The Role of Pineal Principles in the Control of ACTH Secretion

  • F. Piva
  • O. Schiaffini
  • M. Motta
  • L. Martini


In order to clarify whether the pineal gland and its principles play a role in the regulation of the hypothalamic-pituitary-adrenal axis several indole derivatives synthetized in the gland (melatonin, 5-hydroxytryptophol, 5-methoxytryptophol, etc.) have been injected directly into the cerebrospinal fluid of normal rats, through a cannula chronically implanted into one of the lateral ventricles of the brain. The effects of such principles on the plasma levels of corticosterone have been evaluated. The intracerebral way of administration has been selected because previous studies had indicated that the endocrine effects of pineal principles are mediated by specific receptors present in the central nervous system (Martini 1969, Fraschini and Martini 1970). Moreover, it has been repeatedly reported that indole and methoxyindole derivatives do not cross easily the blood brain barrier following systemic administrations (Wurtman et al. 1968).


Versus Versus Versus Pineal Gland Plasma Corticosterone ACTH Secretion Corticosterone Concentration 


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  1. Bhattacharya, A. N. and Marks, B. H. (1969): Effects of pargyline and amphetamine upon acute stress responses in rats. Proc. Soc. exp. Biol. (N. Y.) 130, 1194–1198.Google Scholar
  2. Oarr, L. A. and Moore, K. E. (1968): Effects of reserpine and alpha-methyltyrosine on brain catecholamines and the pituitary-adrenal response. Neuroendocrinology3, 285–302.CrossRefGoogle Scholar
  3. Critchlow, V., Liebelt, R. A., Bar-Sela, M., Mountcastle, W. and Lipscomb, H. S. (1963): Sex difference in resting pituitary-adrenal function in the rat. Amer. J. Physiol.205, 807–815.PubMedGoogle Scholar
  4. David-Nelson, M. A. and Brodish, A. (1969): Evidence for a diurnal rhythm of corticotrophin-releasing factor (CRF) in the hypothalamus. Endocrinology85, 861–866.PubMedCrossRefGoogle Scholar
  5. Fraschini, F. and Martini, L. (1970): Rhythmic phenomena and pineal principles. In: The Hypothalamus. Ed. by L. Martini, M. Motta and F. Fraschini. Academic Press, New York. pp. 529–549.Google Scholar
  6. Fraschini, F., Mangili, G., Motta, M. and Martini, L. (1964): Midbrain and feedback control of adrenocorticotrophin secretion. Endocrinology75, 765–769.PubMedCrossRefGoogle Scholar
  7. Giuliani, G., Motta, M. and Martini, L. (1966): Reserpine and corticotrophin secretion. Acta endocr. (Kbh.) 51, 203–209.Google Scholar
  8. Guillemin, R., Clayton, G. W., Lipscomb, H. S. and Smith, J. D. (1959): Fluoro-metric measurement of rat plasma and adrenal corticosterone concentration. J. Lab. clin. Med.53, 830–832.PubMedGoogle Scholar
  9. Klein, D. C. and Weller, J. L. (1970): Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Science169, 1093–1094.PubMedCrossRefGoogle Scholar
  10. Mangili, G., Motta, M., Muciaccia, W. and Martini, L. (1965): Midbrain stress and ACTH secretion. Europ. Bev. Endocr.1, 247–253.Google Scholar
  11. Mangili, G., Motta, M. and Martini, L. (1966): Control of adrenocorticotropic hormone secretion. Tn: Neuroendocrhwlogy. Vol. I. Ed. by L. Martini and W. F. Ganong. Academic Press, New York. pp. 297–370.Google Scholar
  12. Martini, L. (1969): Action of hormones on the central nervous system. Gen. comp. Endocr. Suppl. 2, 214–226.CrossRefGoogle Scholar
  13. Retiene, K. (1970): Control of circadian periodicities in pituitary function. In: The Hypothalamus. Ed. by L. Martini, M. Motta and F. Fraschini. Academic Press, New York. pp. 551–568.Google Scholar
  14. Retiene, K., Zimmerman, E., Schindler, W. J., Neuenschwander, J. and Lipscomb, H. S. (1968): A correlative study of endocrine rhythms in rats. Acta endocrin. (Kbh.) 57, 615–622.Google Scholar
  15. Sheridan, M. N., Reiter, R. J. and Jacobs, J. J. (1969): An interesting anatomical relationship between the hamster pineal gland and the ventricular system of the brain. J. Endocr.45, 131–132.PubMedCrossRefGoogle Scholar
  16. Van Loon, G. R., Scapagnini, U., Cohen, R. and Ganong, W. F. (1971): Effect of intraventricular administration of adrenergic drugs on the adrenal venous 17-hydroxycorticosteroid response to surgical stress in the dog. Neuroendocrinology8, 257–272.PubMedCrossRefGoogle Scholar
  17. Van Peenen, P. F. D. and Way, E. L. (1957): The effect of certain central nervous system depressants on pituitary-adrenal activating agents. J. Pharmacol, exp. Ther.120, 261–267.Google Scholar
  18. Wurtman, R. J. (1970): The role of brain and pineal indoles in neuroendocrine mechanisms. In: The Hypothalamus. Ed. by L. Martini, M. Motta and F. Fraschini. Academic Press, New York. pp. 153–165.Google Scholar
  19. Wurtman, R. J., Axelrod, J. and Kelly, D. E. (1968): The Pineal. Academic Press, New York.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • F. Piva
    • 1
  • O. Schiaffini
    • 1
    • 2
  • M. Motta
    • 1
  • L. Martini
    • 1
  1. 1.Department of PharmacologyUniversity of MilanMilanItaly
  2. 2.Department of NeurobiologyMedical SchoolBuenos AiresArgentina

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