The Effect of Oestradiol on Pituitary-Adrenal Function in Intact and Thyroidectomized Rats

  • F. Tallián


Interactions between the pituitary-adrenal and pituitary-gonadal functions as well as between those and the pituitary-thyroid axis were the subjects of many studies in recent decades. Both synergistic and antagonistic influences have been observed in animal experiments which suggested an extremely complicated regulatory process behind these events (Velardo 1957, D’Angelo and Hughes 1963, Fortier et al. 1970, etc.). Concerning the effect of oestradiol on the pituitary-adrenal axis, it is known that oestradiol administration led to the enlargement of adrenals, on the one hand, but depending on the dosages, it may enhance or inhibit the adrenal steroidogenesis under both in vivo and in vitro conditions, on the other hand (Kitay 1963, Amesbury et al. 1965, etc.).


ACTH Secretion Compensatory Hypertrophy Adrenal Steroidogenesis Pituitary ACTH Oestradiol Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. D’Angelo, S. A. (1963): Central nervous regulation of the secretion and release of thyroid stimulating hormone. In: Advances in Neuroendocrinology. Vol. 3. Ed. by Nalbandov, A. N. Univ. Illinois Press, Urbana, pp. 158–210.Google Scholar
  2. Fortier, C, Labrie, F., Pelletier, G., Raynaud, J. P., Ducommun, P., Delgado, A., Labrie, R. and Ho-kim, M. A. (1970): Recent studies on the feed-back control of ACTH secretion, with particular reference to the role of transcortin in pituitary -thyroid-adrenocortical interrelations. In: Ciba Found. Symp. on Control Processes in Multicellular Organisms. Ed. by Wolstenholme, G. E. and Knight, J. Churchill, London. pp. 178–196.Google Scholar
  3. Gemzell, C. A. (1952): Increase in the formation and secretion of ACTH in rats following administration of oestradiol-monobenzoate. Acta endocr. (Kbh.)11, 221–228Google Scholar
  4. Kitay, J. I. (1963): Effects of testosterone on pituitary corticotrophine and adrenal steroid secretion in male and female rats. Acta endocr. (Kbh.)43, 601–608.Google Scholar
  5. Lissák, K. and Endröczi, E. (1965): Involvement of the limbic structures in conditioning, motivation and recent memory. In: Symposium on Structure and Function of Limbic System. Hakone, Japan.Google Scholar
  6. Smith, E. R., Johnson, J., Weick, R. F., Levine, S. and Davidson, J. M. (1971): Inhibition of the reproductive system in immature rats by intracerebral implantation of Cortisol. Neuroendocrinology, 8, 94–106.PubMedCrossRefGoogle Scholar
  7. Telegdy, Gy., Schreiber, G. and Endröczi, E. (1964): Effect of oestrogens implanted into the hypothalamus on the activity of the pituitary-adrenocortical system. Acta physiol. Acad. Sci. hung.25, 229–234.PubMedGoogle Scholar
  8. Velardo, I. T. (1957): Steroidal aspects of pregnane inhibition of progesterone in decidual development. Amer. J. Physiol.188, 317–320.PubMedGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • F. Tallián
    • 1
  1. 1.Department of Gynaecology and ObstetricsPostgraduate Medical SchoolBudapestHungary

Personalised recommendations