Advertisement

Thyroxine Binding to Anterior Pituitary Proteins in Vitro: Correlation with Anterior Pituitary Growth

  • V. Schreiber

Abstract

The main role in the regulation of anterior pituitary function is played by the hypothalamic hypophysiotrophic factors or hormones (Guillemin 1964, 1967, Schally et al. 1968, McCann et al. 1968, McCann and Porter 1969, Harris and George 1969, Schreiber 1969, Campbell 1970, Meites 1970). Most of the available evidence shows that the primary effect of these factors is the release of anterior pituitary hormones into the blood, i.e., their secretion, and not their increased synthesis. The whole question is still awaiting a final answer and it will probably not be long before it is demonstrated that the hypothalamic hypophysiotrophic hormones directly influence biosynthesis of the anterior pituitary hormones, as preliminary evidence already exists (Geschwind 1970).

Keywords

Thyroid Hormone Anterior Pituitary Simultaneous Treatment Cyproterone Acetate Anterior Pituitary Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Campbell, H. J. (1970): Control of anterior pituitary gland by hypothalamic releasing factors. Sci. Basis Med. Ann. Rev.152. Google Scholar
  2. Ducommun, S. and Gtjillemin, R. (1966): Maintenance of normal morphology in adenohypophysial transplants by topical administration of hypothalamic extract with a simple method for transplantation in a pneumoderma pouch. Proc. Soc. exp. Biol. (N.Y.)122, 1251.Google Scholar
  3. Duncan, D. B. (1955): Multiple range and multiple F tests. Biometrics11, 1.CrossRefGoogle Scholar
  4. Eisenfeld, A. J. (1970): 3H-oestradiol: in vitro binding to macromolecules from the rat hypothalamus, anterior pituitary and uterus. Endocrinology86, 1313.CrossRefGoogle Scholar
  5. Eisenfeld, A. J. and Axelrod, J. (1966): Selectivity of estrogen distribution in tissues. J. Pharmacol. exp. Ther.150, 469.Google Scholar
  6. Emmens, C. W. and Miller, B. G. (1969): Estrogens, proestrogens and antiestrogens. Steroids13, 725.PubMedCrossRefGoogle Scholar
  7. Evans, J. S. and Nikitovitch-Winer, M. B. (1969): Functional reactivation and cytological restoration of pituitary grafts by continuous local intravenous infusion of median eminence extracts. N euroendocrinology4, 83.Google Scholar
  8. Farquhar, M. G. and Fürth, J. (1959): Electron microscopy of experimental pituitary tumors. Amer. J. Path.35, 698.Google Scholar
  9. Flament-Durand, J. (1965): Observations on pituitary transplants into the hypothalamus of the rat. Endocrinology77, 446.PubMedCrossRefGoogle Scholar
  10. Florsheim, W. H. (1969): Hypothalamic influences on pituitary thyrotrophic function. In: Physiology and Pathology of Adaptation Mechanisms. Ed. by E. Bajusz. Pergamon Press, Oxford.Google Scholar
  11. Ford, D. H. and Gross, J. (1958): The metabolism of 131I-labelled thyroid hormones in the hypophysis and brain of the rabbit. Endocrinology62, 416.PubMedCrossRefGoogle Scholar
  12. Ford, D. H., Kantounis, S. and Lawrence, R. (1959): The localization of 131I-labelled triiodothyronine in the pituitary and brain of normal and thyroidectomized male rats. Endocrinology64, 977.PubMedCrossRefGoogle Scholar
  13. Ford, D. H., Fishman, S. K. and Rhines, R. (1962): The uptake of 131I-labelled L-triiodothyronine by the brain, pituitary and muscle of diestrous and estrous female rats as compared with the uptake in male rats. Gen. comp. Endocr.2, 480.PubMedCrossRefGoogle Scholar
  14. Geschwind, I. I. (1970): Mechanism of action of hypothalamic adenohypophysio-tropic factors. In: Hypophysiotropic Hormones of the Hypothalamus: Assay and Chemistry. Ed. by J. Meites. Williams and Wilkins Co., Baltimore.Google Scholar
  15. Grinberg, R. (1964): Effect of epinephrine on metabolism of thyroxine by pituitary and brain. Proc. Soc. exp. Biol. (N.Y.)116, 35.Google Scholar
  16. Grinberg, R. (1965): Binding of thyroxine and triiodothyronine by heart and pituitary proteins. Nature (Lond.)205, 701.CrossRefGoogle Scholar
  17. Guillemin, R. (1964): Hypothalamic factors releasing pituitary hormones. Recent Progr. Hormone Res.20, 89.PubMedGoogle Scholar
  18. Guillemin, R. (1967): The adenohypophysis and its hypothalamic control. Ann. Rev. Physiol.29, 313.CrossRefGoogle Scholar
  19. Halász, B., Pupp, L. and Uhlarik, S. (1962): Hypophysiotrophic area in the hypothalamus. J. Endocr.25, 147.PubMedCrossRefGoogle Scholar
  20. Halász, B., Pupp, L., Uhlarik, S. and Tima, L. (1965): Further studies on the hormone secretion of the anterior pituitary transplanted into the hypophysiotrophic area of the rat hypothalamus. Endocrinology77, 343.PubMedCrossRefGoogle Scholar
  21. Haour, P. and Selye, H. (1948): Inhibition des effets morphogènes produits par les folliculoïdes sur l’hypophyse du rat. Ann. Endocr. (Paris)9, 154.Google Scholar
  22. Harris, G. W. and George, R. (1969): Neurohormonal control of the adenohypophysis and the regulation of the secretion of TSH, ACTH and growth hormone. In: The Hypothalamus. Ed. by W. Haymaker, E. Anderson and W. J. H. Nauta. C. C. Thomas, Springfield, Ill.Google Scholar
  23. Jensen, E. V. and Jacobsohn, H. I. (1962): Basic guides to the mechanism of estrogen action. Recent Progr. Hormone Res.18, 387.Google Scholar
  24. Kato, J. and Villee, C. A. (1967): Factors affecting uptake of estradiol-6,7-3H by the hypophysis and hypothalamus. Endocrinology80, 1133.PubMedCrossRefGoogle Scholar
  25. Lisk, R. D. (1969): Oestrogen: direct effects on hypothalamus or pituitary in relation to pituitary weight changes. Neuroendocrinology4, 368.PubMedCrossRefGoogle Scholar
  26. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951): Protein measurement with the Folin phenol reagent. J. biol. Chem.193, 265.PubMedGoogle Scholar
  27. Matsuzaki, S. (1968): Difference in effects of thyroidectomy and thyroxine supplements on hepatic and anterior pituitary enzymes in the rat. Endocr. jap.15, 223.PubMedCrossRefGoogle Scholar
  28. McCann, S. M. and Porter, J. C. (1969): Hypothalamic-pituitary stimulating and inhibiting hormones. Physiol. Rev.49, 240.PubMedGoogle Scholar
  29. McCann, S. M., Dhariwal, A. P. S. and Porter, J. C. (1968): Regulation of the adenohypophysis. Ann. Rev. Physiol.30, 589.CrossRefGoogle Scholar
  30. Meites, J. (Ed.) (1970): Hypophysiotropic Hormones of the Hypothalamus: Assay and Chemistry. Williams and Wilkins, Baltimore.Google Scholar
  31. Nikitovitch-Winer, M. B. and Evans, J. S. (1964): Reactivation of hypophysial grafts by continued perfusion with median eminence extracts. In: Proceedings of 2nd International Congress of Endocrinology. Excerpta Medica, Amsterdam. p. 1278.Google Scholar
  32. Oberling, C., Guérin, M., Sèze, L. de and Lacour (1950): Production de tumeurs hypophysares et mammaires chez le rat par injection de folliculine seule où associée à d’autres hormones. Bull. Ass. franç. Cancer37, 176.PubMedGoogle Scholar
  33. Palka, Y. S., Ramirez, V. D. and Sawyer, C. H. (1966): Distribution and biological effects of tritiated estradiol implanted in the hypothalamo-hypophysial region of female rats. Endocrinology78, 487.PubMedCrossRefGoogle Scholar
  34. Přibyl, T., Schreiber, V. and Roháčová, J. (1971): Binding of thyroxine by rat tissue proteins. Physiol. bohemoslov.20.Google Scholar
  35. Přibyl, T., Schreiber, V. and Roháčová, J. (1972): Further characteristic of the binding of thyroxine by adenohypophysial proteins in vitro. (In press.)Google Scholar
  36. Purves, H. D. (1963): Discussion. In: Thyrotropin. Ed. by S. C. Werner. Thomas, Springfield, Ill. p. 73.Google Scholar
  37. Robbins, J. and Rall, J. E. (1960): Protein associated with thyroid hormones. Physiol. Rev.40, 415.PubMedGoogle Scholar
  38. Schally, A. V., Arimura, A., Bowers, C. Y., Kastin, A. J., Sawano, S. and Redding, T. W. (1968): Hypothalamic neurohormones regulating anterior pituitary function. Recent Progr. Hormone Res.24, 497.PubMedGoogle Scholar
  39. Schreiber, V. (1967): Functions of the adenohypophysis: special position of thyrotrophs function. Acta Univ. Carol. Med. (Praha)13, 493.Google Scholar
  40. Schreiber, V. (1969): Chemistry of hypothalamic releasing factors. Excerpta Medica International Congress Series 184, 555.Google Scholar
  41. Schreiber, V., Přibyl, T. and Roháčová, J. (1970a): Adenohypophysial growth afte” oestrogens in rats: binding of 125I-thyroxine by adenohypophysial proteins. Physiol. bohemoslov.19, 501.PubMedGoogle Scholar
  42. Schreiber, V., Přibyl, T. and Roháčová, J. (1970b): Hypertrofie adenohypofysy po estrogenech: vazba 125I-thyroxinu na adenohypofysární proteiny. Čs. Fysiol.19, 275.Google Scholar
  43. Schreiber, V., Přibyl, T. and Roháčová, J. (1970c): Sex hormones and adeno-hypophysial weight: interaction of gonadectomy, oestradiol and testosterone in rats. Physiol. bohemoslov.19, 511.PubMedGoogle Scholar
  44. Schreiber, V., Přibyl, T. and Roháčová, J. (1971a): Hypertrofie adenohypofysy u krys po estrogenili interakce s testosterone. Sborn. lék.73, 49.PubMedGoogle Scholar
  45. Schreiber, V., Přibyl, T. and Roháčová, J. (1971b): Effect of the anti-androgen cyproterone acetate on the action of oestrogen on the rat endocrine system. Physiol. bohemoslov.20, 255 – 261.PubMedGoogle Scholar
  46. Schreiber, V., Přibyl, T. and Roháčová, J. (1971c): Vergleich der Wirkung der Antiandrogene Cyproteron und Cyproteron Acetat auf das endokrine System der Ratten. Endokrinologie. (In press.)Google Scholar
  47. Schreiber, V., Přibyl, T. and Roháčová, J. (1971d): Adenohypophysial weight and thyroxine binding by adenohypophysial proteins in vitro: interaction of oestradiol with gestagens, hydrocortisone and testosterone. Physiol. bohemoslov. (In press.)Google Scholar
  48. Schreiber, V., Přibyl, T. and Roháčová, J. (1972): Der Einfluß des Anti-Oestro-gens Clomiphen auf die adenohypophysäre Reaktion auf Oestradiol. Endokrinologie. (In press.)Google Scholar
  49. Selye, H., Collip, J. B. and Thomson, D. L. (1935): Effect of oestrin on ovaries and adrenals. Proc. Soc. exp. Biol. (N.Y.)32, 1377.Google Scholar
  50. Tata, J. R. (1958): A cellular thyroxine-binding protein fraction. Biochim. biophys. Acta (Amst.)28, 91.CrossRefGoogle Scholar
  51. Tonoue, T. and Yamamoto, K. (1967): Effect of thyroidectomy and a thyroxine supplement on amino acid incorporation into proteins of rat anterior pituitary. Endocrinology81, 1029.PubMedCrossRefGoogle Scholar
  52. Trevorrov, V. (1939): Studies on the nature of the iodine in blood. J. biol. Chem.127, 737.Google Scholar
  53. Zbuzková-Kmentová, V. and Schreiber, V. (1966): Empêchement par les hormones thyroïdiennes de l’hypertrophie hypophysaire causée par l’oestrogène. C.R. Acad. Sci. (Paris)262, 1565.Google Scholar
  54. Zbuzková-Kmentová, V. and Schreiber, V. (1967): Gonado-thyroidal relationships: interactions of oestrogens and thyroid hormones in infantile rats. Endocr. Exp.1, 29.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • V. Schreiber
    • 1
  1. 1.Laboratory for Endocrinology and Metabolism IIIrd Medical Clinic Faculty of General MedicineCharles UniversityPragueCzechoslovakia

Personalised recommendations