Facilitatory and Inhibitory Mesencephalic Influence on Gonadotropin Release

  • S. Taleisnik
  • H. F. Carrer


It is well known that the maintenance of a basic level of gonadotropin secretion by the anterior pituitary depends on its connection with the hypothalamus. This neural structure contains neurons which elaborate chemical agents that regulate pituitary hormone secretion after reaching the gland by the portal vessels. Although the hypothalamus is recognized to have autonomic activity and is capable of maintaining a tonic release of gonadotropin even when disconnected from the rest of the brain (Halász and Gorski 1967), a number of stimuli can affect its activity. The most clear evidence in this respect is provided by coitus in the so-called reflex ovulators. Many other internal as well as external stimuli of different modalities are known to exert a modulating influence on the endocrine function. These signals, of diverse origin, reach the hypothalamic neurons by different routes being the neural information transformed into a chemical one before influencing the anterior pituitary. The pool of hypothalamic neurons which secrete the releasing and inhibitory factors thus form the final common pathway for the pituitary gland.


Luteinizing Hormone Ventral Tegmental Area Superior Colliculus Ovulatory Response Preoptic Area 
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  1. Anden, N.-E., Dahlström, A., Fuxe, K., Larsson, K., Olson, L. and Ungerstedt, U. (1966): Acta physiol. scand.67, 313.CrossRefGoogle Scholar
  2. Ban, T. (1964): Med. J. Osaka Univ.15, 1.PubMedGoogle Scholar
  3. Benedetti, W. L., Appeltauer, L. C., Reissenweber, N. S., Dominguez, R., Griño, R. and Sas, J. (1965): Acta physiol. lot.-amer.15, 218.Google Scholar
  4. Beyer, C., Tindal, J. J. and Sawyer, C. H. (1962): Exp. Neurol.6, 435.PubMedCrossRefGoogle Scholar
  5. Brooks, C. McC., Ushiyama, J. and Lange, G. (1962): Amer. J. Physiol.202, 487.PubMedGoogle Scholar
  6. Bunn, J. P. and Everett, J. W. (1957): Proc. Soc. exp. Biol. (N. Y.)96, 369.Google Scholar
  7. Carrer, H. F. and Taleisnik, S. (1970): J. Endocr.48, 527.PubMedCrossRefGoogle Scholar
  8. Critchlow, V. (1958): Endocrinology63, 596.PubMedCrossRefGoogle Scholar
  9. Dafny, N. and Feldman, S. (1969): Electroenceph. clin. Neurophysiol.26, 578.PubMedCrossRefGoogle Scholar
  10. Dahlström, A. and Ftjxe, K. (1964): Acta physiol. scand. 62, Suppl. 232. Google Scholar
  11. Eccleston, D., Padjen, A. and Randic, M. (1968): J. Physiol. (Lond.)201, 228.Google Scholar
  12. Endrőczi, E., Babichev, V., Hartmann, G. and Korányi, L. (1968): Endocr. Exp.2, 1.Google Scholar
  13. Everett, J. W. and Radford, H. M. (1961): Prcc. Soc. exp. Biol. (N. Y.)108, 604.Google Scholar
  14. Fortier, C. (1966): In: The Anterior Pituitary Gland. Vol. 2. Ed. by G. W. Harris and B. T. Donovan. Univ. of California Press, Los Angeles, p. 195.Google Scholar
  15. Green, J. D. and Adey, W. R. (1956): Electroenceph. clin. Neurophysiol.8, 245.PubMedCrossRefGoogle Scholar
  16. Guillery, R. W. (1957): J. Anat. (Lond.)91, 91.Google Scholar
  17. Gumulka, W., Samanin, R., Garattini, S. and Valzelli, L. (1969): J. Pharmacol.8, 830.Google Scholar
  18. Halász, B. and Gorski, R. A. (1967): Endocrinology80, 608.PubMedCrossRefGoogle Scholar
  19. Heller, A. and Moore, R. Y. (1965): J. Pharmacol. exp. Ther.150, 1.PubMedGoogle Scholar
  20. Kawakami, M. and Sawyer, C. H. (1959): Endocrinology65, 625.Google Scholar
  21. Koikegami, H., Yamada, T. and Usui, K. (1954): Folia psychiat. neurol. jap.8, 7.PubMedGoogle Scholar
  22. Machne, X. and Segundo, J. P. (1956): J. Neurophysiol.19, 232.PubMedGoogle Scholar
  23. Mangili, G., Motta, M. and Martini, L. (1966): In: Neuroendocrinology. Vol. 1. Ed. by L. Martini and W. F. Ganong. Academic Press, Los Angeles. p. 297.Google Scholar
  24. Nauta, W. J. H. (1958): Brain81, 319.PubMedCrossRefGoogle Scholar
  25. Pekary, A. E., Davidson, J. M. and Zondek, B. (1967): Endocrinology80, 365.PubMedCrossRefGoogle Scholar
  26. Shealy, C. W. and Peele, T. L. (1957): J. Neurophysiol.20, 125.PubMedGoogle Scholar
  27. Stein, L. and Wise, C. D. (1969): J. comp, physiol. Psychol.67, 189.CrossRefGoogle Scholar
  28. Taleisnik, S., Velasco, M. E. and Astrada, J. J. (1970): J. Endocr.46, 1.PubMedCrossRefGoogle Scholar
  29. Taleisnik, S., Caligaris, L. and Astrada, J. J. (1971): In: Proceedings of the IIIrd International Congress on Hormonal Steroids. Excerpta Medica. (In press).Google Scholar
  30. Tsubokawa, T. and Sutin, J. (1963): Electroenceph. clin. Neurophysiol.15, 804.PubMedCrossRefGoogle Scholar
  31. Velasco, M. E. and Taleisnik, S. (1969a): Endocrinology84, 132.PubMedCrossRefGoogle Scholar
  32. Velasco, M. E. and Taleisnik, S. (1969b): Endocrinology85, 1154.PubMedCrossRefGoogle Scholar
  33. Velasco, M. E. and Taleisnik, S. (1972): J. Endocr. (In press).Google Scholar
  34. Wooley, D. E. and Timiras, P. S. (1962): Endocrinology70, 196.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • S. Taleisnik
    • 1
  • H. F. Carrer
    • 1
  1. 1.Instituto de Investigación MédicaMercedes y Martín FerreyraCórdobaArgentina

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