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Influence of Synthetic TRF Administration and Hypothalamic Stimulation Upon the Ultrastructure of Thyrotrophs

  • Y. Shiotani
  • M. Sakagami
  • K. Fujimoto
  • T. Ban

Abstract

It is well known that secretory activity of the anterior pituitary gland is regulated by the hypothalamus through the humoral mediator called releasing factor (RF) or inhibiting factor (IF). In this decade, many studies have been done to purify RF or IF, and Bowers et al. (1970) reported recently that porcine thyrotropin releasing factor (TRF) is (Pyro/Glu-Hiw-Pro/NH2). However, precise site of RF production or storage in the hypothalamus is still obscure. In our laboratory, electron microscopic studies have been done on the anterior pituitary cells of rabbits, which were stimulated electrically in the hypothalamus, in order to clarify the nervous control of RF or IF discharge from the hypothalamus into the anterior pituitary gland (Shiotani et al. 1969).

Keywords

Golgi Apparatus Secretory Granule Anterior Pituitary Gland Hypothalamic Nucleus Anterior Pituitary Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ban, T. (1964): The hypothalamus, especially on its fiber connections, and the septopreoptico-hypothalamic system. Med. J. Osaka Univ.15, 1–83.PubMedGoogle Scholar
  2. Bowers, C. Y., Schaxly, A. V., Enzmann, P., Bøler, J. and Folkers, K. (1970): Porcine thyrotropin releasing hormone is (Pyro)Glu-His-Pro(NH2). Endocrinology86, 1143–1153.PubMedCrossRefGoogle Scholar
  3. Kurotsu, T. (1953): Our experimental method for studies on hypothalamus. Med. J. Osaka Univ.4, 171–174.Google Scholar
  4. Shiotani, Y., Sakagami, M., Fujimoto, K. and Ban, T. (1969): Ultrastructural changes in the anterior pituitary gland induced by electrical stimulation of the hypothalamus. Endocr. jap. Suppl. 1, 1–9.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • Y. Shiotani
    • 1
  • M. Sakagami
    • 1
  • K. Fujimoto
    • 1
  • T. Ban
    • 1
  1. 1.Department of AnatomyOsaka University Medical SchoolOsakaJapan

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