Mechanisms Controlling Pituitary Gonadotropin Secretion in Prepuberal Rats

  • F. Fraschini
  • R. Collu
  • E. E. Müller


In the last few years considerable evidence has accumulated indicating that the secretion of pituitary gonadotropins in adult animals is regulated by multiple mechanisms. The existence of an inhibitory control exerted by the pineal gland and by its principles is now generally admitted (Fraschini 1969, Reiter and Fraschini 1969, Fraschini and Martini 1970); on the other hand, it has been shown that brain catecholamines may exert a tonic stimulatory effect on the secretion of these hormones (Barraclough and Sawyer 1957, 1959, Coppola et al. 1965, Schneider and McCann 1969, Kamberi et al. 1970). The aim of the studies here to be reported was to investigate whether these two mechanisms are active also in prepuberal rats.


Luteinizing Hormone Follicle Stimulate Hormone Pineal Gland Gonadotrophin Secretion Uterine Weight 
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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • F. Fraschini
    • 1
  • R. Collu
    • 1
  • E. E. Müller
    • 1
  1. 1.Department of PharmacologyUniversity of MilanMilanItaly

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