Renal Metabolism in Obstructive Uropathy

  • Horst K. A. Schirmer


Many of our present concepts in obstructive uropathy are based on Hinman’s observations with respect to hydronephrotic atrophy subsequent to complete obstruction of the flow of urine and the existence of a renal counterbalance where an anatomical and functional readjustment between the less injured or uninjured portion and the more injured portion in terms of performance takes place(1). Together with Hepler, he introduced the concept of ischemia as possible cause for a hastening of dilatation and atrophy of the kidney with obstructed urine flow(2).


Anaerobic Glycolysis Ureteral Obstruction Obstructive Uropathy Tissue Respiration Silk Ligature 
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  1. 1.
    Hinman, F. The Principles and Practice of Urology, W. B. Saunders Co., Philadelphia and London, pp. 487–527, 1935.Google Scholar
  2. 2.
    Hinman, F., and Hepler, A. Experimental hydronephrosis. The effect of ligature of one branch of the renal artery on its rate of development. Arch. Surg. 12: 830, 1926.CrossRefGoogle Scholar
  3. 3.
    Schirmer, H. K. A. Renal metabolism in experimental hydronephrosis. Invest. Urol. 2: 598, 1965.PubMedGoogle Scholar
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    Schirmer, H. K. A., Murphy, G. P., Taft, J. L., and Scott, W. W. Renal metabolism with proximal or distal ureteral occlusion. Surg. Gvnec. Obstet. 123: 539–543, 1966.Google Scholar
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    Schirmer, H. K. A., and Marshall, R. E. Metabolism of atrophic renal tissue following removal of complete ureteral obstruction. J. Urol. 100: 596, 1968.PubMedGoogle Scholar
  6. 6.
    Umbreit, W. W., Burris, R. H., and Stauffer, T. F. Manometric Techniques, Burgess Publishing Co., Minneapolis, p. 28, 1957.Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Horst K. A. Schirmer
    • 1
  1. 1.The James Buchanan Brady Urological InstituteThe Johns Hopkins HospitalBaltimoreUSA

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