Towards a Role for Promutagenic Lesions in Carcinogenesis
The reactions of alkylating agents with DNA are now widely considered to be major determinants in the toxic, mutagenic, carcinogenic and other biological properties of these compounds. Until recently, it has not been possible to begin to confirm the relevance of such observations for human disease, but techniques now permit preliminary studies of these potentially initiating events in human tissues.
KeywordsPositive Nucleus Target Cell Population Uninvolved Tissue Sister Chromatid Exchange Induction Repair Deficient Cell
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