Reflections on the Etiology of Benign Prostatic Hypertrophy

  • John T. Grayhack


So-called benign prostatic hypertrophy is a fibromuscular glandular hyperplasia of the prostate that occurs in the prostate of the human male as he ages. Although other aging animals such as the dog exhibit a diffuse hyperplasia of the prostate, the characteristic nodular hypertrophy of man is unique. Histological studies indicate that benign prostatic hypertrophy usually begins in the inner or suburethral prostatic glands. Either stromal or epithelial changes may initiate or predominate in this process(1,2). Although atrophic changes in the peripheral prostatic glands may accompany the proliferation of the periurethral elements, weight(3) and volume(4) studies indicate that the overall size of the prostate of man increases with aging. Histological evidence of benign prostatic hypertrophy is present in most, not all, men over 60 years of age(5).


Lateral Lobe Benign Prostatic Hypertrophy Cyproterone Acetate Prostatic Growth Testosterone Propionate 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • John T. Grayhack
    • 1
  1. 1.Department of UrologyNorthwestern University Medical SchoolEvanstonUSA

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