Transfer RNAs as Objects of Structural Research
The primary structure of the nucleic acids is the basis on which all other properties of these biopolymers depend. That is why determination of the nucleotide sequence in nucleic-acid molecules is receiving such great attention at the present time. This problem can be solved only if certain conditions are satisfied, for otherwise it would be useless even to make the attempt. The first condition is homogeneity of the test material. In fact, structure can be determined only if it is absolutely certain that the test object is a chemically individual compound. Next, the specimen must be available in adequate quantitites for analysis. Finally, the size of the molecule is important, because the macromolecular nature of most nucleic acids has until recently gravely hindered their study by existing methods.
KeywordsPrimary Structure Structural Research Yeast tRNAA1 Transfer RNAs Activate Amino Acid
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