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Effect of Dehydrobenzperidol on Pituitary Adrenal Function

  • L. Debreczeni

Abstract

The effect of butyrophenones on central nervous processes is known from the pioneer study of Janssen et al. (1963) and the mechanism of their action was analysed by a number of investigators. Observations, both experimental and empirical, indicate that the most potent butyrophenone, dehydrobenzperidol or droperidol support the adaptation of the organism to noxious stimuli.

Keywords

Electric Shock Plasma Cortisol Concentration ACTH Release Adrenocortical Response ACTH Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L., Verbrtjggen, F. J. and Van Ntjeten, J. M. (1963): The pharmacology of dehydrobenzperidol, a new potent and short acting neuroleptic agent chemically related to haloperidol. Drug Res. (Arzneimittel-Forsch.13, 205–211.Google Scholar
  2. Mattingly, D. (1962): A simple fluorometric method for the estimation of free 11-hydroxycorticoids in human plasma. J. clin. Path.15, 374–379.PubMedCrossRefGoogle Scholar
  3. Van der Vies, J., Bakker, R. F. M. and De Wied, D. (1960): Correlated studies on plasma-free corticosterone and on and renal steroid formation in vitro. ActaEndocr. (Kbh.)34, 513–523.Google Scholar
  4. Van Gogh, J. J., De Wied, D. and Schönbaum, E. (1963): Adrenocorticotropic activity in the rat assessed by in vivo and in vitro indices. Amer, J. Physiol.205, 1083–1088.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • L. Debreczeni
    • 1
  1. 1.Mohács HospitalMohácsHungary

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