The Role of Brain Monoamines in the Susceptibility to Seizures Brought about by Chemical and Electrical Stimulations

  • A. K. Pfeifer
  • G. Unyi


It is well known that the brain monoamines depleting agents such as reserpine and tetrabenazine beside their tranquillizing effect increase the susceptibility to seizures induced by pentetrazol and by electrical stimulation. Both actions of the drugs are considered to be in connection with the low norepinephrine (NE), dopamine (DA) and serotonin (5-HT) content of the brain. Both the tranquillizing and convulsion facilitating effects can be reversed by monoamine oxidase inhibitors, which elevate the content of all three monoamines in the brain.


Brain Monoamine Amphetamine Derivative Methyl Analogue Brain Amine Convulsion Threshold 
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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • A. K. Pfeifer
    • 1
  • G. Unyi
    • 1
  1. 1.Institute of Experimental MedicineHungarian Academy of SciencesBudapestHungary

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