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Effect of Synthetic TSH-Releasing Factor (TRF) and of Some TRF Analogues on Pituitary Function

  • H. Steiner
  • F. Piva
  • M. Motta
  • G. Gavazzi
  • R. Collu
  • L. Martini

Abstract

Synthetic TSH-releasing factor (TRF) is by definition not contaminated with other releasing factors and acts quite specifically on its target cells, i.e. on anterior pituitary thyrotrophs. It seems, however, reasonable to make the assumption that the endocrine system, taken as a whole, may be affected in one way or another, when a very potent endocrinologically active substance like TRF modifies its equilibrium. The dynamics of TSH secretion (release and synthesis) under the influence of TRF have been recently studied in detail in our laboratory; experiments have now been performed in order to evaluate the possible actions of TRF on the pituitary-adrenocortical axis. A number of synthetic TRF analogues have also been included in this study. Their utilization proved very useful in elucidating the mode of action of TRF on both the pituitary-thyroid and the pituitary-adrenal axis.

Keywords

Corticosterone Level Plasma Corticosterone Plasma Corticosterone Level Serum Corticosterone Level Intracarotid Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • H. Steiner
    • 1
    • 2
  • F. Piva
    • 1
  • M. Motta
    • 1
  • G. Gavazzi
    • 1
  • R. Collu
    • 1
  • L. Martini
    • 1
  1. 1.Department of PharmacologyUniversity of MilanMilanItaly
  2. 2.Department of Experimental MedicineF. Hoffmann-La Roche Co. Ltd.BasleSwitzerland

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