Effects of Gonadal Hormones and Contraceptive Steroids on Respiration

  • M. Stein
  • A. Tarabeih
  • T. Yasutake
  • T. Hirose

Abstract

When the editors assigned me the task of reviewing the effects of gonadal hormones and contraceptive steroids on the pulmonary system, I replied that I was in somewhat of a quandry as to where to begin. Their suggestion was merely that all biological literature be reviewed and any appropriate data pertaining to these steroids and respiration be presented. Thus, my first reference was found in Genesis (1) and describes a most dramatic effect of estrogens on a portion of the pulmonary system of man (Fig. 1). Thus far, no one has been able to reproduce that experiment.

Keywords

Obesity Estrogen Respiration Serotonin Testosterone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Genesis: 2: 21Google Scholar
  2. 2.
    Hasselbalch, K.A., and Gammeltoft, S.A.: Die Neutral- itaetregulation des graviden Organisms. Biochem. Ztchr. 68: 206 (1915).Google Scholar
  3. 3.
    Heerharber, I., Loeschcke, H.H., and Westphal, U.: Eine Wirkung des Progesterons auf die Atmung. Arch. f. d. ges. Physiol. 250:42–55 (1948).CrossRefGoogle Scholar
  4. 4.
    Bokelmiann, O., u. I. Rother: Z. Geburtsh. Gynak. 584 (1924).Google Scholar
  5. 5.
    Wilbrand, U., Porath, C.H., Matthies, P., and Jaster, R.: Der Einfluss der Ovarialsteroid auf die Funktion des Atemzentrum. Arch, fur gynkologie. 191:507–531 (1959).CrossRefGoogle Scholar
  6. 6.
    Tyler, J.M.: The effect of progesterone on the respiration of patients with emphysema and hypercarbia. J. Clin. Invest. 39:34–41 (1960).PubMedCrossRefGoogle Scholar
  7. 7.
    Lyons, H.A., and Huang, C.T.: Therapeutic use of progesterone in alveolar hypoventilation associated with obesity. I Am. J. Med. 44. 881–888 (1968).PubMedCrossRefGoogle Scholar
  8. 8.
    Lyons, H.A.: Ventilatory responses to progesterone, (this volume)Google Scholar
  9. 9.
    Cugell, W.D., Frank, N.R., Gaensler, E.A., and Badger, T.L.: Pulmonary function in pregnancy. Am. Rev. Tuberc. 67: 568–597 (1953).PubMedGoogle Scholar
  10. 10.
    Novy, M.J., and Edwards, M.J.: Respiratory problems in pregnancy. Am. J. Obs. Gyn. 99:1024–1045 (1967).Google Scholar
  11. 11.
    Rubin, A.M.D., Russo, N., and Gaucher, D.: The effect of pregnancy on pulmonary functions in normal women. Am. J. Obs. and Gyn. 72:963–969 (1956).Google Scholar
  12. 12.
    Gee, J.B.L., Packer, B.S., Miller, J.E. and Robin, E.D.: I Pulmonary mechanics during pregnancy. J. Clin. Invest. 16:945–952 (1967).CrossRefGoogle Scholar
  13. 13.
    Winter, L.W., and Sullivan, K.N.: The role of the diaphragm and hormones in changing pulmonary functions during pregnancy. Clin. Res. 16:474 (1964).Google Scholar
  14. 14.
    Trethewie, E.R., and Gaffney, F.M.: Influence of gonado- trophic hormones on the histamine content of and ease of release of histamine by trypsin from guinea pig lung. Austral. J. Exp. Biol, and M. Sci. 27:867–868 (1949).Google Scholar
  15. 15.
    Wessler, S., Freiman, D.G., Ballon, J.D., Katz, J.H., Wolff, R., and Wolf, E.: Experimental pulmonary embolism with serum-induced thrombi. Am. J. Pathol. 38:89–100 (1961).PubMedGoogle Scholar
  16. 16.
    Wessler, S. and Thye Yin, E.: Hypercoagulability, (this volume).Google Scholar
  17. 17.
    Stein, M. and Thomas, D.P.: Role of platelets in the acute pulmonary responses to endotoxin. J. Appl. Physiol. 23: 47–51 (1967).PubMedGoogle Scholar
  18. 18.
    Thomas, D.P., Gurewich, V., and Ashford, T.P.: Platelet adherence to thromboemboli in relation to the pathogenesis and treatment of pulmonary embolism. New Eng. J. Med. 274:953–956 (1966).Google Scholar
  19. 19.
    Stein, M., Hlrose, T., Yasutake, T., and Khan, M.A.:; The effects of platelet amines on airway fimction. in Conference on Airway Dynamics, A. Bouhuys, editor, Charles C. Thomas, Chicago, Illinois, In Press.Google Scholar
  20. 20.
    Horan, J.D. and Ledeman, J.J.: Possible asthmogenic effect of oral contraceptives. Correspondence. Canad. Med. Ass. J.99: 130–131 (1968).PubMedGoogle Scholar
  21. 21.
    Hears, E.: Letter to the editor. Lancet i:981 (1964).Google Scholar
  22. 22.
    Chen, C.Y.: Clinical studies in bronchial asthma. The influence of the gonadal hormones on asthma in the female. J. Formosa Med. Ass.61: 766–773 (1962).PubMedGoogle Scholar
  23. 23.
    Ogilvie, C.M., Forster, R.E., Blakemore, W.S., and Morton, J.W.: A standardized breath holding technique for the f clinical measurement of the diffusing capacity of the lung for f carbon monoxide. J. Clin. Invest. 36:1–17 (1957).PubMedCrossRefGoogle Scholar
  24. 24.
    Pecora, L.J., Putnam, L.R., and Baum, G.L.: Effects of intravenous estrogens on pulmonary diffusing capacity. Am. J. Med. Sci. 48–52 (1963).Google Scholar
  25. 25.
    Wayne, L., Coots, M., Glueck, H.I., Baum, G., Pecora, L., and Putnam, L.: The effect of intravenous estrogen on tissues and capillaries as measured by coagulation tests, intradermal hyaluronidase, hyaluronidase serum inhibitor and pulmonary diffusion studies. J. Lab. and Clin. Invest. 58:970 (1961).Google Scholar
  26. 26.
    Schiff, M. and Bum, H.F.: The effect of intravenous: estrogen on ground substance. Arch. Otolaryng. 73:43–51 (1961).PubMedCrossRefGoogle Scholar
  27. 27.
    El-Heneidy, A.R., Helmy, I.D., and Michael, M.A.: Experimental diffuse interstitial fibrosis of the lungs and capillary cellular trapping. Alex. Med. J. 12:275–307 (1966).Google Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • M. Stein
    • 1
    • 2
  • A. Tarabeih
    • 1
    • 2
  • T. Yasutake
    • 1
    • 2
  • T. Hirose
    • 1
    • 2
  1. 1.Department of Biology and Medical SciencesBrown UniversityProvidenceUSA
  2. 2.The Department of MedicineRhode Island HospitalProvidenceUSA

Personalised recommendations