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Abstract

Although estrogens have been widely used in the treatment of postmenopausal osteoporosis for the last quarter century, surprisingly little is known of the effects of these hormones on adult skeletal metabolism. Furthermore, as has been usual in endocrine research, more is known of lower animals than of man. I will review the better known (and probably less relevant) skeletal effects of estrogens In birds, mice, and rats, will summarize what is known of estrogen effects in higher mammals and in menopausal women, will review with you our own results using calcium balance and calcium kinetic studies in women, and will conclude with a tentative effort at an explanation of estrogen effects on the adult skeleton.

Keywords

Estrogen Effect Ethinyl Estradiol Calcium Balance Skeletal Effect Estradiol Benzoate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. 1.
    McLean, F. C, and Urist, M. R.: Bone, Fundamentals of the physiology of skeletal tissue. 3rd Ed., pp. 119–124, U. Clin, Press, Chicago, III. (1968).Google Scholar
  2. 2.
    Budy, A. M., Urist, M. R, and McLean, F.C.: The effect of estrogens on the growth apparatus of the bones of immature rats. Am. J. Path. 28:1145–1167, (1952).Google Scholar
  3. 3.
    Gardner, W. U., and Pfeiffer, C. A.: Influence of estrogens and androgens on the skeletal system. Physiol. Rev., 23:139–165 (1943).Google Scholar
  4. 4.
    Wilkins, L.: The Diagnosis and Treatment of Endocrine Disorder in Childhood and Adolescence. 3rd Ed., Ed. R. M. Blizzard and C. J. Migeon, Charles C. Thomas, Springfield, III. (1965).Google Scholar
  5. 5.
    Garn, S. M., Rohmann, C. G. and Wagner, B.: Bone loss as a general phenomenon in man. Fed. Proc. 26:1729–1736 (1967).PubMedGoogle Scholar
  6. 6.
    Meema, H. E., Bunker, M. L. and Meema, S.: Loss of compact bone due to menopause. Obstet. Gynec. 26:333–343 (1965).PubMedGoogle Scholar
  7. 7.
    Wallach, S. and Henneman, P. H.: Prolonged estrogen therapy in postmenopausal women. JAMA 171:1637–1642 (1959)CrossRefGoogle Scholar
  8. 8.
    Davis, M. E., Strandjord, N. M. and Lanzl, L. H.: Estrogens and the aging process: The detection, prevention, and retardation of osteoporosis. JAMA 196:129–224 (1966).CrossRefGoogle Scholar
  9. 9.
    Young, M. M. and Nordin, B. E. C.: Effects of natural and artificial menopause on plasma and urinary calcium and phosphorus. Lancet 2:118–120 (1967).CrossRefGoogle Scholar
  10. 10.
    Nordin, B. E. C.: Hormones and Calcium Metabolism. In Calcified Tissues 1965. Proc. 3rd European Symp. on Calcified Tissues, Ed. H. Fleisch, H. J. J. Blackwood and M. Owen, Springer-Verlay, New York, Inc. 1966, pp, 226–241.Google Scholar
  11. 11.
    Nassim, J. R., Saville, P. D. and Mulligan, L.: The effect of stilbestrol on urinary phosphate excretion. Clin. Sci. 15:367 (1956).PubMedGoogle Scholar
  12. 12.
    Albright, F. and Reifenstein, E. C., Jr.: The parathyroid qlands and metabolic bone disease. Baltimore, 1948, Williams & Williams Co.Google Scholar
  13. 13.
    Plum, F. and Dunning, M. F.: Amelioration of hypercalciuria following poliomyelitis by l7-ethyl, 19-nortestosterone (Nilevar). J. Clin. Endocrinol. 18:860 (1958).CrossRefGoogle Scholar
  14. 14.
    Heaney, R. P.: Radiocalcium metabolism in disuse osteoporosis in man. Am. J. Med. 33:l88–200 (1962).CrossRefGoogle Scholar
  15. 15.
    Lafferty F. W., Spencer, G. E. and Pearson, O. H.: Effects of androgens, estrogens, and high calcium intakes on bone formation and resorption in orteoporosis. Am. J. 36:514–528 (1964).CrossRefGoogle Scholar
  16. 16.
    Schwartz, E., Panariello, V. A. and Saeli, J.: Radioactive calcium kinetics during high calcium Intake in osteoporosis. J. Clin. Invest. 44:1547–1560 (1965).PubMedCrossRefGoogle Scholar
  17. 17.
    Jowsey, J.: Age changes In human bone. Clin. Orthopaed. 17:210 (1960).Google Scholar
  18. 18.
    Frost, H. M.: Bone remodelling dynamics. Charles C. Thomas, Springfield, III. (1963).Google Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • Robert P. Heaney
    • 1
  1. 1.Creighton University School of MedicineOmahaUSA

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