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Acute Pulmonary Effects of Inhaled Wollastonite Fibers are Dependent on Fiber Dimensions and Aerosol Concentrations

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Mechanisms in Fibre Carcinogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 223))

Abstract

Occupational exposure to asbestos fibers has been associated with the development of pulmonary fibrosis (i.e., asbestosis), bronchogenic carcinoma and mesothelioma. Therefore, the commercial use of asbestos is likely to be curtailed or limited in the near future and mineral fiber substitutes are currently being promoted to fill the void. Wollastonite fibers are natural acicular calcium silicate minerals which have been proposed as alternatives for asbestos in applications such as brake linings, wallboard and insulation materials. Wollastonite fiber diameters are generally in the 1–10 µm range with an average diameter of 3.5 µm (Vu, 1988).

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References

  • Adkins,B. Jr., McConnell,E.E. and Hall,L. (1989) Carcinogenicity studies of wollastonite in rats. Toxicologist 9: 212A.

    Google Scholar 

  • Bolton,R.E., Addison,J., Davis,J.M.G., Donaldson,K., Jones,A.D., Miller,B.G. and Wright,A. (1986) Effects of the inhalation of dusts from calcium silicate insulation materials in laboratory rats. Enivron. Res. 39: 26–43.

    Article  CAS  Google Scholar 

  • Bowden,D.H. and Adamson,I.Y.R. (1984) The role of cell injury and the continuing inflammatory response in the generation of silicotic pulmonary fibrosis. J. Pathol. 144: 149–161.

    Article  PubMed  CAS  Google Scholar 

  • Dauber,J.H., Rossman,M.D. and Daniele,R.P. (1982) Pulmonary fibrosis: Bronchoalveolar cell types and impaired function of alveolar macrophages in experimental silicosis. Environ. Res. 27: 226–236.

    Article  PubMed  CAS  Google Scholar 

  • Hill,L.H. and Plopper,C.G. (1979) Use of large block embedding for correlated LM, TEM and SEM characterization of pulmonary airways at known anatomic location. Proc. Southeast Elect. Microsc. Soc. 1: 24.

    Google Scholar 

  • Lugano,E.M., Dauber,J.H. and Daniele,R.P. (1982) Acute experimental silicosis. Lung morphology, histology, and macrophage chemotaxin secretion. Am. J. Pathol. 109: 27–36.

    PubMed  CAS  Google Scholar 

  • Reiser,K.M. and Last,J.A. (1986) Early cellular events in pulmonary fibrosis. Exp. Lung Res. 10: 331–355.

    Article  PubMed  CAS  Google Scholar 

  • Vu,V.T. (1988) Health Hazard Assessment of Non-asbestos Fibers. USEPA report.

    Google Scholar 

  • Warheit,D.B., Hill,L.H. and Brody,A.R. (1983) Pulmonary macrophage phagocytosis: quantification by secondary and backscattered electron imaging. Scan. Electron Microsc. 1: 431–437.

    Google Scholar 

  • Warheit,D.B., Hill,L.H. and Brody,A.R. (1984a) Surface morphology and correlated phagocytic capacity of pulmonary macrophages lavaged from the lungs of rats. Exp. Lung Res. 6: 7182.

    Article  Google Scholar 

  • Warheit,D.B., Chang,L.Y., Hill,L.H., Hook,G.E.R., Crapo,J.D. and Brody,A.R. (1984b) Pulmonary macrophage accumulation and asbestos-induced lesions at sites of fiber deposition. Am. Rev. Respir. Dis. 129: 301–310.

    PubMed  CAS  Google Scholar 

  • Warheit,D.B., Hill,L.H. and Brody,A.R. (1984c) In vitro effects of crocidolite asbestos and wollastonite on pulmonary macrophages and serum complement. Scan. Electron Microsc. 11: 919–926.

    Google Scholar 

  • Warheit,D.B., Overby,L.H., George,G. and Brody,A.R. (1988) Pulmonary macrophages are attracted to inhaled particles through complement activation. Exp. Lung Res. 14: 51–66.

    Article  PubMed  CAS  Google Scholar 

  • Warheit,D.B., Carakostas,M.C., Hartsky,M.A. and Hansen,J.F. (1991a) Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: Comparisons of pulmonary responses to carbonyl iron and silica. Toxicol. Appl. Pharmacol. 107: 350–368.

    Article  PubMed  CAS  Google Scholar 

  • Warheit,D.B., Hwang,H.C. and Achinko,L. (1991b) Assessments of lung digestion methods for recovery of fibers. Environ. Res., in press.

    Google Scholar 

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© 1991 Plenum Press, New York

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Warheit, D.B., Moore, K.A., Carakostas, M.C., Hartsky, M.A. (1991). Acute Pulmonary Effects of Inhaled Wollastonite Fibers are Dependent on Fiber Dimensions and Aerosol Concentrations. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_15

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  • DOI: https://doi.org/10.1007/978-1-4684-1363-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1365-6

  • Online ISBN: 978-1-4684-1363-2

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