The Role of Pineal Principles in the Control of ACTH Secretion

  • F. Piva
  • O. Schiaffini
  • M. Motta
  • L. Martini


In order to clarify whether the pineal gland and its principles play a role in the regulation of the hypothalamic-pituitary-adrenal axis several indole derivatives synthetized in the gland (melatonin, 5-hydroxytryptophol, 5-methoxytryptophol, etc.) have been injected directly into the cerebrospinal fluid of normal rats, through a cannula chronically implanted into one of the lateral ventricles of the brain. The effects of such principles on the plasma levels of corticosterone have been evaluated. The intracerebral way of administration has been selected because previous studies had indicated that the endocrine effects of pineal principles are mediated by specific receptors present in the central nervous system (Martini 1969, Fraschini and Martini 1970). Moreover, it has been repeatedly reported that indole and methoxyindole derivatives do not cross easily the blood brain barrier following systemic administrations (Wurtman et al. 1968).


Versus Versus Versus Pineal Gland Plasma Corticosterone ACTH Secretion Corticosterone Concentration 
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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • F. Piva
    • 1
  • O. Schiaffini
    • 1
    • 2
  • M. Motta
    • 1
  • L. Martini
    • 1
  1. 1.Department of PharmacologyUniversity of MilanMilanItaly
  2. 2.Department of NeurobiologyMedical SchoolBuenos AiresArgentina

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