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Narcotic Drugs pp 262-282 | Cite as

Corticosteroid Hormones

  • Jewell W. Sloan

Abstract

The effects of morphine and other narcotic analgesics on adrenal cortical secretion have been studied from three frames of reference: (1) The ability of chronic morphine administration to cause hypertrophy of the adrenal gland was first reported by McKay and McKay(1) and subsequently confirmed by other investigators.(2–5) Morphine was used by Selye(6) to first evoke an alarm reaction and its attendant increase in the adrenal cortical response. In addition to its ability to stimulate the adrenal cortex, Briggs and Munson(7) demonstrated that morphine in the anesthetized rat also could suppress the response to stressful stimuli. (2) Clinical observations and impressions indicated that morphine diminishes both sexual interest and excitability and that during the morphine abstinence syndrome spontaneous orgasms have been observed and reported.(8) (3) A relationship between the analgesic action of morphine and adrenal cortical function has been suggested by the observations that adrenalectomy reduces the analgesic action of morphine(9,10) and that steroids can both increase and decrease the analgesic action of morphine.(11,12) In this regard it is of interest that Craig(13) has reported on a steroid analgesic, 17-α-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxypregna-3,5-dien-20-one hydrochloride (SC-17599), that shares many of the pharmacological actions of morphine.

Keywords

Adrenal Cortex Narcotic Analgesic Abstinence Syndrome Steroid Excretion Chronic Morphine Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Jewell W. Sloan
    • 1
  1. 1.Addiction Research CenterLexingtonUSA

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