On the Location of the Neural Structures Involved in the Reserpine-Induced Hypersecretion of ACTH

  • B. Halász
  • I. Lengvári


It is well known that reserpine causes an increase in pituitary ACTH secretion. A single injection of the drug results in a marked decrease of hypothalamic CRF (corticotrophic releasing factor, Bhattacharya and Marks 1969) and pituitary ACTH content (Kitay et al. 1959, Saffran and Vogt 1960, Maickel et al. 1961, Bhattacharya and Marks 1969) and a simultaneous elevation in plasma corticosterone levels (Maickel et al. 1961, Bhattacharya and Marks 1969). Administration of reserpine for several days leads to adrenal hypertrophy (Gaunt et al. 1954, Hertting and Hornykiewicz 1957, Montanari and Stockham 1962).


Optic Chiasma Plasma Corticosterone Level Medial Basal Hypothalamus Pituitary ACTH Adrenal Hypertrophy 
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  1. Bhattacharya, A. N. and Marks, B. H. (1969): Reserpine- and chlorpromazine-induced changes in hypothalamo-hypophyseal-adrenal system in rats in the presence and absence of hypothermia. J. Pharmacol. exp. Ther.165, 108–116.PubMedGoogle Scholar
  2. Flament-Durand, J. (1965): Observations on pituitary transplants into the hypothalamus of the rat. Endocrinology77, 446–454.PubMedCrossRefGoogle Scholar
  3. Gaunt, R., Renzi, A. A., Antonchak, N., Miller, G. J. and Gilman, M. (1954): Endocrine aspects of the pharmacology of reserpine. Ann. N. Y. Acad. Sci.59, 22–35.PubMedCrossRefGoogle Scholar
  4. Guillemin, R., Clayton, G. W., Smith, J. D. and Lipscomb, H. S. (1958): Measurement of free corticosteroids in rat plasma. Physiological validation of a method. Endocrinology63, 349–358.PubMedCrossRefGoogle Scholar
  5. Halász, B. and Gorski, R. A. (1967): Gonadotrophic hormone secretion in female rats after partial or total interruption of neural afferents to the medial basal hypothalamus. Endocrinology80, 608–622.PubMedCrossRefGoogle Scholar
  6. Halász, B. and Pupp, L. (1965): Hormone secretion of the anterior pituitary gland after physical interruption of all nervous pathways to the hypophysiotrophic area. Endocrinology77, 553–562.PubMedCrossRefGoogle Scholar
  7. Halász, B., Pupp, L. and Uhlarik, S. (1962): Hypophysiotrophic area in the hypothalamus. J. Endocr.25, 147–154.PubMedCrossRefGoogle Scholar
  8. Halász, B., Pupp, L., Uhlarik, S. and Tima, L. (1965): Further studies on the hormone secretion of the anterior pituitary transplanted into the hypophysiotrophic area of the rat hypothalamus. Endocrinology77, 343–355.PubMedCrossRefGoogle Scholar
  9. Hertting, G. and Hornykiewicz, O. (1957): Beeinflussung der durch Reserpin hervorgerufenen Nebennierenrinde Hypertrophie durch Cortison. Acta endocr. (Kbh.)26, 204–208.Google Scholar
  10. Kitay, J. L., Holub, D. A. and Jailer, J. W. (1959): “Inhibition” of pituitary ACTH release after administration of reserpine and epinephrine. Endocrinology65, 548–554.PubMedCrossRefGoogle Scholar
  11. Maickel, R. F., Westermann, E. O. and Brodle, B. B. (1961): Effects of reserpine and cold-exposure on pituitarv-adrenocortical function in rats. J. Pharmacol. exp. Ther.134, 167–175.PubMedGoogle Scholar
  12. Montanari, R. and Stockham, M. A. (1962): Effects of single and repeated doses of reserpine on the secretion of adrenocorticotrophic hormone. Brit. J. Pharmacol.18, 337–345.PubMedGoogle Scholar
  13. Nauta, W. (1956): An experimental study of the fornix system in the rat. J. comp. Neurol.104, 247–270.PubMedCrossRefGoogle Scholar
  14. Raisman, G. (1970): An evaluation of the basic pattern of connections between the limbic system and the hypothalamus. Amer. J. Anat.129, 197–202.PubMedCrossRefGoogle Scholar
  15. Saffran, M. and Vogt, M. (1960): Depletion of pituitary corticotrophin by reserpine and by nitrogen mustard. Brit. J. Pharmacol.15, 165–169.PubMedGoogle Scholar
  16. Silber, R. H., Busch, R. D. and Oslapas, R. (1958): Practical procedure for estimation of corticosterone or hydrocortisone. Clin. Chem.4, 278–285.PubMedGoogle Scholar
  17. Smelik, P. G. (1967): ACTH secretion after depletion of hypothalamic monoamines by reserpine implants. Neuroendocrinology2, 247–254.CrossRefGoogle Scholar
  18. Szentágothai, J. (1968): Anatomical considerations. In: Hypothalamic Gontrol of the Anterior Pituitary. An Experimental-Morphological Study. Ed. by J. Szentágothai, B. Flerkó, B. Mess and B. Halász. Akadémiai Kiadó, Budapest, pp. 22–109.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 1973

Authors and Affiliations

  • B. Halász
    • 1
  • I. Lengvári
    • 1
  1. 1.Department of AnatomyUniversity Medical SchoolPécsHungary

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