Technology of Induction of Cancer in Rat with Pulse-Doses of Homogenized Hydrocarbons

  • Charles B. Huggins


The research began with the work of a thoughful and colorful surgeon, Percivall Pott (1713–1788), and his investigation(1) of cancer of the scrotum: “there is a disease as peculiar to a certain set of people, which has not, at least to my knowledge, been publicly noticed; I mean the chimney-sweeper’s cancer. It is a disease which always makes its first attack on, and its first appearance in, the inferior part of the scrotum; where it produces a superficial, painful, ragged, ill-looking sore, with hard and rising edges: the trade call it the soot-wart. I never saw it under the age of puberty”.


Mammary Cancer Lipid Emulsion Single Feeding Carcinogenic Polycyclic Aromatic Hydrocarbon Carcinogenic Hydrocarbon 
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  1. 1.
    Pott, P. Cancer scroti. The chirurgical works of Percivall Pott. London, Wood and Innes, 3: 174, 1808.Google Scholar
  2. 2.
    Yamagiwa, K., and Ichikawa, K. Experimentelle Studie über die Pathogenese der Epithelialgeschwülste. Mitt. Fak. K. Japan. Univ. Tokyo 15: 295, 1916.Google Scholar
  3. 3.
    Kennaway, E. L. The formation of a cancer-producing substance from Isoprene (2methyl-butadiene). J. Path. Bact. 27: 233, 1924.CrossRefGoogle Scholar
  4. 4.
    Cook, J. W., Hieger, I., Kennaway, E. L., and Mayneord, W. V. The production of cancer by pure hydrocarbons. Part I. Proc. Royal Soc. Lond. Ser. B 111: 455, 1932.CrossRefGoogle Scholar
  5. 5.
    Wieland, H., and Dane, E. Untersuchungen über die Konstitution der Gallensäuren. LII. Über die Haftstelle der Seitenketten. Z. Physiol. Chem. 219: 240, 1933.CrossRefGoogle Scholar
  6. 6.
    Bachmann, W. E., and Chemerda, J. M. The synthesis of 9,10-dimethyl-1,2-benzanthracene, 9,10-diethyl-1,2-benzanthracene and 5,9,10-trimethyl-1,2-benzanthracene. J. Am. Chem. Soc. 60: 1023, 1938.CrossRefGoogle Scholar
  7. 7.
    Huggins, C., and Yang, N. C. Induction and extinction of mammary cancer. Science 137: 257, 1962.PubMedCrossRefGoogle Scholar
  8. 8.
    Rees, E. D., and Huggins, C. Steroid influences on respiration, glycolysis and levels of pyridine nucleotide—linked dehydrogenases of experimental mammary cancers. Cancer Res. 20: 963, 1960.PubMedGoogle Scholar
  9. 9.
    Geyer, R. P. Parenteral nutrition. Physiol. Rev. 40: 150, 1960.PubMedGoogle Scholar
  10. 10.
    Schurr, P. E. Composition and preparation of experimental intravenous fat emulsions. Cancer Res. 29: 258, 1969.PubMedGoogle Scholar
  11. 11.
    Huggins, C. B., Ford, E., and Jensen, E. V. Carcinogenic aromatic hydrocarbons: Special vulnerability of rats. Science 147: 1153, 1965.PubMedCrossRefGoogle Scholar
  12. 12.
    Huggins, C., Grand, L., and Fukunishi, R. Aromatic influences on the yields of mammary cancers following administration of 7,12-dimethylbenz(a)anthracene. Proc. Natl. Acad. Sci. 51: 737, 1964.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Charles B. Huggins
    • 1
  1. 1.The Ben May Laboratory for Cancer ResearchUniversity of ChicagoChicagoUSA

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