Studies on Plant Tissue Culture — Synthesis and Biosynthesis of Biologically Active Substances

  • James P. Kutney
Part of the NATO ASI Series book series (NSSA, volume 207)

Abstract

The plant kingdom has provided literally thousands of natural products with widely diverse chemical structures and a vast array of biological activities many of which have seen subsequent application in the pharmaceutical, agrochemical and related industries. Extensive efforts have been expended toward structure elucidation of such compounds and subsequent laboratory syntheses. Due to their structural complexity, these compounds are generally amenable only through multistep syntheses and/or direct isolation from the living plant. Both processes are often fraught with difficulties. Multi-step syntheses although providing obvious challenges in development of synthetic strategies and training for young synthetic chemists, are rarely useful in any practical production of such natural products often required in large scale for their use as drugs, etc. In a similar manner, isolation of the target compounds by extraction from the plant can be associated with various problems (Figure 1).

Keywords

Fermentation Immobilization MeOH NADH Alkaloid 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J. P. Kutney, Nat. Prod. Rep., 7:85 (1990), and references cited therein.CrossRefGoogle Scholar
  2. 2.
    J. P. Kutney, Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed., Interscience, Amsterdam, Vol. 2, Structure Elucidation (Part A), (1988), p. 365, and references cited therein.Google Scholar
  3. 3.
    J. P. Kutney, Heterocycles, 25:617 (1987).CrossRefGoogle Scholar
  4. 4.
    J. P. Kutney, T. Hibino, E. Jahngen, T. Okutani, A. Ratcliffe, A. M. Treasurywala, S. Wunderly, Helv. Chim. Acta. 59:2858 (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    N. Langlois, F. Gueritte, Y. Langlois, P. Potier, J. Am. Chem. Soc., 98:7017 (1976).PubMedCrossRefGoogle Scholar
  6. 6.
    J. P. Kutney, C. A. Boulet, L. S. L. Choi, W. Gustowski, M. McHugh, J. Nakano, T. Nikaido, H. Tsukamoto, G. M. Hewitt, R. Suen, Heterocycles, 27:621 (1988).CrossRefGoogle Scholar
  7. 7.
    J. P. Kutney, L. S. L. Choi, J. Nakano, H. Tsukamoto, Heterocycles, 27:1827 (1988).CrossRefGoogle Scholar
  8. 8.
    J. P. Kutney, L. S. L. Choi, J. Nakano, H. Tsukamoto, M. McHugh, C. A. Boulet, Heterocycles, 27:1845 (1988).CrossRefGoogle Scholar
  9. 9.
    I. Jardine, Anticancer Agents Based on Natural Product Models; J. M. Cassady, J. D. Douros, Eds., Academic Press, New York (1980), p. 319, and references cited therein.Google Scholar
  10. 10.
    S. Huang, The Saint Peasant’s Scripture of Materia Medica; Publishing House for Chinese Medical Classics, Beijing, republ. (1982), p. 309.Google Scholar
  11. 11.
    D. Y. J. Yu, Traditional Chinese Med., 3:125 (1983).Google Scholar
  12. 12.
    J. Guo, S. Yuan, X. Wang, S. Xu, D. Li, Chinese Med. J., 7:405 (1981).Google Scholar
  13. 13.
    W. Xu, J. Zheng, X. Lu, Intl. J. Dermatol., 24:152 (1985).Google Scholar
  14. 14.
    S. M. Kupchan, W. A. Court, R. G. Dailey, C. J. Gilmore, R. F. Bryan, J. Am. Chem. Soc.. 94:7194 (1972).PubMedCrossRefGoogle Scholar
  15. 15.
    J. P. Kutney, M. H. Beale, P. J. Salisbury, R. D. Sindelar, K. L. Stuart, B. R. Worth, P. M. Townsley, W. T. Chalmers, D. J. Donnelly, K. Nilsson, G. G. Jacoli, Heterocycles. 14:1465 (1980).CrossRefGoogle Scholar
  16. 16.
    J. P. Kutney, G. M. Hewitt, T. Kurihara, P. J. Salisbury, R. D. Sindelar, K. L. Stuart, P. M. Townsley, W. T. Chalmers, G. G. Jacoli, Can. J. Chem.. 59:2677 (1981).CrossRefGoogle Scholar
  17. 17.
    J. P. Kutney, L. S. L. Choi, R. Duffin, G. Hewitt, N. Kawamura, T. Kurihara, P. Salisbury, R. Sindelar, K. L. Stuart, P. M. Townsley, W. T. Chalmers, F. Webster, G. G. Jacoli, Planta Med., 48:158 (1983).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • James P. Kutney
    • 1
  1. 1.Department of ChemistryUniversity of British ColumbiaVancouverCanada

Personalised recommendations