Studies on Plant Tissue Culture — Synthesis and Biosynthesis of Biologically Active Substances
The plant kingdom has provided literally thousands of natural products with widely diverse chemical structures and a vast array of biological activities many of which have seen subsequent application in the pharmaceutical, agrochemical and related industries. Extensive efforts have been expended toward structure elucidation of such compounds and subsequent laboratory syntheses. Due to their structural complexity, these compounds are generally amenable only through multistep syntheses and/or direct isolation from the living plant. Both processes are often fraught with difficulties. Multi-step syntheses although providing obvious challenges in development of synthetic strategies and training for young synthetic chemists, are rarely useful in any practical production of such natural products often required in large scale for their use as drugs, etc. In a similar manner, isolation of the target compounds by extraction from the plant can be associated with various problems (Figure 1).
KeywordsFermentation Immobilization MeOH NADH Alkaloid
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