The Response of Escherichia Coli to Fatty Acid Supplements and the Regulation of Membrane Lipid Synthesis

  • Salih J. Wakil
  • M. Esfahani


Despite many years of research, the exact nature of the molecular organization of the biological membrane is still a matter of much discussion and speculation. Several models have been proposed for membrane structure (Danielli and Dayson, 1935; Robertson, 1966; Benson, 1968; Green et al, 1967), each of which is based primarily on what is assumed for its function, and none of which has met a universal acceptability. However, what is generally agreed on is that the biomembrane consists of proteins, lipids, and water, and that lipid-protein interactions determine membrane function. A possible approach to the understanding of the structural requirements for the lipids and proteins which are essential for the expression of membrane function is alteration of these constituents and investigation into the effect of such alterations on membrane properties. To this purpose, alterations of the lipid component of the membrane have sounded promising (Silbert et al, 1968; McElhaney and Tourtellotte, 1969; Steim et al, 1969).


Fatty Acid Composition Unsaturated Fatty Acid Saturated Fatty Acid Elaidic Acid Fatty Acid Synthetase 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Salih J. Wakil
    • 1
  • M. Esfahani
    • 1
  1. 1.Biochemistry DepartmentDuke University Medical CenterDurhamUSA

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