Influence of Synthetic TRF Administration and Hypothalamic Stimulation Upon the Ultrastructure of Thyrotrophs
It is well known that secretory activity of the anterior pituitary gland is regulated by the hypothalamus through the humoral mediator called releasing factor (RF) or inhibiting factor (IF). In this decade, many studies have been done to purify RF or IF, and Bowers et al. (1970) reported recently that porcine thyrotropin releasing factor (TRF) is (Pyro/Glu-Hiw-Pro/NH2). However, precise site of RF production or storage in the hypothalamus is still obscure. In our laboratory, electron microscopic studies have been done on the anterior pituitary cells of rabbits, which were stimulated electrically in the hypothalamus, in order to clarify the nervous control of RF or IF discharge from the hypothalamus into the anterior pituitary gland (Shiotani et al. 1969).
KeywordsGolgi Apparatus Secretory Granule Anterior Pituitary Gland Hypothalamic Nucleus Anterior Pituitary Cell
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