The Nucleosides of Human Urine

  • Arnold Mittelman


The most common product of the catabolism of nucleic acids is uric acid. Among its precursors are the purine nucleosides adenosine and guanosine present in deoxyribonucleic acid (DNA) and in ribonucleic acid (RNA). The general outline of the metabolic pathway is illustrated in Fig. 1. The importance of uric acid in a number of neoplastic and non-neoplastic disease states is well known. Our primary concern has been the identification of other nucleic acid metabolites that appear in human urine. Study of their origin, metabolic vicissitudes, and biological significance has been a major activity in our laboratory.


Uric Acid Human Urine Ribonucleic Acid Surgical Stress Roswell Park Memorial Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Brown, G. M., and Attardi, G. Biochem. Biophys. Res. Commun. 20: 298, 1965.PubMedCrossRefGoogle Scholar
  2. 2.
    Tamaoki, T., and Lane, G. B. Biochemistry 7: 3431, 1968.PubMedCrossRefGoogle Scholar
  3. 3.
    Sanger, F., Brownlee, G., and Barrell, B. G. Proceedings of the Fourth Meeting, Federations of European Biochemical Societies. Oslo, July 1967.Google Scholar
  4. 4.
    Borek, E., and Srinivasan, P. R. Ann. Rev. Biochem. 35: 275, 1966.CrossRefGoogle Scholar
  5. 5.
    Zachau, H. G. Angew. Chem. 8: 645, 1969.CrossRefGoogle Scholar
  6. 6.
    Dunn, D. B., and Hall, R. In Handbook of Chemistry, Sober, H. A. (ed.), The Chemical Rubber Co., Cleveland, Ohio, p. G-3, 1968.Google Scholar
  7. 7.
    Starr, J. L., and Sello, B. H. Phys. Rev. 49: 623, 1969.Google Scholar
  8. 8.
    Schweizer, M. P., Chheda, G. B., Hall, R. H., Baczynskyj, L., and Biemann, K. Biochemistry 8: 3283, 1969.PubMedCrossRefGoogle Scholar
  9. 9.
    Chheda, G. B., Hall, R. H., Magrath, D. L., Mozejko, J., Schweizer, M. P., Stasiuk, L., and Taylor, P. R. Biochemistry 8: 3278, 1969.PubMedCrossRefGoogle Scholar
  10. 10.
    Chheda, G. B. Life Sci. 8:979, Part I I, 1969.Google Scholar
  11. 11.
    Schoonees, R., Mittelman, A., Chheda, G. B., and Murphy, G. P. J. Surg. Oncol. (in press).Google Scholar
  12. 12.
    Mittelman, A., Chheda, G. B., and Grace, J. T., Jr. J. Surg. Res. (in press).Google Scholar
  13. 13.
    Tritsch, G. L., Chheda, G. B., and Mittelman, A. Unpublished data.Google Scholar
  14. 14.
    Dyson, W. H., Chen, C. M., Alam, S. H., Hall, R. H., Hong, C. I., and Chheda, G. B. Science 170: 328, 1970.PubMedCrossRefGoogle Scholar
  15. 15.
    Fittler, F., and Hall, R. H. Biochem. Biophys. Res. Commun. 25: 441, 1966.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Arnold Mittelman

There are no affiliations available

Personalised recommendations