A Comparison of Chlorpromazine-Induced Extrapyramidal Syndrome in Male and Female Rats

  • J. F. Mislow
  • A. J. Friedhoff


One of the most intriguing observations on the effects of drugs used for the treatment of psychotic disorders is the relationship between the therapeutic effects of these drugs and their ability to produce parkinsonian-like extrapyramidal syndrome in man. It has been pointed out (Friedhoff 1969) that all effective antipsychotic drugs have the potential for producing a parkinsonian-like reaction in man. Effective drugs of divergent chemical structure which are used for the treatment of psychoses such as the phenothiazines, butyrophenones, and the rauwolfia alkaloids all have this potential. Within a given class, drugs which do not readily produce extrapyramidal disturbance are also ineffective antipsychotic agents. Among the phenothiazines, e.g., phenergan is one such drug with a low extrapyramidal disturbing potential. But again this compound is not an effective antipsychotic agent. Although not all patients receiving antipsychotic drugs develop clinical manifestations of Parkinsonism, it has been shown (Alpert 1967) through the use of a sensitive device for measuring resting finger tremor, that patients receiving effective doses of these drugs all have subclinical manifestations of extrapyramidal disturbance.


Estrous Cycle Intact Female Castrate Male Phenothiazine Derivative Blue Spruce Farm 
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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • J. F. Mislow
    • 1
  • A. J. Friedhoff
    • 1
  1. 1.Department of Psychiatry and Neurology School of MedicineNew York University Medical CenterNew YorkUSA

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