Abstract
In attempting to evaluate effects of estrogens and progestational compounds on bone, it is important to consider how the components of the organic matrix may be affected. Bone consists of an inorganic mineral phase, which comprises approximately two thirds of the weight of the tissue, and an organic phase which is largely the protein collagen. Today I shall discuss selected studies on the effects of estrogens and progesterones on metabolism of collagen not only in bone but in other connective tissues as well. It is necessary, however, to review briefly some aspects of the chemistry and biology of collagen (1,2) in order to evaluate the results of such studies.
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References
Ramachandran, G.N. and Gould, B.S. (Eds.) A Treatise on Collagen. Academic Press, London and New York, 1968. Vol. 1, 2A and 2B.
Seifter, S. and Gallop, P.M.: The structure proteins, in The Proteins, H. Neurath (Ed.). Academic Press, New York, 1966, pp. 153–458.
Piez, K.A.: Cross-linking of collagen and elastin. Ann. Rev. Biochem. 37:547–570, 1968.
Gross, J.: Studies on the formation of collagen.II. The influence of growth rate on neutral salt extracts of guinea pig dermis. J. Exp. Med. 107:265–277, 1958.
Tanzer, M.L.: Experimental lathyrism. Int. Rev. Connective Tissue Res. 3:91–112, 1965.
Nimni, M.E. and Bavetta, L.A.: Collagen defect induced by penicillamine. Science 150:905–907, 1965.
Nimni, M.E.: A defect in the intramolecular and intermolecular cross-linking of collagen caused by penicillamine. I. Metabolic and functional abnormalities in soft tissues. J. Biol. Chem. 243: 1457–1466, 1968.
Harris, E.D., Jr. and Sjoerdsma, A.: Effect of penicillamine on human collagen and its possible application to treatment of scleroderma. Lancet 2:996–999, 1966.
Smith, Q.T. and Allison, D.J.: Changes of collagen content in skin, femur and uterus of 17 ß-estradiol benzoate-treated rats. Endocrinol. 79:486–492, 1966.
Kao, K.-Y.T., Hitt, W.E. and McGavack, T.H.: Connective tissue XIII. Effect of estradiol benzoate upon collagen synthesis by sponge biopsy connective tissue. Proc. Soc. Exp. Biol. Med. 119:364–367, 1965.
Henneman, D.H.: Effect of estrogen on in vivo and in vitro collagen biosynthesis and maturation in young and old female guinea pigs. Endocrinol. 83:678–690, 1968.
Young, M.M., Jasani, C., Smith, D.A. and Nordin, B.E.C.: Some effects of ethinyl oestradiol on calcium and phosphorus metabolism in osteoporosis. Clin. Sci. 34:411–417, 1968.
Katz, F.H. and Kappas, A.: The effect of natural estrogens on hydroxyproline excretion in man. J. Clin. Invest. 44: 1063, 1965.
Kühn, K., Stecher, K., Iwangoff, P., Hammerstein, F., Durruti, M., Holzmann, H. and Körting, G.W.: Studies on the metabolism of collagen III. The incorporation of (14C) glycine into the collagen of rats treated with progesterone. Biochem. Z. 343:528–536, 1965.
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© 1969 Plenum Press, New York
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Krane, S.M. (1969). Effects of Estrogens and Progesterones on Collagen Metabolism. In: Salhanick, H.A., Kipnis, D.M., Wiele, R.L.V. (eds) Metabolic Effects of Gonadal Hormones and Contraceptive Steroids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1782-1_40
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DOI: https://doi.org/10.1007/978-1-4684-1782-1_40
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