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Technology of Induction of Cancer in Rat with Pulse-Doses of Homogenized Hydrocarbons

  • Charles B. Huggins

Abstract

The research began with the work of a thoughful and colorful surgeon, Percivall Pott (1713–1788), and his investigation(1) of cancer of the scrotum: “there is a disease as peculiar to a certain set of people, which has not, at least to my knowledge, been publicly noticed; I mean the chimney-sweeper’s cancer. It is a disease which always makes its first attack on, and its first appearance in, the inferior part of the scrotum; where it produces a superficial, painful, ragged, ill-looking sore, with hard and rising edges: the trade call it the soot-wart. I never saw it under the age of puberty”.

Keywords

Mammary Cancer Lipid Emulsion Single Feeding Carcinogenic Polycyclic Aromatic Hydrocarbon Carcinogenic Hydrocarbon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Pott, P. Cancer scroti. The chirurgical works of Percivall Pott. London, Wood and Innes, 3: 174, 1808.Google Scholar
  2. 2.
    Yamagiwa, K., and Ichikawa, K. Experimentelle Studie über die Pathogenese der Epithelialgeschwülste. Mitt. Fak. K. Japan. Univ. Tokyo 15: 295, 1916.Google Scholar
  3. 3.
    Kennaway, E. L. The formation of a cancer-producing substance from Isoprene (2methyl-butadiene). J. Path. Bact. 27: 233, 1924.CrossRefGoogle Scholar
  4. 4.
    Cook, J. W., Hieger, I., Kennaway, E. L., and Mayneord, W. V. The production of cancer by pure hydrocarbons. Part I. Proc. Royal Soc. Lond. Ser. B 111: 455, 1932.CrossRefGoogle Scholar
  5. 5.
    Wieland, H., and Dane, E. Untersuchungen über die Konstitution der Gallensäuren. LII. Über die Haftstelle der Seitenketten. Z. Physiol. Chem. 219: 240, 1933.CrossRefGoogle Scholar
  6. 6.
    Bachmann, W. E., and Chemerda, J. M. The synthesis of 9,10-dimethyl-1,2-benzanthracene, 9,10-diethyl-1,2-benzanthracene and 5,9,10-trimethyl-1,2-benzanthracene. J. Am. Chem. Soc. 60: 1023, 1938.CrossRefGoogle Scholar
  7. 7.
    Huggins, C., and Yang, N. C. Induction and extinction of mammary cancer. Science 137: 257, 1962.PubMedCrossRefGoogle Scholar
  8. 8.
    Rees, E. D., and Huggins, C. Steroid influences on respiration, glycolysis and levels of pyridine nucleotide—linked dehydrogenases of experimental mammary cancers. Cancer Res. 20: 963, 1960.PubMedGoogle Scholar
  9. 9.
    Geyer, R. P. Parenteral nutrition. Physiol. Rev. 40: 150, 1960.PubMedGoogle Scholar
  10. 10.
    Schurr, P. E. Composition and preparation of experimental intravenous fat emulsions. Cancer Res. 29: 258, 1969.PubMedGoogle Scholar
  11. 11.
    Huggins, C. B., Ford, E., and Jensen, E. V. Carcinogenic aromatic hydrocarbons: Special vulnerability of rats. Science 147: 1153, 1965.PubMedCrossRefGoogle Scholar
  12. 12.
    Huggins, C., Grand, L., and Fukunishi, R. Aromatic influences on the yields of mammary cancers following administration of 7,12-dimethylbenz(a)anthracene. Proc. Natl. Acad. Sci. 51: 737, 1964.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Charles B. Huggins
    • 1
  1. 1.The Ben May Laboratory for Cancer ResearchUniversity of ChicagoChicagoUSA

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