The most common product of the catabolism of nucleic acids is uric acid. Among its precursors are the purine nucleosides adenosine and guanosine present in deoxyribonucleic acid (DNA) and in ribonucleic acid (RNA). The general outline of the metabolic pathway is illustrated in Fig. 1. The importance of uric acid in a number of neoplastic and non-neoplastic disease states is well known. Our primary concern has been the identification of other nucleic acid metabolites that appear in human urine. Study of their origin, metabolic vicissitudes, and biological significance has been a major activity in our laboratory.
KeywordsUric Acid Human Urine Ribonucleic Acid Surgical Stress Roswell Park Memorial Institute
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- 3.Sanger, F., Brownlee, G., and Barrell, B. G. Proceedings of the Fourth Meeting, Federations of European Biochemical Societies. Oslo, July 1967.Google Scholar
- 6.Dunn, D. B., and Hall, R. In Handbook of Chemistry, Sober, H. A. (ed.), The Chemical Rubber Co., Cleveland, Ohio, p. G-3, 1968.Google Scholar
- 7.Starr, J. L., and Sello, B. H. Phys. Rev. 49: 623, 1969.Google Scholar
- 10.Chheda, G. B. Life Sci. 8:979, Part I I, 1969.Google Scholar
- 11.Schoonees, R., Mittelman, A., Chheda, G. B., and Murphy, G. P. J. Surg. Oncol. (in press).Google Scholar
- 12.Mittelman, A., Chheda, G. B., and Grace, J. T., Jr. J. Surg. Res. (in press).Google Scholar
- 13.Tritsch, G. L., Chheda, G. B., and Mittelman, A. Unpublished data.Google Scholar