Towards a Role for Promutagenic Lesions in Carcinogenesis

  • Peter J. O’Connor
Part of the NATO ASI Series book series (NSSA, volume 182)

Abstract

The reactions of alkylating agents with DNA are now widely considered to be major determinants in the toxic, mutagenic, carcinogenic and other biological properties of these compounds. Until recently, it has not been possible to begin to confirm the relevance of such observations for human disease, but techniques now permit preliminary studies of these potentially initiating events in human tissues.

Keywords

Radium Pyrene Adenine Triad Guanine 

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Peter J. O’Connor
    • 1
  1. 1.CRC Section of Carcinogenesis, Paterson Institute for Cancer ResearchChristie Hospital and Holt Radium InstituteManchesterUK

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