The Effects of Progesterone Administration on Hepatic Endoplasmic Reticulum: An Electron Microscopic and Biochemical Study
It is now well known that there are tiny membrane-limited channels ramifying throughout the cytoplasm of most cells. Porter (24) was the first to describe this lace-like reticulum of membranes with the electron microscope. Because of its association with the endoplasmic portion of the cell rather than the ectoplasm, it was referred to as the “endoplasmic reticulum” (25,26). In 1955, Fawcett (7) noted that two forms of the endoplasmic reticulum existed in the hepatic parenchymal cell. One form consisted of a system of membranes studded with ribosomes (rough-surfaced endoplasmic reticulum) and the other consisted of only a membranous network (smooth-surfaced endoplasmic reticulum).
KeywordsEndoplasmic Reticulum Microsomal Enzyme Smooth Endoplasmic Reticulum Male Hamster Hepatic Parenchymal Cell
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- 3.Conney, A.H., Schneidman, K., Jacobson, M., and Kuntzman, R. Drug induced changes in steroid metabolism. Am. N.Y. Acad. Sci. 123: (Art. 1) 98 (1965).Google Scholar
- 6.Fouts, J.R., Rogers, L.A., and Gram, T.E. The metabolism of drugs by hepatic microsomal enzymes. Studies on intramicroso- mal distribution of enzymes and relationships between enzyme activity and structure of the hepatic endoplasmic reticulum. Exp. Molec. Path. 5:475 (1966).PubMedCrossRefGoogle Scholar
- 8.Fawcett, D.W. Structural and functional variations in the membranes of the cytoplasm. In Intracellular Membraneous Structure, p. 15. Japan Society for Cell Biology, Okayama (1965).Google Scholar
- 9.Glaumann, H., and Dallner, G. Lipid composition and turnover of rough and smooth microsomal membranes in rat liver. J. Lipid Res. 1:720 (1968).Google Scholar
- 15.Jones, A.L., Ruderman, N.B., and Herrera, M.G. Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J. Lipid Research 8: 429 (1967).Google Scholar
- 16.Kadenback, B. Synthesis of mitochondrial proteins: demonstration of a transfer of proteins from microsomes into mitochondria. Biochem. Biophys. Acta 134:430 (1966).Google Scholar
- 17.Kuntzman, R., Lawrence, D., and Conney, A.H. Michaelis constants for the hydroxylation of steroid hormones and drugs by rat liver microsomes. Molec. Pharmacol. 1:163 (1965).Google Scholar
- 20.McKay, R., Druyan, R., and Rabinowity, M. Intramitochondrial loci for 6 aminoleuvulinic acid synthetase and ferrochelatase. Fed. Proceed. 27: 774 (1968).Google Scholar
- 28.Schimke, R.T., Ganschow, R., Doyle, D., and Arias, I.M. Regulation of protein turnover in mammalian tissues. Fed. Proceed. 27: 1223 (1968).Google Scholar
- 29.Shuster, L., and Jick, H. The turnover of microsomal protein in the livers of phenobarbital-treated mice. J. Biol. Chem. 241:5361 (1966).Google Scholar