Accumulation of 3H-Lysine in Limbic and Brainstem Structures

  • D. H. Ford
  • R. K. Rhines


The current literature is filled with numerous references concerning the effect of stimulation or lesion placement in limbic or brainstem regions on the function of the neuroendocrine system. Both anatomical and physiological evidence (Colvin et al. 1968, Hayward 1970, Innes and Michal 1970, Kawakami et al. 1968, Mietkiewski and Miskowiak 1969, Komisaruk et al. 1967, Shimada and Gorbman 1970, Terasawa and Timiras 1968, Martini 1969) suggest a functional interrelationship between these two components of the CNS which in turn may influence the hypothalamic release of factors regulating the anterior pituitary gland. With our interests in protein synthesis in the CNS (Ford 1967, Ford and Rhines 1969a, b, Ford and Rhines 1970a, b), particularly in relation to accumulation of amino acids in different types of neurons, we thought it would be of interest to compare amino acid accumulations in neurons and brain regions associated with limbic, neurosecretory and brainstem areas as compared to other regions of the CNS.


Premotor Cortex Preoptic Area Ventral Horn Supraoptic Nucleus Label Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Colvin, G. B., Whitmoyer, D. I., Lisk, R. D., Walter, D. O. and Sawyer, C. H. (1968): Changes in sleep-wakefulness in female rats during circadian and estrous cycles. Brain Res.7, 173–181.PubMedCrossRefGoogle Scholar
  2. Ford, D. H. (1967): Changes in brain accumulation of amino acids and adenine associated with changes in the physiologic state. In: Progress in Brain Research, vol. 29. Ed. by A. Lajtha and D. H. Ford. Elsevier, Amsterdam.Google Scholar
  3. Ford, D. H. and Cohan, G. (1968): Changes in weight and volume of rat spinal cord motor neurons with increasing age. Acta anat. (Basel)71, 311 – 319.CrossRefGoogle Scholar
  4. Ford, D. H. and Rhines, R. K. (1969a): (3H) Lysine accumulation in motoneurons in rats of different age compared with the accumulation in other tissues. Acta neurol. scand.45, 41 – 52.PubMedCrossRefGoogle Scholar
  5. Ford, D. H. and Rhines, R. K. (1969b): 3H-lysine accumulation in spinal cord grey matter and ventral horn motoneurons in the rat as related to age and neuronal cytoplasmic volume. Acta neurol. scand.45, 529 – 539.PubMedCrossRefGoogle Scholar
  6. Ford, D. H. and Rhines, R. K. (1970a): Accumulation of (3H) lysine in various types of neurons in male rats. J. Neurol. Sci.10, 179 – 183.PubMedCrossRefGoogle Scholar
  7. Ford, D. H. and Rhines, R. K. (1970b): Accumulation of 14C by ventral horn and dorsal root ganglion neurons after intravenous injection of (14C)GABA. J. Neurol, Sci.10, 331 – 337.CrossRefGoogle Scholar
  8. Hayward, J. N. (1970): Central neural regulation of antidiuretic hormone release and unit activity in the supraoptic nucleus of the behaving rhesus monkey. Amer. J. Anat.129, 203–206.PubMedCrossRefGoogle Scholar
  9. Innes, D. I. and Michal, E. K. (1970): Effects of progesterone and oestrogen on the electrical activity of the limbic system. J. exp. Zool.175, 487 – 492.PubMedCrossRefGoogle Scholar
  10. Kawakami, M., Seto, K. and Yoshida, K. (1968): Influences of the limbic structure on biosynthesis of ovarian steroids in rabbits. Jap. J. Physiol.18, 356 – 372.CrossRefGoogle Scholar
  11. Komisaruk, B. R., McDonald, P. G.Whitmoyer, D. I. and Sawyer, C. H. (1967): Effects of progesterone and sensory stimulation on EEG and neuronal activity in the rat. Exp. Neurol.19, 494–507.PubMedCrossRefGoogle Scholar
  12. Martini, L. (1969): Action of hormones on the central nervous system. Gen. comp. Endocr. Suppl. 2, 214–226.CrossRefGoogle Scholar
  13. Mietkiewski, K.and Miskowiak, B. (1969): Histologic and histochemical changes induced by cyproterone (antiandrogen) in the supraoptic nucleus of the hypothalamus in rats. Folia Morphol. (Warszawa)28, 316 – 325.Google Scholar
  14. Shimada, H. and Gorbman, A. (1970): Long lasting changes in RNA synthesis in the forebrains of female rats treated with testosterone soon after birth. Biochem. biophys. Res. Commun.38, 423 – 430.PubMedCrossRefGoogle Scholar
  15. Terasawa, E. and Timiras, P. S. (1968): Electrical activity during the estrous cycle of the rat: cyclic changes in limbic structures. Endocrinology83, 207 – 216.PubMedCrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • D. H. Ford
    • 1
  • R. K. Rhines
    • 1
  1. 1.Department of Anatomy Downstate Medical CenterState University of New YorkBrooklynUSA

Personalised recommendations