Mechanisms of Fibre Genotoxicity

  • Marie-Claude Jaurand
Part of the NATO ASI Series book series (NSSA, volume 223)


Neoplastic transformation is a multistep process involving the arrangement, amplification, mutation or deletion of specific genes. Several mechanisms may account for these gene modifications; they include point mutations and chromosome mutations (see Barrett, this volume). Genotoxic agents may be responsible for primary or secondary events which play a critical role in cell transformation by the production, not only of point mutations, but also of heritable changes through gene modifications and rearrangements. Agents that interact with DNA structure, chromosomes or even interfere with DNA metabolism are potentially genotoxic.


Mesothelial Cell Sister Chromatid Exchange Asbestos Exposure Asbestos Fiber Tracheal Epithelial Cell 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Marie-Claude Jaurand
    • 1
  1. 1.Laboratory of Cellular and Molecular ToxicologyCHU Henri MondorCreteil CedexFrance

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