scholar
  101. Terasawa, E. and Sawyer, C. H. (1969b): Changes in electrical activity in the rat hypothalamus related to electrochemical stimulation of adenohypophyseal function. Endocrinology85, 143–149.PubMedGoogle Scholar
  102. Terasawa, E. and Sawyer, C. H. (1970): Diurnal variation in the effects of progesterone on multiple unit activity in the rat hypothalamus. Exp. Neurol.27, 359–374.PubMedGoogle Scholar
  103. Timiras, P. S., Vernadakis, A. and Sherwood, N. M. (1968): Development and plasticity of the nervous system. In: Biology of Gestation. Ed. by N. S. Assali. Academic Press, New York. pp. 261–319.Google Scholar
  104. Velasco, M. E. and Taleisnik, S. (1969): Effect of hippocampal stimulation on the release of gonadotropin. Endocrinology85, 1154–1159.PubMedGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • M. Kawakami
    • 1
  • E. Terasawa
    • 1
  • F. Kimura
    • 1
  • K. Kubo
    • 1
  1. 1.2nd Department of PhysiologyYokohama City University School of MedicineYokohamaJapan

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