Abstract
The Mex-(or Mer-) (Sklar and Strauss, 1981; Day, et al., 1980) phenotype of human cells results in a sensitivity to certain alkylating agents. Foremost among the compounds to which Mex- cells are sensitive are the alkylnitrosamines and alkylnitrosamides which can form covalent adducts with cellular DNA at the O6-position of guanine. A particularly important class of such compounds is the cross-linking nitrosoureas which are widely used in chemotherapy. The molecular basis of the Mex- phenotype is not fully characterised, although it appears to be associated with the transformed state in as far as normal human cells are Mex+ but may become Mex- following transformation in vitro. Thus, the phenotype is important from the practical viewpoint of chemotherapy, as well as a more fundamental one of understanding the events which occur during cellular transformation.
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© 1989 Plenum Press, New York
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Karran, P. et al. (1989). The Molecular Basis of Alkylating Agent Resistance in Mammalian Cells. In: Lambert, M.W., Laval, J. (eds) DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells. NATO ASI Series, vol 182. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1327-4_9
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DOI: https://doi.org/10.1007/978-1-4684-1327-4_9
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