Synthesis of Homochiral Pharmaceuticals using Effective Enantioselective Biocatalysts

  • H. J. Kooreman
  • J. H. G. M Mutsaers
Part of the NATO ASI Series book series (NSSA, volume 207)

Abstract

Scientists, both in academia and industry, as well as regulatory authorities become more and more aware of the importance of enantioselectivity in drug innovation. About 25% of the medicines used to-day are racemic mixtures. The therapeutic activity nearly always resides in one of the isomers (the so-called eutomer), while the other isomer (distomer) can have an unwanted interaction with the human body; at best the distomer is a metabolic burden. Essentially the same holds true for other interactions between synthetic organic compounds and biological systems e.g. the impact of agrochemicals on ecosystems.

Keywords

Lipase Lysine Bacillus Ibuprofen Metoprolol 

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • H. J. Kooreman
    • 1
  • J. H. G. M Mutsaers
    • 2
  1. 1.International Bio-Synthetics B.VRijswijkThe Netherlands
  2. 2.Gist-brocades nv R&D DepartmentDelftThe Netherlands

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