Transplantable Tumors as an Internal Stress on Host Metabolism and Responsiveness of Tumors to Applied Stress

  • Chung Wu
  • Jere M. Bauer


The growth of a malignant tumor within the body represents a type of metabolic stress for the host that is fundamentally different from that ordinarily encountered in adaptations made by the organism to a changing external environment. Although the tumor-host system is still dependent on the environment for its ultimate source of energy and essential nutrients, the malignant tumor and the host now must exist in a metabolic relationship, one with the other, since they share a common metabolic pool. Perhaps, the most gross, yet most valid, observation in cancer biology is that unrestrained growth of a malignant tumor will lead ultimately to death of the host. Although the precise cause of death from cancer is difficult to ascertain, the common observation of generalized wasting and loss of tissue substance seen in the host with advanced cancer is indicative of disrupted metabolic processes in the tissues of the host.


Glutamine Synthetase Glutamine Synthetase Activity Metabolic Modulation Host Liver Host Metabolism 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Chung Wu
    • 1
  • Jere M. Bauer
    • 1
  1. 1.Departments of Biological Chemistry and of Internal MedicineThe University of Michigan Medical SchoolAnn ArborUSA

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