Influence of Long-Lasting Asbestos Exposure on Immunological Status of Asbestos Exposed Shipyard Workers

Abstract

Investigation into the fibrogenic and possibly carcinogenic effects of asbestos fibres have been centred largely on the structural and aerodynamic properties of the fibres (Timbrell, 1973). However, other factors, particularly the body’s defences and altered immune competence, have also been linked with asbestos exposure. Epidemiological and immunological studies of asbestos workers have documented abnormalities in both humoral and cell-mediated immunity (Doll et al., 1983). Immune response to asbestos has been suggested as an important component in the pathophysiology of asbestosis (Pernis & Vigliani, 1982), however, the effect of asbestos inhalation on local or systemic immunity is not well understood. The majority of workers developing asbestosis have been exposed to high dust concentrations for a prolonged periods of time. There are, however, many workers who remain healthy in spite of the significant exposure to asbestos (Turner-Warwick, 1973). The aim of this study was to compare the immunological alterations that occur in an asbestos-exposed diseased group and in an asbestos-exposed non-diseased group.